Journal of Hunan Normal University(Medical Science)

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Mechanism of CD44 regulation of HIF-1α/PLOD2 signaling pathway on epithelial- mesenchymal transition in clear cell renal cell carcinoma

YANG Tao, DING Yancai, MA Xiaoyun, LI Feiyu

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 1-7.

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Objective To investigate the effect of CD44 regulation of HIF-1α/PLOD2 signaling pathway on epithelial mesenchymal transformation in clear cell renal cell carcinoma (ccRCC). Methods The expression of CD44 in ccRCC tissues was analyzed by bioinformatics database. The expression of CD44 in ccRCC cells was detected by qRT-PCR. The expressions of epithelial- mesenchymal transition, metastasis-related proteins, and HIF-1α and PLOD2 were analyzed by Western blot. Cell proliferation, migration and invasion were detected by clonal formation assay and transwell assay respectively. Results D44 was significantly upregulated in ccRCC cells. Compared with shNT group, cell proliferation, migration and invasion ability of sh-CD44 group were significantly decreased, the expression of E-cadherin protein was increased, and the expressions of N-cadherin, MMP-2 and MMP-9 protein were decreased. Compared with the Vector group, the proliferation, migration and invasion of cells in the CD44-OE group were significantly enhanced, the expression of E-cadherin protein was decreased, and the expressions of N-cadherin, MMP-2 and MMP-9 protein were increased. In addition, the expressions of HIF-1α and PLOD2 were decreased in sh-CD44 group compared with shNT group. Compared with Vector group, the expressions of HIF-1α and PLOD2 in CD44-OE group were increased. The mRNA level of HIF-1α in the sh-CD44 group did not change, but VHL bound to HIF-1α increased, which promoted the degradation of HIF-1α protein. Compared with the Vector group, the promoter activity of PLOD2 in the CD44-OE group was enhanced. In addition, compared with Vector+DMSO group, the proliferation, migration and invasion of cells in CD44-OE+DMSO group were significantly improved. Compared with the CD44-OE+DMSO group, the proliferation, migration and invasion of cells in the CD44-OE+ PX-478 group were significantly reduced. In addition, compared with Vector+DMSO group, the expression of E-cadherin protein decreased, while the expressions of N-cadherin, MMP-2, MMP-9, HIF-1α and PLOD2 protein were increased in CD44-OE+DMSO group. Compared with CD44-OE+DMSO group, the expression of E-cadherin protein was increased in CD44-OE+PX-478 group, while the expressions of N-cadherin, MMP-2 and MMP-9, HIF-1α and PLOD2 protein were decreased. Conclusion The results of this study indicate the roles of CD44 in promoting the proliferation and metastasis of ccRCC cells. These results suggest that targeting CD44 or HIF-1α/PLOD2 pathways may be new targets for ccRCC therapy.

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MIR205HG upregulates KLF5 to mediate Gemcitabine resistance and poor prognosis in non-small cell lung cancer

XIE Yun, XIE Xin, ZHENG Liping, YANG Jipeng, YE Xiao

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 8-14.

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Objective The aim of this study is to systematically evaluate the expression level of lncRNA MIR205HG in non-small cell lung cancer (NSCLC) patients and its association with clinical features, and further explore whether MIR205HG affects the resistance of lung cancer cells to gemcitabine by regulating KLF5, thereby providing potential molecular targets for overcoming chemotherapy resistance. Methods Data from 81 NSCLC patients admitted to our thoracic surgery department from October 2019 to May 2021 were reviewed. The expression levels were compared in tumor tissue and adjacent tissues, and the prognosis of patients with different levels of expression of expression of expression of MIR205HG was compared. Survival analysis was also conducted. In vitro detection of MIR205HG expression levels in lung cancer cell lines, construction of MIR205HG overexpression and knockdown lung cancer cells, CCK-8 detection of cell proliferation, clone formation assay to detect cell clone formation ability, qRT PCR and Western blot detection of MIR205HG and KLF5 mRNA and protein expression. Compare the sensitivity of in in gemcitabine drug in SK-MES-1 and gemcitabine resistant cells (SK-MES-1/GR) and detect MIR205HG and KLF5 mRNA and protein expression levels in SK-MES-1 and SK-MES-1/GR. Using SK-MES-1/GR cells transfected with MIR205HG interference plasmid to detect gemcitabine drug sensitivity and KLF5 mRNA and protein expression levels. Results The expression level of MIR205HG in tumor tissue was higher than that of adjacent tissues. High expression of MIR205HG is associated with increased tumor staging and lymph node metastasis in patients. The prognosis of the MIR205HG high expression group was worse. The expression of MIR205HG in lung cancer cell lines SK-MES-1, NCI-H1703, NCI-H2170 and NCI-H226 was higher than in BEAS-2B cells. Inhibition of MIR205HG suppresses cell proliferation and colony formation ability of cells, and down-regulates the expression level of KLF5. The expression levels of MIR205HG and KLF5 were up-regulated in SK-MES-1/GR, and inhibition of MIR205HG increased cell sensitivity to gemcitabine. Conclusion MIR205HG is highly expressed in NSCLC and is associated with poor prognosis, suggesting its potential as a prognostic biomarker for adverse outcomes in NSCLC. The MIR205HG/KLF5 signaling axis serves as a key pathway mediating gemcitabine resistance in NSCLC. Targeting this axis holds promise as a novel strategy to overcome gemcitabine resistance in NSCLC.

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Therapeutic effect of ganoderic acid a on cerebral ischemia/reperfusion injury in rats

ZHANG Liang, ZHAO Haikang, LI Fei, ZHANG Lingxue, WEI Yao

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 15-22.

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Objective To explore the therapeutic effect and mechanism of Ganoderic acid A (GAA) on cerebral ischemia/reperfusion (I/R) injury in rats. Methods The I/R rat model was constructed by middle cerebral artery embolization. The I/R rats were divided into the model group, low-dose group (0.5 mg/kg GAA), medium-dose group (1 mg/kg GAA), high-dose group (2.5 mg/kg GAA) and the activator group (2.5 mg/kg GAA+0.1 mg/kg LPS), and the healthy SD rats were set as the sham operation group, with 15 rats in each group. The neurological function impairment of rats was scored, the volume of cerebral infarction was detected by TTC staining, brain tissue injury was detected by HE staining, neuronal injury was detected by Nissl staining, and neuronal apoptosis was detected by TUNEL staining. The levels of MDA, SOD, GSH-Px and ROS in rat brain tissues were detected by reagent kits. The protein expression levels of IL-1β, IL-18, TNF-α, NeuN, BDNF, TLR4, NF-κB, p-NF-κB and NLRP3 were detected by Western blot. Results Compared with the model group, the number of neurons and Nissl bodies, cerebral infarction volume fraction, neurological function score and neural cell apoptosis rate of rats in the low-dose, medium-dose and high-dose groups were all decreased, the protein levels of IL-1β, IL-18, TNF-α, TLR4, NLRP3 and p-NF-κB were all decreased, and the levels of NeuN and BDNF were all increased. The levels of SOD and GSH-Px were all increased, while the levels of MDA and ROS were all decreased. Compared with the high-dose group, activator treatment inhibited the therapeutic effect of high-dose GAA on I/R rats. Conclusion GAA has a good therapeutic effect on cerebral I/R injury in rats. GAA can reduce the apoptosis of nerve cells after cerebral I/R injury in rats, inhibit inflammation and oxidative stress responses, and alleviate brain injury. This effect may be related to the inhibition of the TLR4/NF-κB/NLRP3 signaling pathway.

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Development of a non-invasive risk classification diagnostic model for neuroblastoma based on microRNAs

LI Hengquan, ZHANG Mengxin, ZHANG Pin, ZHANG Fei, ZHANG Xianwei, ZHANG Wancun

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 23-29.

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Objective To establish a non-invasive risk classification diagnostic model for neuroblastoma (NB) by utilizing plasma-free microRNAs (miRNAs) as detection targets. Methods Based on transcriptomics technology, the abnormal expression of miRNAs between high-risk and medium-low-risk NB tissues was systematically screened. Key miRNAs for NB risk classification were further identified at the plasma level. Subsequently, a non-invasive risk classification diagnostic model was established using logistic regression analysis based on these key miRNAs. The diagnostic efficiency of the model was evaluated by analyzing the receiver operating characteristic (ROC) curve. Results A total of 19 miRNAs with abnormal expression in high-risk NB tissues were screened based on transcriptomics technology, and three key miRNAs for NB risk classification (miR-488-3p, miR-514a-3p, miR-887-3p) were further confirmed at the NB plasma level. Finally, based on logistic regression analysis, a non-invasive risk classification diagnostic model at the NB plasma level was established: Y=2.639-1.827×X1(miR-488-3p) + 1.201×X2(miR-514a-3p) - 1.484×X3(miR-887-3p). The sensitivity and specificity of this model for NB risk classification were 84.00% and 95.56%, respectively. Conclusion The model developed in this study is anticipated to offer a novel and effective strategy for NB risk classification.

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Explore the correlation between serum procollagen type Ⅲ N-terminal propeptide levels and senile sarcopenia

ZHAO Huan, YANG Wei

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 30-34.

