Objective To investigate the the eherapeutic effect of Xiaojin tablets in the treatment of Breast hyperplasia in serum vascular VEGF and bFGF. Methods 114 breast hyperplasia patients in our hospital from August 2013 to December 2016 were selected and randomly divided into 2 groups. The control group was treated with tamoxifen and vitamins, the study group was treated more with Xiaojin tablets, and 2 groups were treated for 4 monthes. Blood samples were collected to detect vascular endothelial growth factor, Basic fibroblast growth factor, bFGF by Enzyme-linked immunosorbent assay before treatment and after treatment, levels of estradiol (E2), progesterone (P) and prolactin (PRL) were measured by Radioimmunoassay, and the clinical effects between 2 groups were compared. Result Compared with before treatment, levels of serum VEGF and bFGF in 2 groups decreased, the levels of serum E2 and PRL values decreased, and the serum P value increased, compared with the control group, levels of serum VEGF and bFGF in the study group were lower, the levels of serum E2 and PRL were lower, and the serum P was higher, the effective rate of the control group 78.95% was lower than the study group92.98%, the adverse rate in the control group7.02% and the study group 3.51% had no difference. Conclusion Xiao Jin tablet was effective in the treatment of hyperplasia of mammary glands, which was helpful to reduce the serum VEGF and bFGF values, inhibit angiogenesis, improve the sex hormone indexes, and the adverse reactions can be tolerated.