Objective To investigate the effect of different anastomotic surgeries on the incidence of complications after pancreaticoduodenectomy (PD). Methods The clinical data of 100 patients treated with PD by pancreatic duct jejunal mucosa anastomosis (group A, n=38), encasing pancreatic and intestinal anastomosis (group B, n=32) and pancreatic jejunal bundle anastomosis (group C, n=30) were retrospectively analyzed. The incidence of postoperative complications and the severity of pancreatic fistula were compared. The pancreatic exocrine function indexes at 1 year after surgery ［fecal elastase (FE) ］, endocrine function indexes ［glucagon (GLC), somatostatin (SS) ］, nutritional status indexes ［body mass index (BMI), serum albumin, prealbumin］ and the quality of life score ［Functional Assessment of Cancer Therapy-General (FACT-G) ］ were recorded. Results There was no perioperative death in the three groups. The incidence of postoperative complications showed group C < group A < group B. The incidence of pancreatic fistula and grade C rate were significantly lower in group C than the other two groups, but there was no significant difference between group A and group B.1 year after surgery, there were no significant differences among the three groups in pancreatic exocrine function indexes, pancreatic endocrine function indexes and nutritional status. The FACT-G score showed group C > group A > group B. Conclusion The three anastomotic surgeries are of certain application value in PD, and pancreatic jejunal bundle anastomosis can effectively reduce the risk of postoperative complications, which is good for improving the quality of life of patients.