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Objective To explore the relationship between serum procollagen type Ⅲ N-terminal propeptide (P3NP) and sarcopenia in the elderly, and to evaluate its predictive value. Methods A retrospective analysis was conducted on 130 elderly patients admitted to the Geriatric Department of Xuanwu Hospital, Capital Medical University from 2022 to 2024. According to the consensus of the Asian Working Group for Sarcopenia (AWGS), 36 cases of male sarcopenia, 29 cases of non-sarcopenia patients, 27 cases of female sarcopenia, and 38 cases of female non-sarcopenia were enrolled. Stratified by gender, the clinical characteristics and P3NP levels of the two groups were compared. Spearman correlation analysis was used to explore the correlation between P3NP and muscle strength and physical function. Multivariate Logistic regression analysis was used to analyze the risk factors of sarcopenia in the elderly. ROC curve was used to analyze the predictive efficacy of serum P3NP levels for sarcopenia in the elderly. Results The P3NP level in the sarcopenia group was significantly higher than that in the non-sarcopenia group (P<0.001). The P3NP level in female was significantly negatively correlated with grip strength, 6-meter walking speed, and the times of rises per 10 seconds (P<0.05). Multivariate Logistic regression analysis showed that P3NP (male OR=1.629, 95%CI: 1.243-2.133, P<0.001; female OR=1.391, 95%CI: 1.083-1.786, P=0.010) was an independent risk factor for sarcopenia. ROC curve showed that the area under the curve for predicting sarcopenia was 0.83(male) and 0.81(female). Conclusions The elevated P3NP level is associated with sarcopenia in the elderly, and it has good predictive value for sarcopenia. However, further research is still needed.

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Comparison of the efficacy of hydromorphone alone and sufentanil+butorphanol on analgesia after shoulder arthrolysis under general anesthesia

ZHU Jian, YU Jing, LU Jian, LIU Wei, ZHU Kaidi, CHEN Silou, YANG Jianfeng

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 35-39.

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Objective To investigate the analgesic efficacy differences between monotherapy with hydromorphone and combination therapy with sufentanil and buprenorphine after total shoulder manipulation under general anesthesia. Methods A total of 102 frozen shoulder patients requiring shoulder manipulation surgery admitted to our hospital from January 2022 to December 2024 were enrolled. Patients were divided into two groups based on postoperative analgesia. Methods Group A received pure hydromorphone intravenous pump analgesia, while Group B received sufentanil combined with buprenorphine intravenous pump analgesia. Pain levels were assessed using Visual Analog Scale (VAS), and shoulder function was evaluated with Constant-Murley scale. Stress response was measured through immunofluorescence assays for cortisol (Cor), norepinephrine (NE), and blood glucose (BG) levels. Adverse reactions during postoperative analgesia were recorded. Results (1) Group A showed lower VAS scores at 0.5, 12, 24, 48, and 72 h postoperatively compared to Group B; (2) Group A demonstrated higher Constant-Murley scores at 0.5, 12, 24, 48, and 72 h postoperatively than Group B; (3) Group A exhibited lower Cor, NE, and BG levels at 24, 48, and 72 h postoperatively compared to Group B; (4) No statistically significant difference in adverse reaction incidence was observed between Groups A and B during postoperative analgesia. Conclusion The analgesic effect of morphine alone after shoulder manual release under general anesthesia is better than the combination of sufentanil and buprotin, which can promote shoulder joint function recovery and has good safety, and has the value of promotion.

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Study on the correlation between gut microbiota changes and global developmental delay in premature infants via 16S rDNA sequencing

MIAO Dan, TAN Lin, ZHANG Mei, KUANG Xiaoni, CHEN Tao, ZHOU Dai, CHEN Xiangyu, MA Qi

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 40-47.

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Objective To investigate changes in the gut microbiota of preterm infants with Global Developmental Delay (GDD) using 16S rDNA high-throughput sequencing technology and explore the correlation between gut microbiota and GDD in preterm infants. Methods A total of 57 preterm infants with a gestational age of 32-36 weeks were enrolled, including 23 GDD infants (experimental group) and 34 non-GDD infants (control group). Fresh stool specimens were collected from all participants.16S rDNA sequencing was performed to analyze gut microbiota composition, followed by bioinformatics analysis to compare differences between the two groups. Results Differences were observed in the community structure, species abundance, and metabolic pathways of gut microbiota between the two groups. At the phylum level, Euryarchaeota was exclusively detected in the experimental group (0.023%, P<0.05). After corrected by False Discovery Rate (FDR), Q value was 0.42. Linear Discriminant Analysis Effect Size (LEfSe) revealed a higher abundance of the genus Dysgonomonas in GDD infants. Functional changes were identified in multiple pathways within MetaCyc modules, CAZY modules, GMM metabolic modules, and GBM neurotransmitter modules in the experimental group. Conclusion Compared to non-GDD preterm infants, GDD preterm infants exhibit gut microbiota dysbiosis, characterized by increased relative abundances of Euryarchaeota and Dysgonomonas, which may contribute to altered metabolic pathways and gut-brain axis function. However, currently, the alterations in gut microbiota of GDD preterm infants remain inconclusive, warranting further in-depth research.

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Analysis of differences in efficacy and prognostic factors of high-frequency ultrasound-guided PTA in the treatment of type IV forearm arteriovenous endovascular fistula stenosis

WANG Junyan, LIU Jiantong, SHI Jian, LI Yanling, LIU Mingyuan, HU Xiangdong

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 48-53.

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Objective To compare the patency outcomes of percutaneous transluminal angioplasty (PTA) in patients with forearm arteriovenous fistula (AVF) stenosis and investigate the efficacy of high-frequency ultrasound-guided PTA and prognostic factors influencing post-operative patency. Methods A total of 134 patients with forearm AVF stenosis treated at the Blood Purification Center of Beijing Nuclear Industry Hospital and Friendship Hospital of Capital Medical University from June 2022 to February 2024 were retrospectively analyzed. Patients were classified into four groups based on stenosis location: Type I (n=45, anastomotic stenosis), Type II (n=43, venous outflow stenosis), Type III (n=21, mixed stenosis), and Type IV (n=25, venous valve stenosis). All patients underwent ultrasound-guided PTA. Collect baseline patient data (age, gender, underlying diseases, etc. ) and pathway characteristics (anastomosis angle, puncture method, blood flow, etc. ), and use a multivariable Logistic regression model to analyze the independent risk factors affecting postoperative patency rates. Results Significant differences were observed in access usage duration among groups (Type I<Type II<Type III), with the shortest (1.48 years) in Type I and longest (6.65 years) in Type III. Post-PTA, residual stenosis diameter and brachial artery blood flow significantly improved in all groups. No intergroup differences in 1-, 3-, and 6-month patency rates were found, but 9-month patency rates differed significantly, with the most pronounced difference between Type II and Type IV. Multivariate Cox regression identified anastomotic angle<30°(OR=3.525, P<0.05), regional puncture (OR=2.151, P<0.05), blood flow>3 000 mL/min (OR=2.238, P<0.05), and diabetes mellitus (OR=2.808, P<0.05) as independent risk factors for Type I-IV stenosis, respectively. Conclusion High-frequency ultrasound-guided PTA effectively treats forearm AVF stenosis across all four types. Stenosis classification, anastomotic angle, puncture technique, and diabetes mellitus are critical determinants of post-operative patency.

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Dynamic effects of door-to-balloon time delay on revascularization efficacy and myocardial enzyme levels in patients with acute anterior myocardial infarction

TENG Chao, ZHANG Jieliang, MO Jiechao, XU Junguo

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 54-59.

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Objective To investigate the impact of door-to-balloon (D2B) time delay on revascularization efficacy and the dynamic changes of myocardial enzyme levels in patients with acute anterior myocardial infarction (AMI). Methods A retrospective analysis was conducted on 105 patients diagnosed with acute anterior wall myocardial infarction (AMI) who were admitted to our hospital and underwent percutaneous coronary intervention (PCI) between July 1, 2022, and June 30, 2024. Patients were evenly assigned to three groups (n=35 per group) based on the time from first medical contact to balloon inflation (door-to-balloon time, D2B): Group A (D2B ≤60 minutes), Group B (60 minutes <D2B≤120 minutes), and Group C (D2B>120 minutes). Post-treatment comparisons among the groups included clinical efficacy, success rate of coronary revascularization, time to symptom relief, and length of hospital stay. Serial measurements of myocardial enzyme levels—creatine kinase (CK) and creatine kinase isoenzyme-MB (CK-MB) —were performed at 6, 12, 24, and 72 hours after PCI to evaluate dynamic changes in myocardial injury. In addition, cardiac function was assessed using left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV), and left ventricular end-diastolic volume (LVEDV). The incidence of adverse cardiac events was also recorded and compared across the three groups. Results Group A demonstrated a significantly higher overall efficacy rate (94.29%) compared to Group B (77.14%) and Group C (71.43%). The success rate of revascularization in Group A (97.14%) was also significantly greater than in Groups B (82.86%) and C (77.14%). Time to symptom relief and hospital stay were notably shorter in Group A. Baseline CK and CK-MB levels showed no significant differences among the groups; however, at 6, 12, 24, and 72 hours post-treatment, levels in Group A were significantly lower than in the other groups. All groups showed improvement in LVEF after treatment, with the greatest increase observed in Group A. Additionally, reductions in LVEDV and LVESV were most pronounced in Group A. The incidence of adverse events in Group A was 2.86%, compared with 8.57% in Group B and 22.86% in Group C. The differences between groups were not statistically significant. Conclusion Shorter D2B time is associated with better clinical outcomes in patients with acute anterior AMI undergoing PCI. Prompt intervention significantly enhances revascularization success.

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Dose effect study of platelet rich plasma growth factor concentration gradient regulation on meniscus injury repair

CAO Yan, YANG Hongjun, GU Yong, TANG Heping, ZHOU Xueyu

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 60-65.

