Objective To investigate the relationship between serum lipoprotein associated phospholipase A2(Lp-PLA2) levels and severity of coronary artery disease in patients with stable coronary artery disease (SCAD). Methods 480 cases of patients with coronary heart disease (CHD) diagnosed by coronary angiography (CAG) were enrolled in the study. Among them, there were 218 patients with SCAD (SCAD group) and 262 patients with acute coronary syndrome (ACS) (ACS group).186 cases of patients without history of heart disease or suspected heart disease and without CHD diagnosed by CAG were selected as the non-CHD group. The serum Lp-PLA2 levels were determined by turbidimetric inhibition immuno assay. Results Lp-PLA2 levels and Gensini score in ACS group were higher than those in SCAD group and non-CHD group, and those in SCAD group were higher than non-CHD group. Lp-PLA2 levels in patients with three-vessel coronary artery disease in SCAD group were higher than those in patients with single or double-vessel coronary artery disease, and the levels were higher in patients with double-vessel coronary artery disease than patients with single-vessel coronary artery disease. Lp-PLA2 levels in patients with Gensini score ≥40 points were higher than those in patients with Gensini score < 20 points and Gensini score of 20~39 points, and the levels were higher in patients with Gensini score of 20~39 points than patients with Gensini score < 20 points. Lp-PLA2 levels in patients with unstable plaques in SCAD group were higher than those in patients without plaques and patients with stable plaques, and the levels were higher in patients with stable plaques than those without plaques. Pearson correlation analysis showed that Lp-PLA2 level was positively correlated with the number of lesions and Gensini score. Conclusion The serum Lp-PLA2 level in patients with SCAD is higher than that in patients without CHD. The level is positively correlated with the severity of coronary artery disease, and can reflect the instability of plaque.

 Objective To study the application effect spinal-epidural combined with anesthesia in the treatment of pregnancy-induced hypertension in cesarean section. Methods 88 patients with pregnancy-induced hypertension from March 2013 to February 2016 were selected in our hospital, those patients were randomly divided into observation group and control group according to random number, 44 cases in each group. Continuous epidural anesthesia were used in the control group, the observation group were taken spinal-epidural combined with anesthesia. The anesthetic effect, hemodynamics, neonatal Apgar score and fetal delivery time were compared between the two groups. Results The total anesthetic volume, anesthesia onset time and pain level in the observation group were significantly lower than the control group ［ (1.87±0.23) mL, (10.43±1.23) min, (11.48±1.76) min VS (15.32±2.41) mL, (15.76±1.56) min, (15.34±1.21) min］. The muscle relaxation effect of the observation group was significantly better than the control group. The systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate in the observation group were significantly lower than those in the control group ［ (118.45±12.32) mmHg, (73.48±7.02) mmHg, (74.53±7.21) time / min VS (130.98±13.21) mmHg, (82.98±10.43) mmHg, (82.79±8.37) times / min］. There was no significant difference in Apgar scores between the two groups. The time of delivery of the fetus in the observation group was significantly shorter than the control group ［ (22.54±2.34) min vs (38.87±4.57) min］. Conclusion Spinal-epidural combined with anesthesia can reduce the pain of cesarean section in pregnancy - induced hypertension syndrome, stabilize the hemodynamics index of maternal and ensure the safety of mother and fetus. The anesthesia effect is good.

Objective To investigate the effects of cisatracurium on Muscle relaxation and postoperative recovery in patients undergoing inhalation anesthesia and intravenous anesthesia. Methods 84 cases of patients with under general anesthesia were collected adn randomly divided into Sevoflurane inhalation anesthesia group (Inhalation anesthesia group) and Propofol-remifentanil group (intravenous anesthesia group), The cisatracurium infusion rate, recovery index and postoperative recovery were recorded. Results With the maintenance of a neuromuscular blockade, the infusion rate was significantly lower in sevoflurane group than in propofol-remifentanil group, In the inhaled anesthesia group, the time of eye opening and the time of shaking call was shorter than that of intravenous anesthesia. The incidence of delayed awakening in the inhaled anesthesia group was lower than that in the intravenous anesthesia group (2.38% / 7.14%), (11.90% / 2.38%), the difference was statistically significant. Conclusion Inhalation anesthesia with propofol-propofol-remifentanyl total intravenous anesthesia can be time-dependent enhancement of cisatracurium-induced muscle relaxation effect, and the former is better than the latter, while inhalation anesthesia is more conducive to patients Wake, reduce agitation, But prone to restlessness, the clinical application of patients under a reasonable choice.

Objective To study the efficacy of laparoscopic common bile duct exploration without T-tube suture in the treatment of common bile duct stones. Methods 408 cases of patients with common bile duct stones who were hospitalized from February 2012 to June 2016 were selected as the subjects. All the patients were randomized to the control group and the observation group, each group of 204 cases. The control group received laparoscopic common bile duct exploration (with T-tube suture); and the patients in the observation group were treated with laparoscopic common bile duct exploration without T-tube suture. The operative parameters, postoperative recovery effect and postoperative complications were observed. Results The operative time and intraoperative blood loss were significantly lower in the observation group than in the control group. The primary exhaust time, drainage time and hospital stay were lower in the observation group than those in the control group, the difference was statistically significant. There was no significant difference between the two groups in the bile duct hemorrhage, infection, stenosis and bile leakage. Conclusion In the treatment of common bile duct stones, laparoscopic common bile duct exploration without T-tube suture treatment of surgical trauma, bleeding less, can reduce the risk of postoperative complications, conducive to postoperative recovery as soon as possible, shorten the hospital Time, more with a minimally invasive surgical advantage.

Objective To study the diagnostic value of miniprobe endoscopic ultrasonography in the diagnosis of colorectal precancerous lesions, and provide reference for clinical prevention and treatment. Methods From January 2016 to May 2017 received 85 cases of colorectal polypoid lesions in patients with colonoscopy examination in our hospital as the research object, and were confirmed by pathological diagnosis, there were 157 polyps like lesions. All patients underwent micro probe endoscopic ultrasonography, the pathological diagnosis as the gold standard were analyzed. Results 157 polypoid lesions, 62 hyperplastic / inflammatory polyp, 81 adenoma, 14 of adenocarcinoma; NBI lesions The contour and surface structure, microvascular morphology definition was significantly better than that of ordinary endoscopy, the difference was statistically significant; NICE typing showed that 157 lesions: 61 lesions were type I, 80 lesions were type Ⅱ, 16 lesions were type Ⅲ; sensitivity and specificity of micro probe endoscopic ultrasonography check the large bowel tumor lesions, the accuracy was 94.7%, 90.3%, 93%; stage compared with the postoperative pathological diagnosis, micro probe endoscopic ultrasonography in diagnosis of colon cancer T staging accuracy rate of diagnosis is 85.7%. Conclusion Miniprobe endoscopic ultrasonography in the diagnosis of colorectal precancerous lesions. High value, can effectively improve the detection rate of colorectal precancerous lesions, with high sensitivity and specificity, accuracy, worthy of promotion.

