Analysis of the Impact of Diabetes on Prostate Cancer Using Two-Sample Mendelian Randomization

WANG Jin; ZOU Zhi; LIU Bang; NING Shuancheng; CHEN Xiangyu

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Journal of Hunan Normal University(Medical Science) ›› 2024, Vol. 21 ›› Issue (5) : 24-30.

Clinical Medicine

Analysis of the Impact of Diabetes on Prostate Cancer Using Two-Sample Mendelian Randomization

WANG Jin, ZOU Zhi, LIU Bang, NING Shuancheng, CHEN Xiangyu

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Abstract

Objective This study aims to address the uncertainty regarding the causal relationship between diabetes mellitus (DM) and prostate cancer. By employing Mendelian randomization, we can eliminate potential confounding factors and clarify the causal link between DM and prostate cancer, which will aid in the prevention and treatment of these two diseases in clinical practice. Methods We utilized data from genome-wide association studies (GWAS) focused on type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and prostate cancer, all based on European populations. The T1DM dataset comprised 3, 428 patients with diabetes and 3, 428 healthy controls. The T2DM dataset included 148, 726 patients with diabetes and 965, 732 healthy controls. The prostate cancer dataset included 30, 945 patients with prostate disease and 368, 725 healthy individuals as controls. T2DM was used as the exposure variable, and we identified significantly associated and independent single nucleotide polymorphism (SNP) as instrumental variables. We employed a two-sample Mendelian randomization (2SMR) approach to evaluate the causal relationship between T1DM, T2DM, and prostate cancer. The analysis incorporated five methods: inverse variance weighting (IVW), Mendelian randomization regression (MR-Egger), weighted median, weighted mode, and simple mode, with IVW serving as the primary analytical method. Cochran's Q statistic was utilized to assess heterogeneity. Results The findings indicate that no causal effect was observed between T1DM and prostate cancer (IVW: OR=0.99; 95% CI: 0.99-1.001, P=0.18). In contrast, the presence of T2DM is associated with an increased incidence of prostate cancer in the overall population (IVW: OR=7.88, 95% CI: 6.95-8.93, P<0.05). Conclusion There is a causal relationship between T2DM and prostate cancer, and T2DM increases the risk of developing prostate cancer. However, no promotive relationship was found between T1DM and prostate cancer.

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Mendelian randomization / diabetes / prostate cancer

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WANG Jin, ZOU Zhi, LIU Bang, NING Shuancheng, CHEN Xiangyu. Analysis of the Impact of Diabetes on Prostate Cancer Using Two-Sample Mendelian Randomization[J]. Journal of Hunan Normal University(Medical Science). 2024, 21(5): 24-30

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