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Objective This study aims to clarify the dose-response relationship between the concentrations of growth factors (TGF-β, PDGF, IGF) in platelet-rich plasma (PRP) and the repair of meniscus injury. Methods 80 patients with acute meniscal injury were enrolled from 2021 to 2024. Among them, 60 patients were divided into low-, medium-, and high-bioactivity groups based on the composite Z-score of three growth factors (TGF-β, PDGF, IGF) (n=20 per group), while the remaining 20 patients served as the saline control group. Standard PRP prepared from a single donor was used (baseline concentration: TGF-β 18.5 ng/mL). The target concentration windows were achieved by gradient-adjusting with lyophilized human recombinant growth factor (TGF-β: HumanZyme HZ-1023) (low group: 12-15 ng/mL; medium group: 18-22 ng/mL; high group: 25-30 ng/mL). Measured concentration deviation after reconstitution was<5% for all batches. Efficacy was evaluated using the modified MRI Stoller score and Lysholm/IKDC functional scales pre- and post-intervention. Results The repair score of the high biological activity group was significantly better than that of the control group (24.5±2.3 vs 17.9±2.5, P<0.001); The comprehensive score was strongly positively correlated with functional improvement (r=0.79, P<0.001), and TGF-β had the highest contribution (regression β=0.62, 95% CI: 0.48-0.76); The ROC curve determines that a comprehensive score>1.2 (AUC=0.88) is the optimal treatment threshold, corresponding to an effective concentration window of growth factors TGF-β 23.5-28.7 ng/mL、PDGF 17.2-20.4 ng/mL、IGF 11.3-14.1 ng/mL. Conclusion The repair efficacy of PRP is concentration dependent, and precise regulation of freeze-dried PRP based on comprehensive scoring can optimize the therapeutic effect. When the concentration of TGF-β is greater than 23.5 ng/mL, the repair efficacy is significantly improved.

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Based on pelvic ultrasound before measuring chamber structure parameters prediction model is build maternal postpartum pelvic floor dysfunction

ZHANG Ying, SUN Lihua, WANG Yang, HONG Kehua, YIN Yanjuan, HE Huan

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 66-71.

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Objective To construct a prediction model of postpartum pelvic floor dysfunction (PFD) based on the anterior chamber structural parameters measured by pelvic floor ultrasound. Methods A total of 320 female patients who underwent ultrasound pelvic floor examination in our hospital from April 2021 to April 2024 were selected as the study objects, and were divided into normal group (n=206) and disabled group (n=114) according to their pelvic floor conditions. The general clinical data and anterior chamber structure parameters were statistically compared between the two groups. Multivariate logistic analysis was conducted to analyze the risk factors of postpartum PFD and to build a prediction model. Restricted cubic spline (RCS) model was used to analyze the dose-relationship between the structural parameters of the anterior chamber and postpartum PFD. Multivariate Logistic regression model was constructed and the predictive efficiency of the model was evaluated. Results The differences of age, gestational age, parity, adverse pregnancy rate, pelvic floor impact questionnaire-7 (PFIQ-7), pelvic floor distress inventory-short form 20 (PFDI-20) and pelvic organ prolapsed-urinary incontinence sexual questionnaire-12 (PISQ-12) scores between normal group and disorder group were statistically significant. There were significant differences in the levels of posterior vesicourethral angle (PUVA), edge of bladder neck to toe bone joint distance (D), detrusor thickness (BDT), urethral rotation angle (URA), bladder neck descent (BND), and urethral angle (UTA) between the normal group and the disorder group. Logistic regression analysis showed that high PUVA level, high D level, and high BDT level, URA, BND, UTA, higher age, higher gestational age, multiparity, history of adverse pregnancy and delivery, high level of PFIQ-7, high level of PFDI-20 and high level of PISQ-12 were risk factors for PFD. Based on the above general clinical data and anterior compartment structural parameters, the general clinical data model, anterior compartment structural parameter model and combined model were constructed. Model evaluation showed that the combined model could effectively predict the occurrence of postpartum pelvic floor dysfunction. Compared with the general clinical data model and the anterior compartment structural parameter model, the model showed better prediction performance. Conclusion In this study, based on the general clinical data and the anterior chamber structure parameters measured by pelvic floor ultrasound, a combined model for predicting postpartum PFD was constructed. This model has high predictive efficiency and has certain guiding significance for clinical practice.

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Randomized controlled study on the treatment of elderly patients with HFpEF using ω-3 polyunsaturated fatty acids

SU Jianpei, LIANG Bijuan, WU Qi, WANG Zhiming, ZHANG Yazhou, LI Jin, LI Rui, HE Miyu

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 72-77.

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Objective To investigate the therapeutic effect of ω-3 polyunsaturated fatty acids (ω3 PUFAs) in treating elderly patients with heart failure with preserved ejection fraction (HFpEF). Methods A total of 108 elderly patients with HFpEF from the Geriatrics Department of our hospital were selected from September 2022 to June 2023 and randomly divided into a control group (n=54) and an observation group (n=54) by a random number table method. The control group received routine heart failure treatment, while the observation group received treatment with ω3PUFAs on this basis. The clinical efficacy was observed between two groups, as well as the cardiac function [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT)], myocardial injury markers [high-sensitivity troponin T (hs-cTnT), high-sensitivity C-reactive protein (hs-CRP), amino terminal pro-brain natriuretic peptide (NT-proBNP)], inflammatory indicators [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), pentraxin 3 (PTX-3)], 6 min walking distance (6MWD), activities of daily living (ADL) before and after treatment. The incidence of major adverse cardiovascular events (MACE) in the two groups was also observed in two groups. Results The total effective rate of the observation group was higher than the control group. After 6 months of treatment, the LVEF of the observation group was higher than the control group, LVEDD and LVPWT were lower than the control group. After 6 months of treatment, the serum levels of hs-cTnT, hs-CRP, and NT-proBNP in the observation group were lower than those in the control group. After 6 months of treatment, the levels of serum IL-6, TNF-α, and PTX-3 in the observation group were lower than those in the control group. After 6 months of treatment, the 6MWD and ADL score of the observation group were higher than those of the control group. The incidence of MACE in the observation group was lower than the control group. Conclusion The efficacy of adding ω3PUFAs to conventional heart failure treatment for elderly patients with HFpEF is confirmed. It can improve cardiac function, reduce myocardial damage, inhibit inflammatory response, enhance exercise tolerance and activities of daily living, and decrease the incidence of MACE.

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Application of risk early warning and pre-control under the guidance of SWOT analysis in nursing of patients undergoing mechanical ventilation in ICU of neurosurgery department

WANG Lifeng, ZHOU Yu, LU Jingjing, DAI Xingliang

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 78-81.

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Objective To explore the application of risk early warning and pre-control under the guidance of strengths, weakness, opportunity, and threats (SWOT) analysis in the nursing of patients undergoing mechanical ventilation in Neurosurgical Intensive Care Unit (NICU). Methods A total of 80 patients undergoing mechanical ventilation in NICU of the hospital were enrolled between January 2021 and December 2024. According to envelope method, they were divided into risk early warning group (40 cases, risk early warning and pre-control under the guidance of SWOT analysis) and routine nursing group (40 cases, routine nursing). The stay time in NICU, mechanical ventilation time, total length of hospital stay, disease severity[multiple organ dysfunction syndrome (MODS), acute physiology and chronic health evaluation II (APACHE II)], mechanical ventilation effect[partial pressure of blood oxygen (PaO₂), partial pressure of carbon dioxide (PaCO₂), blood oxygen saturation (SaO₂) ]and incidence of complications were compared between the two groups. Results The stay time in NICU, mechanical ventilation time and total length of hospital stay in risk early warning group were shorter than those in routine nursing group (P<0.05), and scores of MODS and APACHE II were lower than those in routine nursing group (P<0.05). PaO₂ and SaO₂in risk early warning group were higher than those in routine nursing group, while PaCO₂ was lower than that in routine nursing group (P<0.05). The incidence of complications in risk early warning group was lower than that in routine nursing group (P<0.05). Conclusion Risk early warning and pre-control under the guidance of SWOT analysis can effectively shorten length of hospital stay, ensure mechanical ventilation effect, reduce incidence of complications and accelerate recovery of patients in NICU.

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Study on the diagnostic value of serum IL-27 combined with T-SPOT. TB in sputum negative pulmonary tuberculosis

FAN Ming, XIAO Yeqing, LIU Teng, DENG Gaoyan

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 82-87.