Objective To investigate the changes of cystatin C (CysC), hypersensitive C reactive protein (hs-CRP) and homocysteine (Hcy) levels in patients with pregnancy induced hypertension and their diagnostic value. Methods Choose 5 years, 2017 to July 2015 in our hospital treated 120 cases of patients with pregnancy-induced hypertension disease as the observation group, and at the same time choose in our hospital treated 150 cases of normal pregnancy pregnant women as control group. Compare two groups of patients with CysC, hs CRP and Hcy levels and pregnancy outcomes, and Logistic regression analysis. Results The CysC, hs - CRP and Hcy levels of observation group patientsr espectively were (1.68±0.41) mg/L、 (14.58±0.59) mg/L、 (20.65±1.12)μmol/L, the patients were significantly higher than the level of the control group (0.85±0.35) mg/L、 (3.43±0.37) mg/L、 (8.27±0.98)μmol/L, the difference between groups was statistically significant. Patients with severe pregnancy-induced hypertension CysC, hs - CRP and Hcy levels higher than that of patients with mild, moderate, mild gestational hypertension CysC, hs - CRP and Hcy levels higher than that of patients with mild, the comparison group difference was statistically significant. Observation group of patients with premature delivery, fetal distress and the perinatal death accounted for 20.00%, 29.17% and 29.17%, respectively, significantly higher than that of control group patients were 5.33%, 5.33%, 10.00%, diff between groups was statistically significant. Logistic regression analysis, gestational hypertension disease as the dependent variable, independent variable for CysC, hs - CRP and Hcy, the results show that CysC, hs - CRP and Hcy is associated with gestational hypertension disease difference was statistically significant. Conclusion He levels of CysC, hs-CRP and Hcy in patients with pregnancy induced hypertension are increasing with the aggravation of the disease. It is a sensitive index of the disease, and has important clinical diagnostic value.

Objective To investigate the clinical effect of automatic eustachian tube blow + balloon dilatation in the treatment of secretory otitis media in patients with nasopharyngeal carcinoma radiotherapy. Methods 80 patients with nasopharyngeal carcinoma treated with secretory otitis media were enrolled from January 2014 to April 2016. According to the random number table method, the selected subjects were randomly divided into control group (42 cases) and observation group (38 cases). The patients in the control group were treated with tympanostomy. The patients in the observation group were treated with automatic eustachian tube bleed and balloon dilatation. The clinical efficacy of the two groups after 6 months of treatment, the 3-month, 6-month, 12-month Eustachian tube dysfunction score and the Valsalva test score, and the incidence of adverse events were observed. Results The clinical effective rate (94.74%) in the observation group was significantly higher than that in the control group (76.19%), the difference was statistically significant; Two groups of patients after 3 months, 6 months, 12 months were significantly lower than before treatment, the patients in the observation group had the same time ETQR-7 score were significantly lower than those in the control group; The Valsalva score was decreasing in the two groups at 3 months, 6 months, and 12 months, and the observation group was followed by the Valsalva score was significantly lower than that in the control group. The incidence of recurrence and the recurrence rate (7.89%) in the observation group were lower than those in the control group (42.86%), which was statistically significant. Conclusion The treatment of secretory otitis media in patients with nasopharyngeal carcinoma radiotherapy has significant clinical effect, which can effectively improve the Eustachian tube dysfunction and clinical symptoms, low recurrence rate, high safety and wide In clinical application.

Objective To study the curative effect of different regimens on diabetic peripheral neuropathy (DPN). Methods 96 cases ofpatients with DPN treated in our hospital fromOctober 2015 to February 2017 were selected as study subjects, andthey were divided into A, B and C three groups by random number table method, with 32 cases in each group. Group A were treated with mecobalamin on the basis of routine treatment. Based on the treatment for group A, group B were additionally treated with αlipoic acid, and group D were additionally treated with Mudan granules and α lipoic acid. The blood glucose, blood lipids, vibration sense, pressure sense, temperature sense, ankle jerk, symptom score and adverse reactions were compared among the three groups before treatment and after 10 days of treatment. Results After 10daysof treatment, the vibration perceptionthresholds (VPT) of left and right lower limbs of group C ［ (15.24±2.95) V, (15.07±2.75) V］ were significantly lower than those of group A and group B, while VPT of left and right lower limbs of group B ［ (17.39±3.63) V, (17.11±3.21) V］ were significantly lower than those of group A ［ (19.62±3.14) V, (19.35±2.87) V］. The abnormal rates of ankle jerkin group B and group C after 10 days of treatment (18.8% and 15.6%) were significantly lower than that in group A (43.8%). Conclusion Mudan granules combined with α lipoic acid and mecobalamin can promote the repair of damaged nerve tissues andrelieve symptoms of DPN.

 Objective To investigate the effect of Bacillus Licheniformis Capsule on dysbiosis of intestinal flora caused by GP chemotherapy for inoperable non-small cell lung cancer (NSCLC). Methods 98 cases of patients who had dysbiosis of intestinal flora caused by GP chemotherapy for inoperable NSCLC and were treated in our hospital from May 2013 to October 2016 were enrolled in the study. By the random number table method, they were divided into the control group and the study group, 49 cases in each group. The control group were treated with routine drugs, and the study group were treated with Bacillus Licheniformis Capsule. The intestinal flora, clinical efficacy, quality of life ［Karnofsky Performance Status (KPS) score］, adverse reactions and follow-up survival rate in the two groups were observed after treatment. Results There were no significant differences in Lactobacillus, Bifidobacterium, Enterobacteriaceae, Enterococcus and KPS between the two groups before treatment. After treatment, Lactobacillus, Bifidobacterium and KPS scores increased significantly, and Enterobacteriaceae and Enterococcus decreased significantly in the two groups, and the changes were more obvious in the study group than in the control group. After treatment, the total effective rate of treatment in the study group was significantly higher than that in the control group (85.71% vs 67.35%), and there was no significant difference in the total incidence of adverse reactions between the two groups. The survival rate of the study group was significantly higher than that of the control group in 6 months of follow-up. Conclusion The application of Bacillus Licheniformis Capsule in the treatment of dysbiosis of intestinal flora caused by GP chemotherapy for inoperable NSCLC can effectively regulate the intestinal flora, and improve clinical efficacy, quality of life and survival, with certain safety.

