Objective To investigate the clinical effect of automatic eustachian tube blow + balloon dilatation in the treatment of secretory otitis media in patients with nasopharyngeal carcinoma radiotherapy. Methods 80 patients with nasopharyngeal carcinoma treated with secretory otitis media were enrolled from January 2014 to April 2016. According to the random number table method, the selected subjects were randomly divided into control group (42 cases) and observation group (38 cases). The patients in the control group were treated with tympanostomy. The patients in the observation group were treated with automatic eustachian tube bleed and balloon dilatation. The clinical efficacy of the two groups after 6 months of treatment, the 3-month, 6-month, 12-month Eustachian tube dysfunction score and the Valsalva test score, and the incidence of adverse events were observed. Results The clinical effective rate (94.74%) in the observation group was significantly higher than that in the control group (76.19%), the difference was statistically significant; Two groups of patients after 3 months, 6 months, 12 months were significantly lower than before treatment, the patients in the observation group had the same time ETQR-7 score were significantly lower than those in the control group; The Valsalva score was decreasing in the two groups at 3 months, 6 months, and 12 months, and the observation group was followed by the Valsalva score was significantly lower than that in the control group. The incidence of recurrence and the recurrence rate (7.89%) in the observation group were lower than those in the control group (42.86%), which was statistically significant. Conclusion The treatment of secretory otitis media in patients with nasopharyngeal carcinoma radiotherapy has significant clinical effect, which can effectively improve the Eustachian tube dysfunction and clinical symptoms, low recurrence rate, high safety and wide In clinical application.