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Objective To investigate the diagnostic value of serum interleukin-27(IL-27) combined with T cell spot test of tuberculosis infection (T-SPOT.TB) in bacterial negative pulmonary tuberculosis. Methods The clinical data of 168 patients with pulmonary tuberculosis admitted to our hospital from April 2023 to July 2024 were retrospectively analyzed. they were divided into bacteria positive pulmonary tuberculosis group (n=84) and bacteria negative pulmonary tuberculosis group (n=84). In addition, 84 healthy subjects were selected as control group (n=84). The clinical data of the patients were collected. T-SPOT. TB, serum IL-27 and peripheral blood erythrocyte sedimentation rate (ESR) were detected in all patients. The differences of T-SPOT. TB, serum IL-27 and ESR among the three groups were compared, and the receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic efficacy of T-SPOT. TB, serum IL-27 alone and their combined detection for bacterial negative pulmonary tuberculosis. Results The positive rate of T-SPOT. TB in the tuberculosis group with positive bacteria and the tuberculosis group with negative bacteria was significantly higher than that in the control group. There was no significant difference in the positive rate of T-SPOT. TB detection between the positive pulmonary tuberculosis group and the negative pulmonary tuberculosis group. The serum IL-27 and peripheral blood ESR in the pulmonary tuberculosis group were higher than those in the control group. The serum IL-27 in the positive pulmonary tuberculosis group was higher than that in the negative pulmonary tuberculosis group. There was no significant difference in ESR between the positive pulmonary tuberculosis group and the negative pulmonary tuberculosis group. Taking the clinical comprehensive diagnosis as the reference standard, the efficacy of T-SPOT. TB, serum IL-27 alone and their combination in the diagnosis of pulmonary tuberculosis was as follows: the AUC of T-SPOT. TB diagnosis was 0.815, and the sensitivity and specificity were 84.52% (95% CI: 78.22-89.64) and 78.50% (95% CI: 68.28-86.81), respectively. The AUC of serum IL-27 was 0.848, the sensitivity and specificity were 65.48% (95% CI: 57.81-72.62) and 94.05% (95%CI: 86.74-98.03), respectively. The AUC of combined diagnosis was 0.936, the sensitivity and specificity were both 86.90% （95% CI: 80.80-91.63, 95% CI: 77.82-93.34). In the diagnosis of bacterial negative pulmonary tuberculosis, the diagnostic efficacy of serum IL-27 and T-SPOT. TB alone and in combination was as follows: the AUC of T-SPOT. TB diagnosis was 0.845, and the sensitivity and specificity were 82.14% (95% CI: 72.34-89.58) and 86.90% (95% CI: 77.82-93.34), respectively. The AUC of serum IL-27 was 0.867, the sensitivity and specificity were 91.67% (95% CI: 83.61-96.64) and 64.29% (95% CI: 53.13-74.42), respectively. The AUC of combined diagnosis was 0.955, and the sensitivity and specificity were 90.48% (95% CI: 82.12-95.84) and 86.90% (95% CI: 77.82-93.34), respectively. Conclusion Combined testing of both T-SPOT. TB and serum IL-27 would further improve the diagnostic efficacy in sputum-negative TB patients.

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Clinical value assessment of a nomogram model combining serum biomarkers and utrasound features for differentiating ovarian epithelial carcinoma

DENG Mei, LI Puqi, DING Linru, GUO Yiru

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 88-93.

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Objective To explore the risk factors of ovarian epithelial carcinoma, and to construct a nomogram based on clinical and ultrasonic characteristics to improve the preoperative evaluation value of ovarian tumors. Methods A retrospective analysis was performed on 482 patients with ovarian tumor who were treated in the Gynecology Department of Yuncheng Central Hospital Affiliated to Shanxi Medical University from January 2022 to September 2024, and they were divided into benign tumor group (n=350) and ovarian epithelial carcinoma group (n=132) according to pathological diagnosis. Patients were randomly divided into a training set (n=289) and a validation set (n=193) at a ratio of 6∶4. General clinical data and ultrasonic characteristic parameters of patients were collected. The risk factors of ovarian epithelial carcinoma were analyzed by univariate and multifactorial regression. R software was used to construct a nomogram to predict the occurrence of ovarian epithelial carcinoma, which was internally verified by validation sets. The results of model efficacy evaluation were characterized by ROC curve, calibration curve and DCA curve. Results There were statistically significant differences between the benign tumor group and the ovarian epithelial carcinoma group in age, menopause, pregnancy frequency, hypertension, diabetes, serum biochemical indexes, multilocular tumor, solid component, lesion location, maximum mass diameter and endometrial thickness (P<0.05). Multivariate Logistic regression analysis showed that age, maximum mass diameter, lesion location, presence or absence of solid components and serum marker CA153 were independent risk factors for ovarian epithelial carcinoma. The AUC of the nomogram model constructed based on the above indexes in the training set was 0.89(95%CI: 0.85-0.93), and the ACU in the validation set was 0.83(95%CI: 0.76-0.89), the calibration curve fits the ideal curve well, and the threshold probability corresponding to the net benefit interval of the DCA model is 0.05-0.95. Conclusion The nomogram model of ovarian epithelial carcinoma based on clinical and ultrasonic features has high predictive performance and good clinical application value, and can provide reference for preoperative identification of ovarian epithelial carcinoma.

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Analysis of the differential diagnostic value of MSCT-based computerised texture analysis combined with serum NSE, CYFRA21-1 and CEA indexes for the benign and malignant nature of isolated pulmonary nodules

JIN Wenjing, GAO Kaibo, ZHAO Hong, ZENG Min, ZHOU Qun, SUN Shuo

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 94-97.

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Objective To investigate the diagnostic value of multisliece helical CT (MSCT) based computer texture analysis combined with serum neuron-specific enolase (NSE), cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), and carcinoembryonic antigen (CEA) for distinguishing between benign and malignant solitary pulmonary nodules. Methods A total of 126 patients with solitary pulmonary nodules admitted to our hospital from January 2023 to December 2024 were selected and divided into lung cancer group (65 cases) and benign nodule group (61 cases) based on pathological diagnosis. The general data and imaging characteristics of both groups were compared. The correlation between computer texture parameters from MSCT and serum NSE, CYFRA21-1, and CEA was analyzed. ROC curves were used to evaluate the diagnostic value of computer texture features and serum tumor markers in distinguishing between benign and malignant solitary pulmonary nodules. Results Lung cancer patients showed higher proportions of partially solid nodules and spiculated margins compared to benign patients. Lung cancer patients exhibited higher entropy, entropy difference, entropy sum, and serum NSE, CYFRA21-1, and CEA levels than benign patients. Computer texture-related features showed positive correlations with serum NSE, CYFRA21-1, and CEA in lung cancer patients. ROC curve analysis revealed AUC values of 0.811, 0.710, 0.632, 0.618, and 0.951 for computer texture features, NSE, CYFRA21-1, CEA, and their combined applications respectively. Conclusion The combination of computer texture features and conventional serum tumor markers has a high power of differential diagnosis between benign and malignant pulmonary nodules, and has a good clinical application value.

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Clinical observation on sedative effects of Midazolam and Propofol combined with Remifentanil in elderly patients with severe cerebral hemorrhage undergoing mechanical ventilation

CHEN Lu, XU Yi, GUO Yan

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 98-102.

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Objective To observe the sedative effects of Midazolam combined with Remifentanil versus Propofol combined with Remifentanil in elderly patients with severe cerebral hemorrhage undergoing mechanical ventilation. Methods A total of 75 elderly patients with severe intracerebral hemorrhage who met the inclusion and exclusion criteria and were admitted to Longnan City First People's Hospital from January 2023 to February 2025 were collected. They were divided into an observation group (40 cases) and a control group (35 cases) based on the use of different sedative drugs. Both groups received Remifentanil for analgesia. On this basis, the control group patients received Midazolam for sedation, while the observation group received Propofol for sedation. The sedative effect, hemodynamic indicators, blood gas indicators at different time points after medication, the incidence of ventilator-associated pneumonia, and the incidence of adverse reactions between the two groups were compared and analyzed. Results There was no significant difference in the Behavioral Pain Scale (BPS) scores and Richmond Agitation-Sedation Scale (RASS) scores between the two groups at different time points (2, 8, 24, and 48 hours after medication). The heart rate of the observation group was lower than that of the control group at all time points. There was no significant difference in systolic blood pressure between the two groups at different time points, and no significant difference in diastolic blood pressure in the observation group at 24 and 48 hours; however, the diastolic blood pressure in the observation group at 2 and 8 hours was lower than that of the control group. There was no significant difference in the incidence of ventilator-associated pneumonia and vomiting between the two groups, but the incidence of bradycardia and hypotension was higher in the observation group than in the control group. Conclusion Both midazolam and propofol can meet the sedation requirements of elderly patients with severe cerebral hemorrhage undergoing mechanical ventilation. The midazolam group has little effect on blood gas indicators and hemodynamics, and the overall incidence of adverse events should not be low. It is an ideal sedation mode for elderly patients with severe cerebral hemorrhage undergoing mechanical ventilation.

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Comparison of clinical efficacy and safety between FOLEY catheter and dinoprostone suppository in promoting cervical ripening

HUANG Pingjie, LU Yan, JIA Xiaozhou, ZHU Yulian

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 103-106.

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Objective To analyze and to compare the efficacy and safety of FOLEY catheter and Dinoprostone suppository in promoting cervical ripening. Methods A total of 100 pregnant women admitted to our hospital from January 2024 to December 2024 were selected as the research subjects. They were randomly divided into a control group and an observation group, with 50 cases in each group. The control group was treated with Dinoprostone to promote cervical ripening, while the observation group received FOLEY catheter for the same purpose. The efficacy and safety of the two methods were analyzed and compared. Results There was no significant difference in cervical ripening between the control group and the observation group, all have ideal cervical ripening effects. Compared with the control group, the observation group showed no significant increase in the cesarean section rate, and there were no significant differences in neonatal Apgar scores or neonatal weight. Although the observation group had reductions in postpartum hemorrhage, adverse pregnancy outcomes such as fetal distress, neonatal asphyxia, and premature rupture of membranes, these differences were not statistically significant. However, the incidences of uterine hyperstimulation, meconium-stained amniotic fluid, abnormal fetal heart rate, and frequent uterine contractions in the observation group were significantly lower than those in the control group.

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The relationship between inflammation burden index and obliterans bronchiolitis after severe adenovirus infection in children

LUO Liyan, XU Chang, YANG Ting, MENG Yanni

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 107-110.