 Objective To study the effects of Butyphthalide on neurological function, Oxidative Stress and hemodynamics in Patients with Cerebral Infarction. Methods Retrospective analysis from June 2016 to June 2017 in 120 cases of patients with cerebral infarction in our hospital, regular group (60 cases) and study group (60 cases) according to the principle of random grouping, the rats in the conventional group were treated with conventional butt phthalide, and the clinical efficacy and neurological function, oxidative stress and hemodynamic changes were analyzed and compared before and after treatment. Results The total effective rate was96.6% in the study group, significantly better than the conventional group, There was no significant difference in the CSS scores between the two groups. After 3 weeks of treatment, the CSS scores of the regular group and the study group decreased as compared with those before treatment, but the decline of the CSS score of the study group was more significant than that of the conventional group. There was no significant difference in serum MDA, CAT, SOD between the two groups before and after treatment . After 3 weeks of treatment, the level of MDA in study group decreased, The level was more significant than the conventional group. Before treatment, there was no significant difference in serum NGF, NSE and NTF between study group and control group. After 3 weeks of treatment, serum NSE level of study group was lower than that of routine group and study group. After 3 weeks of treatment, the levels of serum NGF and NTF in the routine group and the study group increased compared with those before treatment, but the levels of NGF and NTF in the study group were significantly higher than those in the conventional group. The systolic blood flow velocity (Vs), mean blood flow velocity (Vm) and pulsatility index (PI) of two groups before treatment did not differ significantly. After treatment, systolic blood flow velocity, mean blood flow velocity. The pulsatility index of the study group was significantly lower than that of the conventional group. Conclusion The innovative point of this paper is to observe the effects of butylphthalide on the neurological function, oxidative stress and hemodynamics in addition to observing the clinical efficacy of butylphthalide in patients with cerebral infarction and to explore the possible mechanisms involved in the treatment of cerebral infarction with butylphthalide .

Objective to investigate the effect of tissue flap transfer for mammary cancer after breast conserving surgery on breast aesthetics and quality of life. Methods From April 2013 to June 2017 in our hospital diagnosis and treatment of 52 cases of female patients with primary breast cancer, according to the wishes of patients and their families, 52 cases primary breast cancer were divided into control group (n=23) and study group (n=29), the control group in the patients with breast cancer after breast conserving surgery received conventional basic treatment, patients in study group were treated with breast conserving surgery in breast cancer immediately, the flap flap transfer surgery. To observe the curative effect of two groups of patients, postoperative complications, psychological status and aesthetic score. Analysis of the effect of breast tissue flap transposition surgery of breast conserving surgery in patients with breast aesthetics and quality of life. Results After surgical treatment, the patients with breast symmetry, surface roughness, skin effect, nipple moving distance of individual scores in study group was significantly higher than control group , and the total scores of study group were significantly higher than control group . Two groups of patients with breast skin color and the incision scar, difference was no statistically significant . After operation, there was 1 cases distant metastasis in control group, and no distant metastasis in study group. There was no local recurrence in two groups. the control group had 1 cases wound infection, and 1 cases wound effusion; the study group appeared 2 cases wound infection, 1 cases wound hematoma. The difference between the two groups was not statistically significant . The pain of the patients in the study group was significantly reduced, and the quality of life was significantly better than control group . Conclusion Using tissue flap to repair breast defects after breast conserving surgery can avoid severe breast deformation, and effectively maintain the appearance and shape of the breast, improving the patient’s quality of life It is worth to popularizing and applying.

Objective To investigate the effect of nerve growth factor (NGF), transforming growth factor β1(TGF- β1), fibroblast growth factor (FGF) in fracture healing. Methods Selected 30 male New Zealand rabbits, were randomly divided into 5 groups, including saline group, NGF group, TGF-β1 group, FGF group, NGF+FGF+TGF-β1 group, 6 rabbits in each group, tibial fracture model was established in all animals. The saline group, NGF group, TGF-β1 group, FGF group, NGF+FGF+TGF-β1 group after operation in the fracture site were injected saline, NGF, TGF-β1, FGF and NGF+FGF+TGF- β1, observed each group the X-ray score, bone mineral density and osteocalcin levels. Results Postoperative 14d, 21d and 28d, NGF group, TGF-β1 group, FGF group, NGF+FGF+ TGF-β1 group X-ray score, bone density and serum osteocalcin were significantly higher than those in the saline group; Postoperative 21d and 28d, NGF+FGF+TGF-β1 group X-ray scores were (15.63±0.92) and (16.01±0.93), significantly higher than that of NG group F, TGF-β1 group and FGF group; Postoperative 14d, 21d and 28d NGF+FGF+TGF- β1 groups bone density were (0.604±0.019) g/mm², (0.613±0.021) g/mm² and (0.644±0.016) g/mm², significantly higher than that of NGF group, TGF- β1 group and FGF group; Postoperative 14d, 21d and 28d NGF+ FGF+ TGF-β1 groups serum osteocalcin were (10.236±0.121) ng/ml, (11.924±0.093) ng/ml and (13.210 ±0.083) ng/ml, significantly higher than that of NGF group, TGF-β1 group and FGF group. Conclusion NGF, TGF-β1 and FGF has a certain role in promoting fracture healing, them has a strong synergistic effect, can obviously promote fracture healing.

Objective To explore the clinical efficacy of Feilike mixture combined with budesonide formoterol powder inhalants in the treatment of cough variant asthma (CVA) and its effect on airway inflammation. Methods A total of 72 patients with CVA enrolled in Respiratory Medicine Beijing First Hospital of Integrated Chinese and Western Medicine were selected for the study and randomly divided into the control group (n=36, treated with budesonide formoterol powder inhalants) and the experimental group (n=36, treated with budesonide formoterol powder inhalants and Feilike mixture). The clinical efficacy, pulmonary function, airway inflammation and adverse reactions were compared between the two groups. Results The total effective rate was 94.44% in the experimental group, which was significantly higher than that in the control group with 77.78%. After treatment, the day or nocturnal cough symptom scores, one-second forced expiratory volume (FEV1), FEV1/forced vital capacity (FVC), the ratio of PEF (PEF pred%) and interleukin-10(IL-10) level were significantly higher than those before treatment, After treatment, the levels of the eosinophil (EOS) percentage, inflammatory mediators interleukin-4(IL-4) and interleukin-5(IL-5) were significantly decreased in the two groups, and the changing degree in the experimental group was significantly higher than that in the control group. There was no significant adverse reaction between the two groups as well as the incidence rate of adverse reactions. Conclusion The use of Feilike mixture combined with budesonide formoterol powder inhalants can have significant effects in the treatment of CVA children, such as relieving the cough symptoms of children and improving lung function and airway inflammation with high safety.

Objective To study the efficacy and safety of celecoxib combined with methotrexate in the treatment of rheumatoid arthritis. Methods A total of 100 patients with rheumatoid arthritis who were treated in our hospital from April 2014 to May 2016 were selected as subjects. All patients were divided into study group and control group according to the random number table method, each group of 50 cases. The control group was treated with methotrexate. The study group was treated with celecoxib on the basis of the control group. The levels of arthritis, inflammatory factors (IL-1, IL-6), the number of joint swelling and the incidence of adverse reactions were observed and compared between the two groups before and after treatment. Results The VAS scores of the two groups were lower than those before the treatment, and the difference was statistically significant. The levels of IL-1 and IL-6 in the two groups were lower than those before treatment, and the difference was statistically significant. The number of joint swelling after treatment in the two groups was less than that before treatment, and the study group was less than the control group, the difference was statistically significant; There was no significant difference in the incidence of adverse reactions between the two groups ［8.0% vs12.0%］. Conclusion Celecoxib combined with methotrexate in the treatment of rheumatoid arthritis with significant efficacy, high safety, can effectively reduce the inflammatory response, reduce joint pain in patients with joint swelling, reduce the number of joint swelling, improve patient quality of life, worthy of clinical promotion.

