目的: 探讨多组分运动训练对老年肺结核衰弱患者炎症因子及氧化应激的影响。方法: 采用便利抽样法选取2021年4月―10月长沙市某肺科医院的老年结核病患者,随机分为实验组（n=34）和对照组（n=32）,对照组予以常规结核病管理,饮食宣教、运动指导,实验组在常规结核病管理的基础上采用12周多组分运动管理方案。收集患者基线资料,比较干预前后两组患者衰弱状态、血清炎症因子、氧化应激因子水平。结果: 干预12周后实验组体质量指数高于干预前,高于对照组,衰弱评分均低于干预前,低于对照组,血清IL-6、TNF-α、CRP、SOD表达水平均低于干预前,低于对照组。结论: 多组分运动训练可有效降低炎症因子水平和减少氧化应激,从而改善老年结核患者衰弱状态。
Abstract
Objective The aim of this study was to evaluate the effect of multicomponent exercise program on inflammatory factors and oxidative stress in frail elderly patients with pulmonary tuberculosis. Methods 66 frail elderly patients with pulmonary tuberculosis in Chest Center of Changsha hospital from April to October 2021 were selected by use of convenience sampling method, they were randomly divided into the intervention group (n=34) and the control group (n=32). In the control group, the routine care including tuberculosis care, nutritional guidance and exercise guidance was provided. In the intervention group, 12 weeks of multicomponent exercise in addition to routine care was provided. This study collected the baseline characteristics and compared the blood inflammatory biomarkers including interleukins 6(IL-6) and tumor necrosis factor-α (TNF- α) and C-reactive protein (CRP) and the superoxide dismutase (SOD) levels, frailty state Results After the intervention, the BMI of the intervention group was higher than that before and the control group, the weakness score was lower than that before and the control group, and the expression levels of serum IL-6, TNF-α, CRP and SOD were lower than that before and the control group. Conclusion Multicomponent exercise can effectively improve the elderly pulmonary tuberculosis patients’ frailty state, reduce expression of proinflammatory cytokines and superoxide dismutase levels.
关键词
肺结核 /
衰弱 /
多组分运动 /
炎症 /
氧化应激
Key words
tuberculosis /
frailty /
multicomponent exercise /
inflammation /
oxidative stress
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基金
长沙市自然科学基金资助项目“多组分运动联合个性化营养在老年肺结核衰弱患者中的应用研究”（kq2014027）
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