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Objective To explore the relationship between inflammation burden index (IBI) and bronchiolitis obliterans (BO) after severe adenovirus infection in children. Methods A total of 215 children with severe adenovirus infection without BO from April 2023 to March 2025 were selected as the non-BO group, and 82 children with severe adenovirus infection and BO during the same period were selected as the BO group. C-reactive protein (CRP), neutrophil count (NE), and lymphocyte count (LYM) were detected, and IBI was calculated (IBI=CRP×NE/LYM). The predictive value of CRP, NE, LYM, and IBI for BO in children with severe adenovirus infection was evaluated by the receiver operating characteristic (ROC) curve. The influencing factors of BO in children with severe adenovirus infection were explored by multivariate Logistic regression. Results CRP, NE, and IBI were higher in the BO group than in the non-BO group, while LYM was lower (P<0.05). The area under the curve (AUC) (95%CI) of CRP, NE, LYM, and IBI for predicting BO in children with severe adenovirus infection were 0.852(0.849-0.905), 0.761(0.718-0.814), 0.742(0.689-0.795), and 0.903(0.850-0.956), respectively. The cut-off values were 18.40 mg/L, 2.78×10⁹/L, 1.70×10⁹/L, and 31.58, respectively. The specificity was 67.11%, 58.27%, 56.35%, and 87.36%, respectively, and the sensitivity was 91.25%, 92.41%, 92.41%, and 84.19%, respectively. The age of the BO group was younger than that of the non-BO group, and the proportion of children with fever duration ≥5 days, hypoxemia, mechanical ventilation, and extrapulmonary complications was higher in the BO group than in the non-BO group. Multivariate analysis showed that long fever duration (OR=2.081, 95%CI: 1.483-2.921), mechanical ventilation (OR=2.342, 95%CI: 1.598-3.432), high CRP level (OR=3.524, 95%CI: 1.692-3.765), and high IBI (OR=3.025, 95%CI: 1.943-4.711) were risk factors for BO in children with severe adenovirus infection. Conclusion IBI is highly likely to be associated with the onset of BO in children with severe adenovirus infection, and has strong clinical accessibility. It is expected to serve as an important biomarker for predicting the occurrence of BO after severe adenovirus infection.

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Risk assessment of BI-RADS category 4 breast lesions based on imaging features

ZHANG Zhaoyang, ZHAO Ping, WU Liu, GAO Bo, ZHANG Jiao

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 111-118.

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Objective To develop a nomogram prediction model based on ultrasound and mammographic features for BI-RADS category 4 breast lesions and evaluate its diagnostic value in early differentiation of benign and malignant lesions. Methods A retrospective analysis was conducted on 113 pathologically confirmed BI-RADS 4 breast lesions (42 benign, 71 malignant). Ultrasound and mammographic features were extracted. Independent predictors were selected using LASSO regression and multivariate logistic regression to construct a nomogram model, which was evaluated in terms of discrimination (C-index), accuracy (AUC), sensitivity, and specificity. Additionally, three machine learning models—Extreme Gradient Boosting (XGBoost), Vision Transformer (ViT), and Graph Neural Network (GNN) —were implemented and compared using training and testing datasets. SHAP value analysis and attention mechanisms were employed to enhance model interpretability. Results Lesion margin, boundary, shape, edge, and density were identified as independent predictors. The nomogram model achieved a C-index of 0.779 and an AUC of 0.758. The XGBoost, ViT, and GNN models yielded AUCs of 0.881, 0.872, and 0.890, respectively, outperforming traditional regression. GNN achieved the best sensitivity (88.0%) and F1 score (0.857). Across all models, spiculated margins, irregular shape, and high density were key predictors of malignancy. Conclusion Deep learning models integrating multimodal features—especially GNN and ViT—can significantly improve the prediction accuracy of BI-RADS 4 breast lesion malignancy risk. These models hold great promise for clinical application and may assist in optimizing biopsy decision-making.

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Effects of Baiji Yulian Decoction as an adjunctive therapy for Helicobacter pylori positive gastric ulcers on gastrointestinal hormones and gastric mucosal morphology

LU Jinhua, LAN Yanhong, LI Xiaolan, LIANG Wangui, ZHONG Canxin

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 119-123.

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Objective To investigate the effect of the decoction on treating Helicobacter pylori (Hp) positive gastric ulcer and its effect on gastrointestinal hormones and gastric mucosa morphology. Methods This prospective study selected 72 patients with Hp-positive gastric ulcers of the Piwei damp-heat syndrome type who were treated at our hospital between October 2021 and September 2022. The patients were randomly divided into an experimental group and a control group, with 36 cases in each group. The control group received conventional quadruple therapy, while the experimental group received Baiji Yulian Decoction in addition to the quadruple therapy for 6 weeks. Efficacy was evaluated based on gastrointestinal hormone levels, gastric mucosal morphology, Hp eradication rate, and TCM symptom scores. Results Before treatment, gastrointestinal hormone levels, gastric mucosal morphology and traditional chinese medicine syndrome (TCM) points were compared between the two groups. After treatment, the GAS and VIP levels in the two groups were lower than before treatment, and the difference was statistically significant, the control group, the MTL level was higher than the patients before treatment, the difference was statistically significant, and the test group was higher than the control group, the difference was statistically significant. The gland density, mucosal thickness and degree of inflammatory cell infiltration were lower than those before treatment, and the difference was statistically significant, and the difference was lower in the test group than in the control group. Two groups of patients with epigastric burning pain, dry mouth and chest, acid reflux, irritability, constipation, new abdominal distension, acid reflux, nausea, stool, and tongue pulse of TCM syndrome points are lower than before treatment, difference has statistical significance, the test group is lower than the control group, difference have statistical difference. The eradication rate and total response rate of Helicobacter pylori in the test group were significantly higher than that in the control group, and the difference was significant. Conclusion The combination of white and quadruple therapy can significantly improve the Hp eradication rate of Hp positive gastric ulcer patients, improve gastric mucosa morphology, and regulate gastrointestinal hormone levels through multiple targets, with remarkable clinical efficacy.

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The effect of jaw-thrust maneuver combined with gentle chest compression with right elbow to prevent hypoxemia in painless fiberoptic bronchoscopy

ZHANG Qiling, ZHANG XiaoQing, LI Yufang, TAN Hongbao, WU Di

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 124-128.

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Objective To explore the effect of Jaw-thrust maneuver combined with gentle chest compression with right elbow to prevent hypoxemia in painless fiberoptic bronchoscopy. Methods 120 patients who underwent painless fiberoptic bronchoscopy were randomly divided into two groups, 60 patients in each group: group B (Jaw-thrust maneuver with both hands) and group BT (Jaw-thrust maneuver with both hands combined with gentle chest compression on the right elbow). After the patient's consciousness disappeared, the group B was given Jaw-thrust maneuver with both hands (mandibular angle moved forward by 0.5-1cm), and the group BT was received Jaw-thrust maneuver and gentle chest compression with the right elbow (the compression range is 2-3cm, the frequency is 30 times per min, a total of 20 times). The total time of searching and passing glottis, the incidence of the decline of blood oxygen (SpO₂<basic value), hypoxia state (SpO₂<95%) and hypoxemia (SpO₂<90%) in each group were compared. Besides, we collected the ventilation rate of face mask and diaphragm activity (DE) in each group. Results The incidence of the decline of blood oxygen, hypoxia state and hypoxemia in the group BT was significantly lower than that in B group. The diaphragmatic activity of 2 min after injection of the group BT was significantly increased compared with group B. Conclusion The method of Jaw-thrust maneuver combined with gentle chest compression with right elbow can reduce the occurrence of hypoxemia in painless fiberoptic bronchoscopy and enhance the movement of diaphragm under sedation. It is a simple, safe and effective method which is worth popularizing.

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A study on the synergistic effect of cesarean delivery and antenatal antibiotic use on the risk of allergic rhinitis in offspring

DONG Yunpeng, LIU Zixin, LI Jian

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 129-133.

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Objective To investigate the interaction between cesarean delivery and antenatal antibiotic use in the development of allergic rhinitis in children. Methods This study adopted a case-control research design, with a 1∶1 gender frequency matching principle. We enrolled 239 children diagnosed with allergic rhinitis as the case group and 239 children without a history of allergic rhinitis as the control group. Logistic regression analysis was applied to evaluate the association between cesarean delivery, antenatal antibiotic use, and the risk of allergic rhinitis in children. Both additive and multiplicative interaction models were analyzed. Results The cesarean delivery rate (50.7%) and antenatal antibiotic use rate (20.1%) in the case group were significantly higher than those in the control group (35.1% and 14.9%, respectively). Logistic regression analysis revealed that cesarean delivery (OR=1.917, 95% CI: 1.316-2.792, P<0.05) and antenatal antibiotic use (OR=2.369, 95% CI: 1.380-4.066, P<0.05) were independent risk factors for allergic rhinitis in children. Furthermore, the risk of allergic rhinitis in children born by cesarean delivery and exposed to antenatal antibiotics was 9.629 times higher than that in children not exposed to either factor. A significant multiplicative interaction was observed between cesarean delivery and antenatal antibiotic use (OR=4.359, 95% CI: 1.192-15.941, P=0.026). Conclusion Cesarean delivery and antenatal antibiotic use exhibit a synergistic effect on the development of allergic rhinitis in children. These findings suggest that reducing cesarean delivery rates and antenatal antibiotic use may be critical strategies for preventing allergic rhinitis in children.