Objective To investigate the effect of percutaneous transluminal angioplasty (PTA) combined with endovascular stent for lower extremity arteriosclerosis obliterans (ASO) curative effect and vascular endothelial function and inflammatory factors. Methods From March 2013 to June 2016, 102 cases of patients with ASO were treated in our hospital, considered as the research object. According to the treatment methods, 102 cases of patients were divided into the control group (n=50) and the observation group (n=52). The control group conventional treatment, the observation group in the control group based on the PTA stent in the treatment of combined endovascular. Clinical efficacy and vascular endothelial function and inflammatory factor level of two groups were compared. Results Observation group total the efficiency was 78.85% and higher than control group . Before treatment, two groups of endothelin-1(ET-1), nitric oxide (NO) and nitric oxide synthase (NOS) were not statistically significant difference. After treatment, the two groups of ET-1 and NO and NOS level were slightly lower than before treatment. After treatment, the margin changes of ET-1, NO and the level of NOS in observation group were slightly less than the control group. The two groups before treatment of β2- microglobulin (β2-M), tumor necrosis factor α (TNF-α), interleukin-6(IL-6) and high sensitivity C reactive protein levels were no significant difference. After treatment, the β2-M. IL-6 and TNF-α, hsCRP level in two groups were lower than before treatment, and the observation group of β2-M, TNF-α, IL-6 and hsCRP levels were lower than the control group. Conclusion PTA combined with endovascular stent in the treatment of lower extremity ASO has obvious curative effect, can reduce the patients with β2-M and other inflammatory factors, and little effect on blood vessels endothelial function.

 Objective To analyze the risk factors of deep venous thrombosis in patients undergone hip replacement, and to investigate the application value of Autar Scale risk assessment. Methods A total of 101 cases of patients admitted to hospital from January 2015 to December 2016 and undergone hip replacement were selected as the research objects. The methods of single factor and multi-factor logistic regression analysis were used to analyze the risk factors of deep venous thrombosis in those patients, and Autar Scale was used to assess the risk degree of deep venous thrombosis. Results Among the 101 cases of patients, 15 cases had postoperative deep venous thrombosis, with the incidence rate of 14.85%. Single factor analysis showed that the incidence rate of deep venous thrombosis in female patients and patients with complicating diseases (hypertension, diabetes, cardiovascular and cerebrovascular diseases) was significantly higher than that of patients without deep venous thrombosis; the incidence rate of patients with postoperative early activities and postoperative use of anticoagulants was significantly lower than that of patients without deep venous thrombosis; the incidence rate of aged patients was significantly higher than that of patients without deep venous thrombosis. Multi-factor logistic regression analysis showed that female, advanced age, complicated hypertension, diabetes and cardiovascular and cerebrovascular disease are risk factors of deep venous thrombosis after hip replacement, postoperative early activities and postoperative use of anticoagulants are protective factors that prevent deep venous thrombosis; the incidence rate of deep venous thrombosis in high risk patients was significantly higher than that of low risk and medium risk patients; the incidence rate of deep venous thrombosis in medium risk patients was significantly higher than that in low risk patients. Conclusion The incidence rate of deep venous thrombosis in patients undergone hip replacement is high, and it is significantly correlated with gender, age and complicating diseases. The risk assessment on deep venous thrombosis should be strengthened, and predictable and targeted nursing intervention strategies should be proposed to reduce the incidence rate of deep venous thrombosis.

Objective To observe the clinical effect of BIPAP of noninvasive ventilation in the treatment of COPD with left ventricular failure and pulmonary edema on the basis of conventional diuresis, cardiac and central excitatory drugs such as furosemide, digitalis and canola. Methods The clinical data of 135 patients with COPD complicated with left heart failure pulmonary edema from January 1, 2014 to December 31, 2016 in our hospital were retrospectively analyzed, and the patients were divided into observation group (n=68) and control group (n=67) according to different treatment methods. Among them, the control group was treated with furosemide, digitalis, canola and other conventional diuresis, cardiac and central excitatory drugs for treatment, while the observation group added BiPAP treatment based on the control. The general clinical indicators at 2 hours after the treatment, the treatment effect, cardiac function improvement and of lung function improvement at 3 months after the treatment of the two groups were compared. Results Two hours after the treatment, the levels of SBP, SDP, HR, PaO₂, PaCO₂, SaO₂ and Brog dyspnea score in the observation group were significantly better than those in the control group. Three months after the treatment, the total effective rate was 92.65% in the observation group, which was significantly higher than 79.10% in the control group; the cardiac parametersof LVEF, 6 min walking distance and BNP level in the observation group were significantly better than those in the control group, the lung function indexes of FEV₁, FEV₁/FVC and FEV₁% Pred in the observation group were significantly better than those in the control group. Conclusion For patients with COPD complicated with left heart failure and pulmonary edema, BiPAP treatment combined with conventional diuresis, cardiac and central excitatory drugs such as furosemide, digitalis and canola can significantly rapidlyrelieve the clinical symptoms of patients, improve the patient’s heart and lung function, and the treatment effect is better.

Objective To analyze the application of multislice spiral CT three-dimensional angiography in abdominal vascular disease and its effect on prognosis. Methods A retrospective study was conducted. From November 2014 to October 2016, 76 patients with abdominal vascular diseases admitted to our hospital were selected and divided into two groups according to different diagnostic methods: experimental group and control group (38 patients in each group). Multi-slice spiral CT angiography was used in the experimental group, and the control group was diagnosed by color Doppler ultrasonography. SPSS20.0 statistical software for statistical analysis of the two groups of patients the correct diagnosis rate (in order to compare the pathological diagnosis of experimental and control groups, the two groups the correct diagnosis rate). Results The correct diagnosis rate of the experimental group was 97.37% (37/38, 10 cases of portal vein disease, 5 cases of abdominal aortic aneurysm, 5 cases of splenic hemangioma, 6 cases of hepatic hemangioma, 7 cases of renal artery calcification stenosis, 2 cases 1 case of calcific stenosis of superior mesenteric artery and 1 case of calcified stenosis of aorta), the correct diagnosis rate of the control group was 81.58% (31/38, 4 cases of portal vein disease, 2 cases of abdominal aortic aneurysm, 2 cases of splenic artery 4 cases of renal artery calcification stenosis, 5 cases of abdominal aortic calcification stenosis, 3 cases of superior mesenteric artery calcification stenosis, 3 cases of calcified artery stenosis), experimental group, the correct diagnosis rate is much higher than the control group. Conclusion Multislice spiral CT three-dimensional angiography in the abdominal vascular disease is of high value, can be multi-directional observation of abdominal vascular disease vascular running conditions.

