Effect of airway clearance technique on curative effect and serum CGRP and MMP-9 levels in patients with stroke-related pneumonia

CAO Xueping; XIONG Chencheng; ZHANG Wencai; LI Xiaofang

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Journal of Hunan Normal University(Medical Science) ›› 2024, Vol. 21 ›› Issue (5) : 55-59.

Effect of airway clearance technique on curative effect and serum CGRP and MMP-9 levels in patients with stroke-related pneumonia

CAO Xueping, XIONG Chencheng, ZHANG Wencai, LI Xiaofang

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Abstract

Objective To explore the effect of airway clearance technology on the curative effect and serum calcitoningene-relatedpeptide (CGRP) and matrix metalloprotein (MMP)-9 levels in patients with stroke related pneumonia. Methods 100 patients with stroke-related pneumonia treated in our hospital from June 2020 to December 2021 were selected as the research objects.100 patients were divided into experimental group and control group by random number table method, with 50 cases in each group. The patients in the control group were treated with routine treatment and intervention, and the patients in the experimental group were treated with airway clearance technology on the basis of the intervention measures in the control group. The curative effect, serum CGRP and MMP-9 levels were compared between the two groups. Results The effective treatment rate in the study group was 98.0%, which was significantly higher than that in the control group at 86.0%. Before the intervention, there were no significant differences between the two groups in terms of sputum expectoration, dyspnea scores, CPIS scores, CGRP levels, or MMP-9 levels. After the intervention, sputum expectoration scores, dyspnea scores, CPIS scores, and MMP-9 levels significantly decreased in both groups, while CGRP levels significantly increased. Additionally, the study group showed lower sputum expectoration scores, dyspnea scores, CPIS scores, and MMP-9 levels, and higher CGRP levels compared to the control group. Conclusion Airway clearance technology can significantly improve the curative effect of patients with stroke-related pneumonia, and significantly increase the level of serum CGRP and significantly decrease the level of MMP-9.

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airway clearance technology / stroke associated pneumonia / curative effect / calcitoningene-relatedpeptide / matrix metalloprotein-9

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CAO Xueping, XIONG Chencheng, ZHANG Wencai, LI Xiaofang. Effect of airway clearance technique on curative effect and serum CGRP and MMP-9 levels in patients with stroke-related pneumonia[J]. Journal of Hunan Normal University(Medical Science). 2024, 21(5): 55-59

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