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Clinical application of microvascular decompression surgery for hemifacial spasm assisted by 3d slicer virtual reality

HUANG Junping, HE Guojin, LIN Zhenli, LAN Xueting, NONG Qinhua, LAN Huan

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 134-138.

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Objective Explore the clinical efficacy of microvascular decompression (MVD) surgery assisted by 3D Slicer virtual reality technology in the treatment of hemifacial spasm (HFS). Methods Eighty-four patients with HFS (Hemifacial Spasm) from the Department of Neurosurgery at Guangxi Zhuang Autonomous Region Ethnic Hospital were selected as the research sample for this study, covering the period from July 2022 to April 2024. Based on the principle of the random number table method, they were divided into a control group (n=42, receiving conventional MVD treatment) and an observation group (n=42, undergoing MVD assisted by preoperative 3D Slicer three-dimensional reconstruction). The study compared the two groups in terms of pain intensity[Visual Analogue Scale (VAS) scores], quality of life[30-item Hemifacial Spasm Questionnaire (HFS-30) scores], clinical efficacy, postoperative complications, and recurrence rates. Results The VAS score of the observation group at 12 hours postoperatively was significantly lower than that of the control group (P<0.05). At 2 months post-surgery, the HFS-30 questionnaire score in the observation group was also lower than that in the control group (P<0.05). The overall therapeutic efficacy rate in the observation group reached 92.86%, which was significantly higher than the 71.43% observed in the control group. Additionally, the complication rate in the observation group was 4.76%, lower than the 19.05% in the control group (P<0.05). One-year follow-up results indicated that the recurrence rate in the observation group was 4.76% (2/42), which was lower than the 7.14% (3/42) in the control group. Conclusion MVD treatment for HFS assisted by 3D Slicer virtual reality technology demonstrates significant advantages, as it can enhance surgical efficacy, reduce complications, making it worthy of clinical promotion and application.

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Construction and verification of Nomogram prediction risk model for negative psychology in patients after breast cancer surgery

ZHANG Jie, ZHAO Yang, TANG Lanqin, AN Kunli, LU Biao

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 139-144.

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Objective To explore the influencing factors of negative psychology in patients with breast cancer after operation, to construct the Nomogram model, and to verify the predictive value of the model. Methods A total of 550 postoperative patients with breast cancer admitted to a tertiary hospital from January 2020 to December 2023 were selected as the research objects. Collect data such as general information, psychological evaluation results, pain score, marital status, per capita monthly income, medical treatment mode, whether radiotherapy and chemotherapy are needed, and disease stages. Logistic regression analysis was used to determine the influencing factors of negative psychology in postoperative patients with breast cancer, and R software was used to construct Nomogram model. Results Pain score (≥ 7 points) (OR=2.438, 95% CI: 1.324-4.490), per capita monthly income (<3000 yuan) (OR=3.334, 95% CI: 1.907-5.830), marital status of unmarried (OR=2.145, 95% CI: 1.122-4.101), and disease stage III (OR=2.863, 95% CI: 1.576-5.201) are all risk factors for negative psychology of patients with breast cancer after surgery. Conclusion Pain score, per capita monthly income, marital status and disease stage are significant influencing factors for negative psychology of breast cancer patients after surgery. The Nomogram model constructed based on these factors has good predictive value and can provide important reference for the formulation of personalized nursing strategies.

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The impact and significance of NT-proBNP levels on cardiac structure and function following arteriovenous fistula closure in renal transplant recipients

CHANG Shuai, YANG Jianping, ZHOU Hong, FAN Xiaoyu, XU Xiaoqin

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 145-151.

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Objective To investigate the effects of arteriovenous fistula (AVF) closure on cardiac structure and function, as well as changes in cardiac biomarkers, in renal transplant recipients. Methods A retrospective analysis of clinical data from 126 patients who underwent renal transplantation at the Nephrology Department of Xinjiang 474 Hospital between June 2021 and April 2024. The study included 66 patients in the AVF closure group and 60 patients in the AVF preservation group. All patients underwent baseline and follow-up ultrasonic cardiogram (UCG) imaging to assess cardiac structure and function. Serum creatinine (SCr), estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), and cardiac biomarkers N-terminal pro-B-type natriuretic peptide (NT-proBNP), cardiac troponin T (cTnT), and cardiac troponin I (cTnI) were measured. Pearson correlation and multiple linear regression analyses were performed to evaluate the associations between NT-proBNP, cTnT, cTnI, and cardiac structure and function post-AVF closure. Results Post-follow-up, in terms of cardiac structure, patients in the AVF closure group exhibited significant reductions in left ventricular (LV) mass, LV mass index, LV end-diastolic volume, LV end-systolic volume, left atrial (LA) volume, LA volume index, and right atrial (RA) area (P<0.05). For cardiac function, LV cardiac output, LV cardiac index, and pulmonary artery flow velocity were significantly reduced (P<0.05), while LV ejection fraction and blood pressure showed no significant changes (P>0.05). Cardiac biomarkers (NT-proBNP, cTnT, cTnI) were significantly reduced (P<0.05), whereas renal biomarkers (SCr, eGFR, BUN) showed no significant changes (P>0.05). Pearson correlation analysis revealed positive correlations between NT-proBNP, cTnT, cTnI, and changes in cardiac structure and function (P<0.05). Multiple linear regression showed that NT-proBNP was an independent correlate of changes in cardiac structure and function. Conclusion The reduction in NT-proBNP levels following AVF closure in renal transplant recipients is closely associated with improvements in cardiac structure and function, suggesting its potential value in the assessment of postoperative cardiac status.

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Diagnostic value of serum C-reactive protein, erythrocyte sedimentation rate and interleukin-6 on infection after open tibial fracture surgery

HE Dong, LANG Zhigang, YU Shan, LIN Daqiang

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 152-155.

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Objective To investigate the diagnostic value of serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and interleukin-6 (IL-6) on postoperative infection of open tibial fracture. Methods The clinical data of 98 patients with infection after open tibial fracture surgery in the hospital from April 2020 to April 2024 were retrospectively analyzed.98 patients without infection after open tibial fracture surgery were selected as the control group. The levels of serum CRP, ESR and IL-6 of the two groups of patients on the first day after the operation were detected. . Multivariate Logistic regression analysis was adopted to explore the related influencing factors of postoperative infection, and receiver operating characteristic (ROC) curve was applied to evaluate the efficiency of CRP, ESR and IL-6 in diagnosing postoperative infection of open tibial fracture. Results On the first day after the operation, the levels of CRP, ESR and IL-6 in the infection group were significantly higher than those in the control group (P<0.05). Logistic multivariate regression analysis showed that serum CRP (OR=1.089, 95%CI: 1.035-1.146), ESR (OR=1.063, 95%CI: 1.026-1.101), and IL-6 (OR=1.145, 95%CI: 1.069-1.226) was closely related to the occurrence of postoperative infection in patients with open tibial fractures (P<0.05) ROC curve analysis results showed that the AUCs of serum CRP, ESR and IL-6 in the diagnosis of infection after open tibial fracture surgery were 0.786, 0.813 and 0.784, the sensitivities were 0.806, 0.652 and 0.857, and the specificities were 0.643, 0.857 and 0.561 respectively (P<0.05). The AUC of combination of three serum indicators was 0.913, with sensitivity of 0.745 and specificity of 0.969 (P<0.05). Conclusion The combined detection of serum CRP, ESR and IL-6 can significantly improve the accuracy in the diagnosis of infection after open tibial fracture surgery.

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Application of percutaneous transhepatic gallbladder drainage combined with laparoscopic cholecystectomy sequential treatment in patients with delayed acute suppurative cholecystitis surgery

XIE Bowen, ZHONG Caihong, LIU Youyuan, WU Haoran, YIN Mingxiang

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 156-159.

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Objective To explore the application value of sequential treatment of percutaneous transhepatic gallbladder drainage (PTGBD) combined with laparoscopic cholecystectomy (LC) in patients with acute suppurative cholecystitis. Method 140 patients with acute suppurative cholecystitis who had onset time of more than 72 hours in Loudi Central Hospital and Changde Hospital affiliated to Xiangya Medical College of Central South University from January 2020 to January 2024 were collected as the research subjects. They were divided into the study group (70 cases in the sequential treatment group) and the control group (70 cases in the simple LC group) according to the different treatment plans received. The changes in various indicators and the incidence of complications during and after surgery were compared between the two groups. Results The average operation time, intraoperative blood loss, and total postoperative hospitalization time in the study group were all less than those in the control group. The first postoperative exhaust time and postoperative ambulation time in the study group were both earlier than those in the control group. The first laboratory scores of white blood cells, C-reactive protein, and serum IL-6 in the study group patients after surgery were statistically significant. The incidence of postoperative complications in the two groups of patients was as follows: 3 cases of hepatic insufficiency and 2 cases of fever in the study group, and 12 cases of hepatic insufficiency, 2 cases of postoperative biliary fistula, 1 case of bleeding, 10 cases of fever, 3 cases of conversion to open surgery, and 2 cases of biliary tract injury (1 case of right posterior lobe bile duct injury and 1 case of common hepatic duct injury) in the control group. There was a statistically significant difference in the overall incidence of complications. Conclusion PTGBD combined with LC sequential treatment can reduce the occurrence of complications, shorten the operation time, alleviate postoperative inflammatory reactions, and help patients recover quickly after surgery in patients with acute suppurative cholecystitis.