Objective to investigate the role of renal artery resistance index (RRI) in patients with sepsis complicated with acute kidney injury (AKI). Method Critically ill patients diagnosed from March 2014 -2017 year in February from ICU in 150 cases of sepsis as observation object, according to the KDIGO standards are divided into four groups, 51 cases without AKI as group A, 43 cases of AKI 1 as B group, 35 cases of AKI 2 as C group, 21 cases of AKI the 3 stage is the D group. The RRI patients were determined by ultrasound, Scys C and Ucys C by immunoturbidimetric assay, determination of SCr. of all the data were analyzed by ELISA. Result The group A 1D RRI, Scys C, Ucys C and SCr and B group were no significant difference, the 2、3d was significantly different; group C 1、2、3d RRI, Scys C, Ucys C and SCr were significantly higher than that in A group and B group D; group 1、2、3d RRI, Scys C, Ucys C and SCr were significantly higher than the other three groups; correlation analysis showed that RRI and Scys C, Ucys C and SCr each time were positively correlated. Conclusion Ultrasonography can effectively reflect the degree of renal damage in sepsis patients complicated with AKI.

Objective To investigate the Seretide in the treatment of moderate and severe COPD (Chronic obstructive pulmonary disease) to improve lung function in patients with you, inflammation status and clinical therapeutic effect. Methods 70 cases of patients with severe COPD from December 2015 to December 2016 in our hospital, according to the different treatment methods were divided into two groups, 35 cases in each group, two groups of patients were given conventional treatment, the control group was given the treatment of Theophylline Sustained-release Tablets, on the basis of the observation group patients were given Seretide treatment, observe two groups of patients before and after treatment, lung function, inflammatory factors expression, dyspnea score the changes recorded in patients with clinical efficacy after treatment, and compared. Results After treatment, the pulmonary function indexes such as FEV1, FVC and FEV1/FVC were improved, and the difference between the two groups was statistically significant; the expression levels of inflammatory factors in the treatment of patients before the comparison, no statistically significant; after the treatment, the expression level of serum inflammatory factors in patients with IL-6, CRP and TNF- etc were decreased, the observation group than the control group, the difference was significant after treatment; , dyspnea score of patients were lower than those before treatment, the observation group (1.56+0.32) lower than that of control group (1.98 + 0.42), significant difference; after treatment, the total effective rate was 94.29% higher than 71.43% in the control group, significant difference the adverse reactions of the observation group was 5.71%, which was lower than that of the control group (22.86%), and the difference was significant. Conclusion Given the severe Seretide treatment in patients with COPD, can improve the patient’s lung function, relieve the symptoms of breathing difficulties, inhibit the expression of inflammatory cytokines, significant effect.

 Objective To investigate the effect of epidural anesthesia combined with general anesthesia on hemodynamics and stress status in elderly patients with hypertension. Methods One hundred and eighteen elderly patients with hypertension treated by laparoscopic cholecystectomy from January 2014 to January 2017 were selected, and were randomly divided into group A and group B, fifty-nine cases in each. General anesthesia was used in group A, while epidural anesthesia combined with general anesthesia was used in group B. The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and oxygen saturation (SpO₂) before anesthesia (T0), after intubation (T1), 10min after pneumoperitoneum (T2), and before extubation (T3) were compared between the two groups. The levels of growth hormone (GH), prolactin (PRL) and cortisol (Cor) in T0, T1, T2 and T3 were compared between the two groups. The breathing recovery time, awake time and extubation time after operation were compared between the two groups. The incidence of emergence delirium were compared between the two groups. Results The SBP, DBP and HR of the two groups in T1, T2 and T3 were significantly higher than those in T0. The SBP and DBP of group B in T1 T2 and T3 were significantly lower than those of group A, while the HR was significantly higher than that of group A. The levels of GH, PRL and Cor of group B in T1, T2 and T3 were significantly lower than those of group A. The breathing recovery time, awake time and extubation time after operation of group B were significantly less than those of group A . The incidence rate of emergence delirium of group B was 6.78%, which was significantly lower than that of group A. Conclusion Epidural anesthesia combined with general anesthesia is more conducive to maintaining the stability of hemodynamics in elderly patients with hypertension. It can reduce the stress response and shortening the postoperative recovery time.

 

 Objective To study the tumor markers carcinoembryonic antigen (CEA) and squamous cell carcinoma associated antigen (SCCAg), neuron specific enolase (NSE) in advanced non-small cell lung cancer, in the process of evaluation of the efficacy of clinical application. Methods 78 cases of advanced non-small cell lung cancer patients as the research object, according to the targeted therapy after curative effect is divided into partial remission group 39 cases, 24 cases of stable disease group, 15 cases in group, compared three groups of subjects targeted drug therapy before and after eight weeks of treatment, tumor markers CEA, SCCAg and NSE in serum the level changes of tumor markers in evaluating the therapeutic effect of clinical application. Results The results of different pathological types of non-small cell lung cancer tumor markers: CEA increased statistically in any group of squamous cell carcinoma, squamous adenocarcinoma and adenocarcinoma; SCCAg increased and there was significant difference in any group in adenocarcinoma, squamous adenocarcinoma, squamous cell carcinoma; NSE is the highest in adenocarcinoma, no statistically significant difference in squamous cell carcinoma, squamous adenocarcinoma; partial remission group of patients with non-small cell lung cancer tumor markers CEA, SCCAg, NSE serum levels were decreased, the difference was statistically significant; stable disease group non-small cell cancer tumor markers CEA, SCCAg and NSE serum levels no significant change; partial remission in patients with tumor progression of non-small cell carcinoma markers CEA, SCCAg, NSE serum levels were elevated, the difference was statistically significant. Conclusion The monitoring of tumor markers is a reliable approach to understand the effectiveness of molecular targeted therapies, and is also the basis for molecular targeted drug selection.

 Objective To observe the effects of propofol combined with atracurium cis-benzenesulfonate on muscle relaxation and hemodynamics in patients undergoing laparoscopic cholecystectomy (LC). Methods 90 patients with LC were randomly divided into the control group (n=45) and the observation group (n=45) according to the lottery method. Both groups were induced by anesthesia. The control group was given propofol combined with vecuronium anesthesia. The observation group given propofol combined with triptolide sulfonate anesthesia, and other auxiliary anesthesia drugs are the same. The effect of muscle relaxation and tracheal intubation in two groups of LC patients are observed. During after anesthesia (T0), endotracheal intubation (T1), cutaneous (T2), extubation (T3) and extubation (T4), the changes in hemodynamics were measured. Result The onset time and muscle relaxation recovery time of the muscle relaxants in the observation group were significantly lower than those in the control group. The clinical time and the rate of tracheal intubation were significantly higher in the observation group than in the control group, and the difference was statistically significant. At T0, there were no significant differences in the hemodynamic indexes between the two groups. At T1, T2, T3 and T4, the systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) of the observation group were significantly lower than those of the control group, and compared with T0 was no significant difference. While the control group SBP, DBP and HR levels was significantly higher than T0, and the difference was statistically significant. Conclusion Acetylcidate sulfonate combined with propofol anesthesia, has good muscle relaxion effect and high level of tracheal intubation assessment, and can stabilize hemodynamics, which is one of the clinical effective LC anesthesia program.

