目的: 本研究旨在评估艾拉莫德联合硫酸羟氯喹片治疗原发性干燥综合征（primary Sjögren's syndrome,PSS）的临床疗效。方法: 回顾性选取2019年1月—2023年1月安徽铜陵市立医院收治的80例PSS患者,按治疗方法不同分为对照组（37例）和联合组（43例）,对照组接受艾拉莫德治疗,联合组接受艾拉莫德联合硫酸羟氯喹片治疗。观察两组患者临床疗效、唾液流率、泪液分泌、干燥综合征患者报告指数（EULAR Sjögren's syndrome patient reported index,ESSPRI）、干燥综合征疾病活动指数（EULAR Sjögren's syndrome disease activity index,ESSDAI）、红细胞沉降率（erythrocyte sedimentation rate,ESR）、C反应蛋白（C-reactive protein,CRP）和免疫球蛋白G（immunoglobulin G,IgG）,同时,监测两组的不良反应发生情况。结果: 治疗后,联合组的治疗总有效率高于对照组;联合组唾液流率、泪液分泌、ESSPRI、ESSDAI评分均优于对照组;联合组患者的ESR、CRP和IgG水平低于对照组;两组患者的不良反应发生率,差异无统计学意义。结论: 艾拉莫德联合硫酸羟氯喹片治疗原发性干燥综合征患者能显著改善唾液和泪液分泌,降低炎症指标,且安全性良好,为PSS的治疗提供了一种有效的组合疗法。
Abstract
Objective This study aimed to evaluate the clinical efficacy of Apremilast combined with Hydroxychloroquine in treating Primary Sjögren's Syndrome (PSS). Methods A retrospective study was conducted on 80 patients with primary Sjögren's Syndrome (PSS) treated at the Tongling City Hospital in Anhui Province from January 2019 to January 2023. Patients were divided into a combination therapy group (43 cases) who received treatment with Alramod combined with Hydroxychloroquine Sulfate tablets, and a control group (37 cases) who received Alramod alone. Clinical efficacy, salivary flow rate, tear secretion, Patient Reported Index in Sjögren's Syndrome (EULAR Sjögren's Syndrome Patient Reported Index, ESSPRI), Sjögren's Syndrome Disease Activity Index (EULAR Sjögren's Syndrome Disease Activity Index, ESSDAI), as well as levels of Erythrocyte Sedimentation Rate (ESR), C-reactive Protein (CRP), and Immunoglobulin G (IgG) were observed in both groups. Additionally, the incidence of adverse reactions in both groups was monitored. Results After treatment, the total effective rate of the combination group was higher than that of the control group; the saliva flow rate, tear secretion, ESSPRI, and ESSDAI scores of the combination group were better than those of the control group; the levels of ESR, CRP, and IgG in patients of the combination group were lower than those in the control group; there was no statistically significant difference in the incidence of adverse reactions between the two groups. Conclusion The combination of Elamod and Hydroxychloroquine Sulfate Tablets in the treatment of patients with primary Sjogren's Syndrome can significantly improve saliva and tear secretion, reduce inflammatory indicators, and has good safety, providing an effective combination therapy for the treatment of PSS.
关键词
原发性干燥综合征 /
艾拉莫德 /
硫酸羟氯喹片 /
唾液流率 /
免疫水平 /
炎症因子 /
不良反应
Key words
primary Sjögren's syndrome /
apremilast /
hydroxychloroquine /
salivary flow rate /
immune level /
inflammatory factors /
adverse reactions
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基金
安徽省自然科学基金项目“托法替布治疗类风湿性关节炎的疗效与安全性研究”（2208085MH267）
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