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Clinical efficacy evaluation of multidimensional intervention model for health literacy in patients with malignant tumors

PANG Yun, LIANG Wen, YU Xinwei

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 160-163.

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Objective To explore the role of multidimensional interventions for health literacy in alleviating psychological stress, improving treatment adherence, enhancing medical care experiences, and promoting doctor-patient communication among inpatients with malignant tumors. Methods From February 2022 to October 2022, 500 inpatients with malignant tumors were selected from Hunan Tumor Hospital. They were assessed using the Hamilton Depression Rating Scale (HAMD) and the Self-Rating Anxiety Scale (SAS). Among them, 209 patients had comorbid depressive mood, and 107 patients had comorbid anxiety mood. Depressed and anxious patients were randomly divided into an observation group and a control group separately. The control group received routine anti-cancer treatment, while the observation group received routine anti-cancer treatment plus a 3-month ‘health literacy’ intervention. This intervention involved an innovative knowledge service provided by a health literacy enhancement service team composed of multi-disciplinary experts, aimed at improving the patients’ health literacy. Evaluate the level of health knowledge needs among inpatients with tumors and compare the HAMD and SAS scale scores before and after intervention between the two groups of patients. Results 97% of patients have needs in terms of health literacy. After 3 months of health literacy intervention, the depression score of cancer patients with depressive mood was (22.12±1.35) points, significantly lower than before intervention (28.03±2.15); after 3 months of health literacy intervention, the anxiety score of cancer patients with anxiety was (52.31±2.15) points, significantly lower than before intervention (58.76±2.36). Through health literacy services, the health literacy knowledge of inpatients has significantly improved, their understanding of diseases has been enhanced, depressive and anxious emotions have improved, and their acceptance of clinical treatment has become higher. Conclusion Providing patients with electronic literature databases, conducting reading therapy, opening patient salons, and hosting health lectures can effectively improve the health literacy of hospitalized cancer patients in multiple dimensions, alleviate psychological stress, and improve symptoms of depression and anxiety.

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Therapeutic effect of Qingshen Guanchang Formula on patients with chronic kidney disease and the influence on renal function

LV Wei, LIU Shifu, LIU Wenjun

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 164-167.

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Objective To explore the therapeutic effect of Qingshen Guanchang Formula on patients with chronic kidney disease, and the influence on renal function. Methods A total of 94 patients with chronic kidney disease admitted to the hospital from January 2021 to September 2023 were reviewed. According to different treatment methods, the patients were assigned to the control group (n=46) and the observation group (n=48). The former received conventional symptomatic Western medicine treatment, and the latter was treated with Qingshen Guanchang Formula on the above basis. Therapeutic effects, serum creatinine (SCr) and blood urea nitrogen (BUN) levels, and adverse reactions were compared between the two groups. Results The response rate was 87.50% (42/48) in the observation group and 69.57% (32/46) in the control group, and the former was much higher. After treatment, the levels of SCr and BUN in the observation group were significantly lower than those before treatment. There was no significant difference in the levels of SCr and BUN between the two groups after treatment. The incidence rates of adverse reactions in the two groups were comparable. Conclusion Applying Qingshen Guanchang Formula to treat patients with chronic kidney disease can significantly improve the renal function of patients and has a low incidence of adverse reactions.

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Clinical transfusion safety research based on blood type system specific antibodies

DU Yingan, LIU Fengxia, CAO Xiaomei

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 168-171.

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Objective This study aims to analyze clinical data collected from patients with positive accidental antibody screening results, exploring the distribution of accidental antibodies and their correlation with transfusion history and pregnancy history, providing a reference basis for ensuring clinical transfusion safety. Methods This research collected clinical data from patients with positive and negative accidental antibody screening results at Xiangya Third Hospital of Central South University from April 2020 to March 2021, and conducted a retrospective analysis. Results Among the 116 patients, 66 cases of accidental antibody positivity were identified after excluding incomplete data, including 19 males and 47 females. Accidental antibodies were mainly distributed in the Rh system, with anti-E being the most common, accounting for 30.3%; the Lewis blood group system accounted for 18.18%, with some patients exhibiting both anti-Lea and anti-Le^b; in the MNS blood group system, anti-M accounted for 13.64% and anti-Mur antibodies accounted for 9.09%. Additionally, autoantibodies accounted for 3.03%, mixed antibodies accounted for 1.52%, and specific antibodies not detected accounted for 1.52%. Gender, transfusion history, and pregnancy history were statistically significant factors in the detection rate of accidental antibodies. Furthermore, multivariable logistic regression analysis indicated that a history of transfusion and pregnancy were independent risk factors for the production of accidental antibodies. Conclusion The detection rate of anti-E in the Rh blood group system is the highest, which requires attention. It is recommended to establish a Rh blood group system donor phenotype database to provide safer and faster transfusion treatment for patients.

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Detection of Mycobacterium tuberculosis Hsp16.3 by visual biosensor based on aptamers

XIANG Hui, LI Duo, ZHAO Wei, YUAN Shishan

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 172-177.

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Objective To construct two visual biosensors named as “competitive method” and “sandwich method” based on heat shock protein 16.3(Hsp16.3) aptamer and gold nanoclusters (AuNCs) for detection of Mycobacterium tuberculosis Hsp16.3 and provide reference for diagnosis of latent tuberculosis infection (LTBI). Methods Recombinant Hsp16.3 was induced to express in Escherichia coli BL21(DE3) containing recombinant expression plasmid pQE30-hsp16.3 and purified by metal chelate chromatography. AuNCs were prepared by glutathione reduction and coupled with the amino modified aptamer H66 and aptamer complementary strand H63 SL-2 M6. aptamer H63 SL-2 M6 was fixed on the microplate, and Hsp16.3 was used as the diagnostic antigen. The “competitive” biosensor was established by adding aptamer complementary chain H63 SL-2 M6 modified with AuNCs, and the “sandwich” biosensor was established by adding aptamer H66 modified with AuNCs. The reaction of trisodium citrate reduction method to prepare gold nanoparticles (AuNPs) was introduced as color development reaction. The color change in the preparation process of AuNPs caused by the concentration of hydrogen peroxide (H₂O₂) was used as the output signal. The absorbance value at 550 nm was measured by microplate detector, and the detection limit of the two biosensors was calculated to evaluate the detection performance. Results The conjugated AuNCs retained peroxidase-like activity. After reacting with Hsp16.3, the color reaction of the “competitive method” biosensor appears red; The color reaction of the sandwich biosensor is blue. The linear response range of the two visual biosensors was 100-700 ng/mL, and the detection limit for competition method and sandwich method was 87 ng/mL and 43 ng/mL respectively. Conclusion The two visual biosensors based on aptamers can effectively detect Hsp16.3.

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Study on the mechanism of joint vaccine participation in the immune response of mice infected with pneumococcus pneumoniae

LI Xin, LU Dong, LIU Dianqing, ZHANG Jing

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 178-182.

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Objective To investigate the effect of combined vaccine of Hemolytic streptococcus-Haemophilus influenzae type B-Streptococcus pneumoniae-Staphylococcus aureus-Pseudomonas aeruginosa-Klebsiella pneumoniae (SHSSPK) on the immune response of mice infected with diplococcus pneumoniae. Methods Forty-eight mice were randomly divided into four groups (12 mice per group): PBS group, SHSSSPK low dose group (SHSSSPK-L), SHSSSPK medium dose group (SHSSSPK-M), and SHSSSPK high dose groups (SHSSSPK-H). Different dose groups of SHSSSPK received oral SHSSSPK immunization once every two weeks, with doses of 0.1 mg/mL, 0.2 mg/mL and 0.4 mg/mL respectively. In PBS group, the same volume of PBS was taken orally. At the eighth week, six mice in each group were killed, and then spleen and serum samples were collected to detect serum antibodies and cytokines. The other six mice were infected with pneumococcus through respiratory tract to evaluate the humoral and cellular immune responses of mice. Results The levels of serum Ag-specific antibodies IgG and IgA in the SHSSPK-L, SHSSPK-M and SHSSPK-H groups gradually increased from week 2 and were significantly higher than those in the PBS group. The levels of antigen-specific proliferative responses and Th1-type cytokines IFN-γ and IL-2 in splenocytes were significantly increased in the SHSSPK different dose groups compared with the PBS group, as well as the number of S. pneumoniae colonies in lung homogenates and lung histopathology scores were significantly decreased. The levels of IFN-γ and TNF-α produced in the lungs were significantly lower in the different dose groups of SHSSPK compared with the PBS group, and this reduction was dose-dependent. Conclusions Immunization with SHSSPK induces humoral and cellular immune responses against S. pneumoniae, reduces bacterial burden and inhibits respiratory mycoplasma infection in mice.

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Effect of empathy intervention based on IKAP model on self-perceived burden and management ability of patients with coronary heart disease

LIU Yueting, FU Zhixia, MA Yujiao, YUAN Liang

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 183-187.