 Objective To study the clinical efficacy of Er: YAG laser in combination with periodontal treatment of chronic periodontitis and its effect on cytokines in gingival crevicular fluid. Methods 120 cases of chronic periodontitis patients admitted to the Second Hospital of Shijiazhuang City from August 2016 to July 2017 were selected as the subjects of this study. All the patients according to random number table method is divided into traditional medicine group and laser group, each group of 60 cases. The patients in the Traditional medicine group were given conventional periodontal basis of treatment, and the patients in the Laser group patients were given Er: YAG laser combined with periodontal for treatment. The clinical indicators of periodontal before and after treatment and the changes of cytokine levels in gingival crevicular fluid in both groups were observed and compared. Results Before the treatment, there was no significant difference in periodontal clinical parameters between the two groups. After treatment, the levels of periodontal clinical parameters (BI, PD, CAL) in both groups were lower than those before treatment, and the laser group was lower than the traditional group. The difference was statistically significant. The levels of cytokines (IL-6, IL-8, TNF-α) in gingival crevicular fluid before treatment in both groups showed no significant difference. After treatment, the levels of IL-6, IL-8 and TNF-α in both groups were lower than those before treatment, and the difference between the two groups was statistically significant. Conclusion Er: YAG laser combined with periodontal treatment of chronic periodontitis significant clinical efficacy, can effectively reduce the patient’s periodontal inflammatory response to improve the patient’s gingival bleeding, deserved clinical promotion.

Objective To research the clinical application of ultrasonography combined with the detection of hs-CRP and CA125 in the diagnosis of endometrial cancer. Method 107 cases of endometrial carcinoma in our hospital were selected as the research objects. According to the FIGO staging criteria, they were divided into the stage Ⅰ~Ⅱ (58 cases) and the stageⅢ~Ⅳ (49 cases). The levels of serum hs-CRP, CA125 and the positive rate in different stages were compared. The diagnostic ability of ultrasonography combined with hs-CRP and CA125 in endometrial carcinoma were evaluated by ROC curve. Result The levels of hs-CRP and CA125 in patients with stage Ⅰ~Ⅱ were significantly lower than those of stage Ⅲ~Ⅳ, the FIGO staging was positively correlated with the levels of hs-CRP and CA125, and the differences were statistically significant. The positive rate of hs-CRP, CA125 and hs-CRP combined with CA125 in patients with stage Ⅰ~Ⅱ were were significantly lower than that those in stage Ⅲ~Ⅳ, the differences were statistically significant. The sensitivity and specificity of ultrasound combined with hs-CRP and CA125 was significantly greater than that of ultrasound combined with hs-CRP and ultrasound combined with CA125. Conclusion Transvaginal ultrasound can detect suspicious endometrial cancer lesions. Combined detection of serum hs-CRP and CA125 can helpful for the early diagnosis of endometrial cancer, and can significantly improve the clinical detection rate of endometrial cancer, thereby reducing the misdiagnosis and misdiagnosis.

 Objective To investigate the the eherapeutic effect of Xiaojin tablets in the treatment of Breast hyperplasia in serum vascular VEGF and bFGF. Methods 114 breast hyperplasia patients in our hospital from August 2013 to December 2016 were selected and randomly divided into 2 groups. The control group was treated with tamoxifen and vitamins, the study group was treated more with Xiaojin tablets, and 2 groups were treated for 4 monthes. Blood samples were collected to detect vascular endothelial growth factor, Basic fibroblast growth factor, bFGF by Enzyme-linked immunosorbent assay before treatment and after treatment, levels of estradiol (E2), progesterone (P) and prolactin (PRL) were measured by Radioimmunoassay, and the clinical effects between 2 groups were compared. Result Compared with before treatment, levels of serum VEGF and bFGF in 2 groups decreased, the levels of serum E2 and PRL values decreased, and the serum P value increased, compared with the control group, levels of serum VEGF and bFGF in the study group were lower, the levels of serum E2 and PRL were lower, and the serum P was higher, the effective rate of the control group 78.95% was lower than the study group92.98%, the adverse rate in the control group7.02% and the study group 3.51% had no difference. Conclusion Xiao Jin tablet was effective in the treatment of hyperplasia of mammary glands, which was helpful to reduce the serum VEGF and bFGF values, inhibit angiogenesis, improve the sex hormone indexes, and the adverse reactions can be tolerated.

 Objective Effects of azithromycin combined with cefodiazine sodium on clinical symptoms and inflammatory status in patients with pulmonary infection. Methods Selected 112 cases of pulmonary infection from March 2014 to March 2016, randomly divided into observation group and control group, analysis of the improvement of clinical symptoms and inflammatory status in the two groups. Results After treatment in the observation group and the control group, the remarkable effect was 33(58.93%), 25(44.64%); the effective was 18(32.14%), 17(30.36%); the invalid was 5(8.93%), 14(25.00%); the total effective rate was 51(91.07%), 42(75.00%), there was significant difference. After treatment, there were significant differences in cough and expectoration, acute asthma, fever and lung rale disappearance between the observation group and the control group. After treatment, compared with the control group, the average of NO, SP-A and HMGB1 in the observation group decreased significantly, and the level of ChE increased significantly. After treatment, the serum levels of PAF, TNF-α, IL -6, MIP-1α, CRP and PCT decreased significantly in the observation group compared with the control group. The adverse reactions of the observation group and the control group were nausea and vomiting 2(3.57%), 1(1.79%), abdominal distention and diarrhea 1(1.79%) and 1(1.79%). Conclusion The combination of azithromycin and cefodizime sodium can improve the clinical symptoms of the patient, reduce the inflammatory state, and has good safety.

Objective To study the effect of Chinese acupuncture and moxibustion combined with massage therapy on cervical spondylosis of vertebral artery and its effect on the quality of life of patients. Methods 200 cases of patients with vertebral artery type cervical spondylosis who were treated in our hospital from March 2017 to March 2017 were selected as the subjects. All the patients were divided into control group and study group according to the random number table method, each group of 100 cases. The patients in the control group were received traditional Chinese medicine acupuncture treatment, and the patients in the study group were given traditional Chinese medicine acupuncture combined with massage therapy. The clinical symptom scores, quality of life improvement and clinical efficacy were compared between the two groups before and after treatment. Results There was no significant difference in the clinical symptom scores between the two groups before treatment. After treatment, the shoulder and neck pain, dizziness and headache scores of the two groups were higher than those before treatment, and the study group was higher than the control group, the difference was statistically significant; There was no significant difference in QLQC30 score between the two groups before treatment. The QLQC30 scores of the two groups were higher than those before treatment, and the study group was higher than the control group, the difference was statistically significant; The total effective rate was 95.0% (95/100) in the study group and 86.0% (86/100) in the control group, the difference was statistically significant. Conclusion Chinese Acupuncture and moxibustion combined with Massage on Cervical Spondylosis of Vertebral Artery Type effect is significant, can effectively relieve clinical symptoms, improve the quality of life of patients, it is worth promoting.

