目的：探讨人工真皮移植联合自体刃厚皮移植在大面积软组织缺损修复中的应用及并发症。方法：选择于2020年5月至2023年12月期间我院收治的86例大面积软组织缺损患者,利用分层随机化分组法,随机将其分为观察组（43例）和对照组（43例）。对照组使用自体刃厚皮移植进行治疗,观察组在对照组的基础上采用人工真皮移植联合进行治疗。观察两组成活率、愈合时间、瘢痕程度[温哥华瘢痕评定量表（Vancouver scar scale,VSS）]及术后并发症情况。结果：观察组大面积软组织缺损患者术后1周的成活率显著高于对照组;观察组供区愈合时间低于对照组,受区愈合时间高于对照组;在术后6个月时,观察组和对照组大面积软组织缺损患者供区和受区VSS评分均降低,且观察组供区VSS评分低于对照组,受区VSS评分高于对照组,差异有统计学意义;在术后1周时,观察组供区及受区VSS评分与对照组相比,差异无统计学意义,两组患者术后并发症发生情况差异不显著。结论：人工真皮移植联合自体刃厚皮移植可以提高大面积软组织缺损患者的修复成功率,促进供区创面愈合,且愈合后瘢痕程度轻,安全性较高。

Objective To explore the application and complications of artificial dermis transplantation combined with autologous blade thick skin graft in the repair of large soft tissue defects. Methods 86 patients with large-area soft tissue defects admitted from May 2020 to December 2023 were selected. Using stratified randomization grouping method, they were randomly divided into an observation group （43 cases） and a control group （43 cases）. The control group was treated with autologous split-thickness skin transplantation, and the observation group was treated with artificial dermis transplantation combined on the basis of the control group. The survival rate, healing time, scar degree [Vancouver Scar Scale (VSS)] and postoperative complications of the two groups were observed. Results The survival rate of patients with large-area soft tissue defects in the observation group was significantly higher than that in the control group one week after surgery; the healing time of the donor site in the observation group was lower than that in the control group, and the healing time of the recipient site was higher than that in the control group; at 6 months after surgery, the VSS scores of the donor and recipient sites of patients with large-area soft tissue defects in the observation group and the control group were both reduced, and the VSS score of the donor site in the observation group was lower than that in the control group, and the VSS score of the recipient site was higher than that in the control group, with statistically significant differences; at one week after surgery, there was no statistically significant difference in the VSS scores of the donor and recipient sites between the observation group and the control group, and there was no significant difference in the occurrence of postoperative complications between the two groups. Conclusion Artificial dermis transplantation combined with autologous split-thickness skin transplantation can improve the repair success rate of patients with large-area soft tissue defects, promote the healing of donor site wounds, and the degree of scar after healing is light and the safety is high.