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Objective To analyze the effects of empathy intervention based on information-knowledge-belief-behavior (IKAP) model on self-perceived burden and management ability of patients with coronary heart disease (CHD). Methods 120 patients with CHD admitted to the cardiovascular Department of Jiangsu Provincial People's Hospital from June 2023 to May 2024 were divided into the routine intervention group (n=60) and the IKAP group (n=60) by random number table method. The conventional intervention group received the conventional intervention, the IKAP group received the empathy intervention based on the IKAP model on the basis of routine intervention, and both groups continued to intervene for 3 months. Treatment compliance, self-perceived burden after 3 months of intervention, self-management ability and quality of life before and after intervention, and satisfaction after 3 months of intervention were compared between the two groups. Results After 3 months of intervention, the treatment compliance of the IKAP group was better than that of the conventional intervention group. The self-perceived burden of the IKAP group was better than that of the conventional intervention group after 3 months of intervention. The scores of coronary heart disease self management behavior scale (CSMS) (daily life management, medical disease management, emotional management) and world health organization quality of life 100 (WHOQOL-100) (physical, psychological, independence, environment, social relations, spiritual support) of the two groups increased after 3 months of intervention, the IKAP group was higher. After 3 months of intervention, the total satisfaction rate between the conventional intervention group and the IKAP group, the IKAP group was higher (P<0.05). Conclusion Empathy intervention based on IKAP model could reduce the self-perceived burden of patients with coronary heart disease, improve the treatment compliance, self-management ability and quality of life of patients, and obtain the recognition of patients.

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Application of graded responsibility system holistic service in perioperative period of cesarean section women

WANG Shihong, WANG Fangfang, SHI Ruping, LI Xiaowei

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 188-192.

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Objective To explore the application value of graded responsibility system holistic service in the perioperative period of cesarean section women. Methods 82 puerperae with cesarean section in department of obstetrics of the hospital from January 2023 to January 2025 were prospectively selected as research subjects, and were randomly divided into observation group and control group by randomization ranking method, with 41 cases in each group. The control group received routine nursing, while the observation group was given graded responsibility system holistic service nursing. The postoperative rehabilitation indicators (first exhaust time, first ambulation time, hospital stay), breastfeeding status (success rate of breastfeeding) and occurrence of complications (incision infection, postpartum hemorrhage, lower extremity venous thrombosis) were recorded in the two groups. The pain degree[visual analogue scale (VAS) ]at 4, 8, 12 and 24 hours after delivery and psychological status[brief profile of mood states (bPOMS) ]before intervention and before discharge were compared. Results The first exhaust time and first ambulation time in observation group were significantly lower than those in the control group, and the success rate of breastfeeding was significantly higher than that in control group. At 24 hours after delivery, the SF-MPQ scores in observation group were significantly lower than those in control group. The scores of fatigue, depression, tension, anger and confusion of bPOMS in observation group before discharge were significantly lower than those in control group while the score of vitality dimension of bPOMS was significantly higher. There were no significant differences in the hospital stay and incidence of complications between groups. Conclusion Graded responsibility system holistic service nursing model can significantly improve the perinatal psychological status of cesarean section women, help to promote the success of breastfeeding, and accelerate the postoperative rehabilitation process.

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The application of multidisciplinary joint quality improvement nursing in reducing catheter obstruction or prolapse after PTCSL for intrahepatic bile duct stones

GUO Qingxin, CHEN Yumei, GUO Yun

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 193-197.

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Objective To explore the effects of multidisciplinary joint quality improvement nursing in reducing catheter obstruction or prolapse after percutaneous transhepatic choledochoscopic stone removal (PTCSL) and percutaneous transhepatic biliary drainage (PTCD) for intrahepatic bile duct stones. Methods A total of 80 patients with intrahepatic bile duct stones after PTCSL admitted to our hospital from March 2022 to March 2024 were included in the study and divided into the control group (n=40) and the observation group (n=40) by the random number table method. The control group received routine care, while the observation group adopted multidisciplinary joint quality improvement care based on the control group. Compare the frequency of patch replacement, hospital stay and the occurrence of catheter-related adverse events (such as catheter slippage and blockage) between the two groups; The visual analogue scale (VAS) scores, exercise of self-care ability scale (ESCA) scores, self-rating depression scale (SDS) and self-rating anxiety scale (SAS) scores before and after the intervention were compared between the two groups. Results The frequency of patch replacement and hospital stay in the observation group were both less than those in the control group and the differences were statistically significant. The VAS, ESCA, SDS and SAS scores of the two groups after intervention significantly improved compared with those before the intervention, and the improvement of the observation group was better than that of the control group. The incidences of catheter slippage and obstruction events in the observation group were significantly lower than in the control group. Conclusion Multidisciplinary joint quality improvement nursing has a significant effect on the nursing of patients after PTCSL for intrahepatic bile duct stones. It can significantly reduce the incidence of adverse events such as PTCD catheter obstruction or protrusion and promote the recovery of patients.

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Effects of nursing intervention based on IMB model and mind mapping on disease cognition and mood state of family members of children with epilepsy

MA Xiaoying, CHEN Hongyan, JIANG Fengqiong, CHEN Luping, FENG Zhijun, ZHANG Liwen, ZHANG Chunhua, WAN Li

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 198-203.

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Objective To explore the effects of nursing intervention based on information-motivation-behavioral skills (IMB) model combined with mind mapping on disease cognition and mood state of family members of children with epilepsy. Methods A total of 152 family members of children with epilepsy admitted to Mianyang Central Hospital from March 2024 to December 2024 were included for analysis and divided into the observation group (n=76) and the control group (n=76) according to the random number table method. The control group was given conventional nursing intervention, while the observation group received nursing intervention based on this combination of the IMB model and mind mapping. The scores of the self-rating depression and anxiety scale (SDS, SAS), epilepsy knowledge and attitude questionnaire, caregiver burden scale (CBI), and Herth hope scale (HHI) of the family members of the two groups of children before and after the intervention were compared; Compare the number of epileptic seizures and the number of traumas of the two groups of children before and after the intervention, as well as the satisfaction of the children's families with the medical staff. Results The SDS and SAS scores of the families of the two groups of children after the intervention were both lower than those before the intervention, and the scores of the observation group were lower than those of the control group. The scores of epilepsy knowledge and attitude questionnaires in both groups after the intervention were increased compared with those before the intervention, and the scores in the observation group were higher than those in the control group. The CBI scores of the family members of the two groups of children decreased after the intervention compared with those before the intervention, and the score of the observation group was lower than that of the control group. The HHI scores of both groups after the intervention were increased compared with those before the intervention, and the score of the observation group was higher than that of the control group. The number of epileptic seizures and the number of traumas in both groups of children after the intervention were lower than those before the intervention, and the observation group was lower than the control group. During the intervention period, the comparison of nursing satisfaction in the observation group was significantly higher than in the control group. Conclusion Compared with conventional health education, nursing intervention based on the combination of IMB model and mind mapping can significantly improve family members' cognition of the disease and improve negative emotions such as anxiety and depression, thus improving the quality of life of family members of children with epilepsy.

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The mediating effect of psychological capital between perceived social support and career decision-making difficultiesin medical college students

LIU Yixin, HUANG Tengjia, CAO Xi, CHEN Lei, QIN Lihua, LI Sheng

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 204-210.

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Objective To understand the current situation of medical students' career decision-making difficulties, and to explore the mediating role of psychological capital between medical students' perceived social support and career decision-making difficulties, so as to provide theoretical basis for preventing and intervening medical students' career decision-making difficulties. Methods From June to August 2024, 940 medical students from two medical colleges in Hunan Province and Shaanxi Province were selected as the research objects by convenience sampling method. The perceived social support scale, psychological capital scale and career decision-making difficulty scale were used for investigation. Results The total score of career decision-making difficulties of 940 medical students was (40.29±9.31), which was at a medium level. Career decision-making difficulties were negatively correlated with perceived social support (r=-0.473, P<0.01), and negatively correlated with psychological capital (r=-0.550, P<0.01). Psychological capital was positively correlated with perceived social support (r=0.606, P<0.01). Regression analysis showed that grade, major, internship or part-time experience, perceived social support and psychological capital were the influencing factors of career decision-making difficulties (P<0.05). Psychological capital played a partial mediating role between medical students' perceived social support and career decision-making difficulties. The mediating effect was -0.23, and the mediating effect accounts for 51.1% of the total effect. Conclusion Conclusion Medical colleges should actively take measures to improve the level of perceived social support of medical students, and pay attention to the cultivation and accumulation of psychological capital, which will be of great significance to improve the level of career decision-making and employment quality of medical students.

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Effect of traditional chinese medicine health care on treatment compliance and intelligence status of patients with mild to moderate vascular dementia

MIAO Xue, ZHANG Xiulan, SU Ling, HU Xiao

Journal of Hunan Normal University(Medical Science). 2025, 22(4): 211-216.

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Objective This study aimed to explore the impact of Traditional Chinese Medicine (TCM) therapies, based on the concept of Spirit Regulation, on the cognitive function of patients with vascular dementia. Methods Eighty patients with mild to moderate vascular dementia were recruited at our hospital between January 2024 and January 2025 and randomly assigned to either a treatment group or a control group, with 40 patients in each group. The control group received routine nursing care. The treatment group received routine care along with additional TCM therapies based on the principle of Spirit Regulation. These therapies included moxibustion, pestle needle therapy, and emotional care. Both groups were evaluated before and after the intervention in terms of TCM syndrome scores, cognitive function (assessed by the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment), daily living ability (measured by the Activities of Daily Living Scale (ADL) ), and blood lipid levels (including total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol). Results The experimental group showed improvement in cognitive function, daily living ability, and blood lipid-related indicators compared to baseline (P<0.05). After the intervention, the experimental group had higher cognitive function, daily living ability, and blood lipid-related indicators than the control group (P<0.05). Conclusion TCM nursing interventions based on Spirit Regulation effectively improve cognitive function and enhance the ability to perform daily activities in patients with mild to moderate vascular dementia.

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25 August 2025, Volume 22 Issue 4

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25 August 2025, Volume 22 Issue 4