Objective To study the effect of craniocerebral drilling and drainage in the treatment of severe craniocerebral injury complicated with hypertensive intracerebral hemorrhage and its effect on neurological function. Methods 200 cases of patients with severe craniocerebral injury complicated with hypertensive intracerebral hemorrhage who were treated in our hospital from January 2015 to December 2016 were enrolled in this study. According to the different surgical methods, 90 patients were divided into control group and 110 patients in the study group. The patients in the control group were treated with craniotomy and craniotomy. The patients in the study group were treated with craniotomy and drainage. The patients were followed up for 1-3 months. The operative time, postoperative hospital stay, postoperative rebleeding rate and neurological function before and after operation were compared between the two groups. Results The operative time and postoperative hospital stay were lower in the study group than those in the control group. The rate of rebleeding was lower in the study group than in the control group, but there was no significant difference. The neurological function NIHSS score of the two groups was lower than that of the control group at 1 month after operation, and the difference was statistically significant. The total effective rate of the study group was 91.8% (101/110) higher than that of the control group (77.8%, 70/90), the difference was statistically significant. Conclusion Brain drilling and drainage surgery for severe craniocerebral injury complicated by hypertensive intracerebral hemorrhage significantly, short operation time, can effectively reduce the body damage, improve the patient’s neurological function, promote patient rehabilitation.

Objective To investigate the relationship between body mass index (BMI) and absolute renal risk (ARR) in IgA nephropathy. Methods The clinical data of 82 patients with IgA nephropathy admitted in our hospital from January 2012 to August 2017 were retrospectively analyzed. The relationship between BMI and ARR was analyzed. Patients were divided into healthy group (18.5 kg / m2 ≤ BMI <24 kg / m2, 38 cases), overweight group (24 kg / m2 ≤ BMI <28 kg / m2, 28 cases) and obese group (BMI≥28 kg / m2, 16 example). Results There were significant differences in sex, age, diabetes mellitus, hypertension, ARR score, serum uric acid, Scr, BUN and Cys C in healthy group, overweight group and obesity group. There were significant differences in renal vascular score between healthy group, overweight group and obese group. There was no significant difference in glomerular score, renal tubulointerstitial score and total score between the two groups. Multivariate and multivariate logistic regression analysis showed that BMI was an independent risk factor for ARR in patients with IgA nephropathy (OR = 1.423, 95% CI: 1.130 ～ 3.736). Conclusion Obesity is a risk factor for elevated ARR in IgA nephropathy, and obesity may indicate poor prognosis.

Objective To observe the effect of pancreatic kininogenase tablets assisted with ulinastatin on microcirculation disorder in patients with acute pancreatitis. Methods 100 cases of patients with acute pancreatitis were randomly divided into the observation group and the control group according to the random number table method, with 50 cases in each group. The patients in the control group were treated with ulinastatin injection of 100, 000 units plus 5% glucose injection and the patients in the observation group were given pancreatic kininogenase on the basis of treatment in the control group, and the course of treatment was 2 weeks. The clinical efficacy of the two groups, the levels of TNF-α, PFA, IL-6, IL-10, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, erythrocyte sedimentation and other hemorheological indexes, thrombin time (TT), prothrombin time (PT), partial activated thrombin time (APTT), D-dimer and other coagulation function and the occurrence of adverse reactions were observed and compared between the two groups before and after treatment. Results The total effective rate of the observation group (94%) was significantly higher than that of the control group (76%). The expression levels of TNF-α, PFA, IL-6 and IL-10 in the two groups were significantly lower than those before treatment, and the expression levels of TNF-α, PAF, IL-6 and IL-10 in the observation group were significantly lower than those in the control group. After treatment, the whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and erythrocyte sedimentation indexes were significantly lower than those before treatment, and the hemorheological indexes of the observation group were significantly lower than those in the control group. The coagulation function indexes of TT, PT, APTT and D-dimer in the two groups were significantly longer than those in the control group, and the coagulation function indexes of the observation group was significantly longer than those of the control group. There was no significant difference in the incidence rate of adverse reactions between the two groups. Conclusion Pancreatic kininogenase tables assisted with ulinastatin can effectively improve the clinical symptoms of patients with acute pancreatitis, can dilate the blood vessels by reducing the levels of inflammatory factors and coagulation function to improve microcirculation disorder without increasing the adverse reactions. Therefore it is worthy of clinical promotion and application.

 Objective To investigate the effect of different anastomotic surgeries on the incidence of complications after pancreaticoduodenectomy (PD). Methods The clinical data of 100 patients treated with PD by pancreatic duct jejunal mucosa anastomosis (group A, n=38), encasing pancreatic and intestinal anastomosis (group B, n=32) and pancreatic jejunal bundle anastomosis (group C, n=30) were retrospectively analyzed. The incidence of postoperative complications and the severity of pancreatic fistula were compared. The pancreatic exocrine function indexes at 1 year after surgery ［fecal elastase (FE) ］, endocrine function indexes ［glucagon (GLC), somatostatin (SS) ］, nutritional status indexes ［body mass index (BMI), serum albumin, prealbumin］ and the quality of life score ［Functional Assessment of Cancer Therapy-General (FACT-G) ］ were recorded. Results There was no perioperative death in the three groups. The incidence of postoperative complications showed group C < group A < group B. The incidence of pancreatic fistula and grade C rate were significantly lower in group C than the other two groups, but there was no significant difference between group A and group B.1 year after surgery, there were no significant differences among the three groups in pancreatic exocrine function indexes, pancreatic endocrine function indexes and nutritional status. The FACT-G score showed group C > group A > group B. Conclusion The three anastomotic surgeries are of certain application value in PD, and pancreatic jejunal bundle anastomosis can effectively reduce the risk of postoperative complications, which is good for improving the quality of life of patients.

Objective To compare the effects of bridge combined internal fixation and locking compression plate fixation in the treatment of limb fractures. Methods A total of 70 patients with limb fractures were selected from January 2015 to July 2016 in our Hospital. The patients were randomly divided into the observation group and the control group with 35 cases in each group: The observation group was treated with bridging combined internal fixation and the control group was given locking compression plate internal fixation. After 6 months of follow-up, the general operation data between the two groups were compared and the Constant shoulder score, and Hss knee score, visual analogue scale (VAS) were used to assess application of the function and pain degree of shoulder and elbow joint between the two groups. And the quality of life was analyzed by the short form health survey (SF-36) and the postoperative complications were observed. Results The operative time and fracture healing time were shorter in the observation group than those in the control group. The Constant score and the Hss score of the two groups after operation were increased significantly compared with the preoperative group, but there was no significant difference between the two groups. The VAS score (2.17±0.25) in the observation group was significantly higher than that in the control group. The physiological and psychological scores and total score (88.34±1.67) of SF-36 in the 6 months after the operation were significantly higher in the observation group than those in the control group. The incidence rate of complications was 5.71% in the observation group at 6 months follow-up, which was lower than that in the control group with 22.86%. Conclusion Compared with locking compression plate internal fixation, bridging combined with internal fixation is better for the treatment of limb fractures and can significantly shorten the operation time, fracture healing time, and produce less intraoperative blood loss, low postoperative complications rate, and significantly improve patients quality of life, therefore it is worth clinical application.

