目的：通过调查长沙市某高校女大学生对人类乳头状瘤病毒（human papilloma virus,HPV）及其疫苗的认知和接种现况,探讨女大学生认知水平及疫苗接种情况的相关影响因素,为进一步宣传和推广HPV疫苗接种提供科学依据。方法：本研究利用问卷星进行线上问卷调查,随机选取某高校大一、大二年级部分女大学生作为研究对象,进行横断面调查。通过统计学方法对数据作描述性分析,并利用χ²检验分析女大学生对HPV及其疫苗认知情况、用Logistic回归分析探讨影响女大学生认知水平相关因素及其疫苗接种相关影响因素。结果：524名女大学生被纳入分析,调查结果显示,女大学生宫颈癌的知晓率为96.0%,HPV的知晓率为87.2%,HPV疫苗的知晓率为91.8%,大学生对HPV及其疫苗的认知率为48.1%,即48.1%的大学生对HPV及其疫苗有较高的认知水平,51.9%的大学生认知水平较低。年级是大学生对HPV及其疫苗认知水平的影响因素,高年级学生比低年级学生的HPV认知率更高,年级（OR=3.086,95%CI:2.102~4.529）是影响大学生对HPV及其疫苗认知水平的因素。研究对象HPV疫苗的接种率较低,仅有17.6%的女大学生接种过HPV疫苗,8.4%的女大学生仅完成预约,74.0%的女大学生未接种且未预约HPV疫苗。而未接种疫苗的主要原因依次是预约困难（57.5%）、疫苗价格昂贵（41.8%）以及未深入了解HPV疫苗（30.7%）。月消费水平（OR=2.022,95%CI:1.292~3.164）、父亲文化程度（OR=1.382,95%CI:1.036~1.842）、户籍（OR=1.827,95%CI:1.098~3.038）是女大学生接种HPV疫苗的影响因素。结论：大学生对HPV及其疫苗的认知率不高,女大学生疫苗接种率较低,建议加强对HPV及其疫苗相关的健康宣传与知识教育,进一步提高大学生对HPV及其疫苗的认知水平,提高大学生HPV接种率。

Objective To investigate the awareness and current situation of HPV and HPV vaccination among female college students in a university in Changsha, to explore the factors influencing the awareness level and vaccination status of female college students, and to provide scientific basis for further promotion of HPV vaccination. Methods An online questionnaire survey was conducted using Wenjuanxing, and some female university students from the first and second years of a certain university were randomly selected as the study subjects for a cross-sectional survey. Descriptive statistical analysis was performed on the data, and the chi-square test was used to analyze the female university students' awareness of HPV and its vaccine. Logistic regression analysis was utilized to explore the factors influencing their awareness level and vaccination status. Results A total of 524 female university students were included in the analysis. The survey results showed that the awareness rate of cervical cancer among female university students was 96.0%, the awareness rate of HPV was 87.2%, and the awareness rate of HPV vaccine was 91.8%. The overall awareness rate of HPV and its vaccine among university students was 48.1%, indicating that 48.1% of university students had a high level of awareness of HPV and its vaccine, while 51.9% had a lower level of awareness. Grade was a factor influencing university students' awareness level of HPV and its vaccine, with higher-grade students having a higher awareness rate of HPV than lower-grade students. Grade(OR=3.086, 95%CI: 2.102-4.529) was a factor affecting university students' awareness level of HPV and its vaccine. The vaccination rate of HPV vaccine among the study subjects was relatively low, with only 17.6% of female university students having received the HPV vaccine, 8.4% having only made an appointment, and 74.0% neither vaccinated nor having made an appointment for the HPV vaccine. The main reasons for not being vaccinated were difficulty in making an appointment (57.5%), high vaccine price (41.8%), and lack of in-depth understanding of the HPV vaccine (30.7%). Monthly consumption level (OR=2.022, 95%CI: 1.292-3.164), father's education level (OR=1.382, 95%CI: 1.036-1.842), and household registration (OR=1.827, 95%CI: 1.098-3.038) were factors influencing female university students' vaccination against HPV. Conclusion The awareness rate of HPV and its vaccine among university students is not high, and the vaccination rate among female university students is relatively low. It is recommended to strengthen health promotion and education related to HPV and its vaccine, further improving university students' awareness level of HPV and its vaccine and increasing the HPV vaccination rate among university students.