 Objective To study the relationship between levels of homocysteine (HCY) and adiponectin (ADP) and carotid artery intima-media thickness (IMT) in patients with atherosclerotic cerebral infarction (ACI). Methods A total of 300 patients with ACI treated in the Department of Neurology, Dafeng Hospital of Chaoyang District, Shantou were enrolled in the study. After ultrasonic detection of carotid artery outer segment, the patients were divided into the normal endometrium group (85 cases), the mild stenosis group (140 cases) and the moderate to severe stenosis group (75 cases) according to different IMT. The HCY, ADP and IMT were compared among the three groups. Results The IMT of normal endometrium group was thinner than 0.9mm, and AS plaque score was 0. The proportion of carotid atherosclerosis, number of atherosclerotic plaques and plaque scores were significantly higher in the mild stenosis group and the moderate to severe stenosis group than the normal endometrium group. There were significant differences in HCY, ADP and IMT in the mild stenosis group and the moderate to severe stenosis group, compared with those in the normal endometrium group. With the increase of IMT, HCY increased while ADP decreased, and changes of above indexes in the moderate to severe stenosis group were greater than those in the mild stenosis group. With the increase of HCY and the decrease of ADP, IMT increased. Serum HCY was positively correlated with IMT while serum ADP was negatively correlated IMT. Serum HCY and ADP were independent risk factors of IMT thickening. Conclusion The increase of serum HCY and the decrease of ADP are the risk factors of IMT thickening. Serum HCY is positively correlated with IMT while serum ADP is negatively correlated with IMT.

 Objective To investigate the application value of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) in the diagnosis of benign prostatic hyperplasia (BPH) and prostate cancer (PCA). Methods 42 cases of patients with PCA confirmed by biopsy or surgical pathology (PCA group) and 38 cases of patients with BPH confirmed by surgery and follow-up (BPH group) in our hospital from May 2011 to June 2016 were enrolled in the study. DWI was performed before operation, and the b value was 800s/mm². The DWI and ADC images of the two groups were observed and compared. The ADC values of non-PCA invading the prostate tissues and BPH tissues were compared, and ADC values of peripheral carcinoma tissues of PCA and the prostate tissues of BPH were also compared. Results In BPH group, the gland hyperplasia and muscle fiber hyperplasia showed inhomogeneous high signal and inhomogeneous low signal on DWI and ADC images. PCA group showed high signal on DWI and low signal on ADC. There were no significant differences between the two groups in ADC values of normal peripheral zone, glandular hyperplasia, interstitial hyperplasia, bladder and obturator muscle. Compared with the ADC value of PAC peripheral zone, the ADC values of the peripheral zone, the central gland hyperplasia and central muscle fiber hyperplasia of BPH group were significantly higher. Conclusion DWI and ADC can provide quantitative information for the diagnosis of prostate cancer. They are convenient and simple to use, and can be used as assistant tools for clinical diagnosis.

Objective To investigate the prevalence and risk factors of chronic kidney disease (CKD) among adults in Hunan Province. Methods Using cross-sectional study, take the method of multistage sampling, the survey was performed in part of residents (aged≥18 years) from 5 cities of Hunan Province, data was obtained by questionnaire of risk factors of CKD, physical examination, and laboratory examination. Results The prevalence of chronic kidney disease in Hunan province was 10.81%, it increased with the growth of the age, the awareness rate among CKD population was 20.8%. The prevalence of albuminuria was 1.85%, and the prevalence of albuminuria in males were significantly higher than females, and it increased with age; The prevalence of hematuria was 7.40%, females were higher than males, there was a significant statistical significance about the prevalence of hematuria in different ages. The prevalence of reduced eGFR was 2.65%, There was a significant statistical significance about the prevalence of reduced eGFR both in different genders and ages. Multiple factor logistic regression analysis results show that age, high systolic blood pressure, diabetes were closely related to CKD. Conclusion The prevalence of chronic kidney disease (CKD) in the adult population of Hunan is similar to that in China. Age, high systolic blood pressure, diabetes were closely related to CKD.

Objective Investigate the composition and influencing factors of hospitalization expenses of gallstone patients. Method Epidata 3.1 was used for data double entry, and SPSS 18 software was used for statistical analysis. Results The average hospitalization days of patients with cholecystolithiasis were 11.43±3.24 days, The cost of patients is mainly composed of medicine expenses, operation fees and auxiliary examination fees, among them, expenses for drugs, surgery, and auxiliary examinations accounted for 42.71%, 18.72% and 12.61% respectively of hospital expenses. Conclusion The cost of hospitalization is mainly composed of medical expenses, examination fee and operation fee. The factors influencing hospitalization expenses include actual hospitalization days, postoperative complications, times of rescue and nursing level.

 

 Objective To evaluate the detectability of Rh weak (D) blood group antigen in External Quality Assessment (EQA) of Evaluatiaon Laboratory in Hunan province. Methods The indirect anti-human globulin tests anti-D (IgD) are field tested and surveyed by the stuff in Hunan Center For Clinical Laboratory (abbreviate Center), and The red blood cells of Rh weak (D) are tested by each laboratory in a way of microcolumn gel card method and tube method; The red blood cells of Rh weak (D) are tested by EQA Evaluatiaon Laboratory according to the report Clinical Laboratory Quality Assessment Requirements (GB/20032301-T-361) and PT Evaluation Protocols. Results Field testing and survey: The accordance rate of positive weak (D) in anti-human globulin card+anti-D (IgD) in field test and survey are obviously higher than the microcolumn gel card method and tube method ( (anti (IgM) ); 90% of EQA laboratories did not take Rh (D) negative test confirmation again, while 10% of EQA laboratories chose wrong methods and reagents during this process. EQA Evaluatiaon Laboratory: There are 407 laboratories, among of which 12 take Rh (D) positive test confirmation experiment, with only 2.7% in positive accordance rate; there are 60 blood transfusion management and maternal and child care institutions, among of which 2 take Rh (D) positive test confirmation experiment, with only 3.3% in positive accordance rate. The weak D positive accordance rate are lower than the standard with those three methods in EQA Evaluatiaon Laboratory, without any sense in statistics. Conclusion The EQA Evaluatiaon Laboratory has low level in the testing ability of Rh weak (D) blood type . Anti-human globulin test anti-D (IgD) is regarded as Rh (D) negative test confirmation after conventional serologic detection of Rh (D), especially in maternal and child health care institutions and blood transfusion management the confirmation experiments must be putted into effect.

 Objective Observation on the effect of ultramicro powder of Ophiocordyceps xuefengensis on the fertility of SD rats and the development of early embryo. Method According to the guiding for evaluation of drug reproductive toxicity, the toxicity of Ophiocordyceps xuefengensis superfine powder on the fertility and early embryo development of SD rats was tested. Results During the experiment, the intake and body weight of each group increased normally, and there was no significant difference in mating, fertility and early embryo development between the experimental and control group. There was no significant difference between the groups. Conclusion Under this experimental condition, the Ophiocordyceps xuefengensis superfine powder has no toxic effect on the fertility and early embryo development of SD rats.