目的：研究软肝降脂胶囊对急性冠脉综合征患者血管内皮功能及血小板功能的影响。方法：收集如皋市中医院2021年7月—2022年7月收治的120例急性冠脉综合征患者,分为二级预防组（60例）和联合中药组（60例）。二级预防组采用冠心病二级预防药物治疗,联合中药组在二级预防组的基础上采用软肝降脂胶囊治疗。比较两组中医证候积分、心功能、血清血管内皮功能指标水平、血清炎性因子、脂代谢指标水平、血小板功能指标及阿司匹林抵抗、氯吡格雷抵抗情况,统计两组安全性。结果：治疗6个月后与治疗前比较,两组中医症候积分、心功能及血清血管内皮功能水平均明显改善,联合中药组改善程度优于二级预防组。治疗前及治疗1、6个月后,两组血清炎性因子水平及血小板功能指标均明显改善,联合中药组治疗1、6个月后改善程度优于二级预防组。治疗前及治疗1、3、6个月后,两组血清脂代谢指标水平均明显改善,联合中药组治疗1、3、6个月后改善程度优于二级预防组。治疗6个月后,两组阿司匹林抵抗率、氯吡格雷抵抗率较治疗1个月后均升高,但联合中药组治疗1、6个月后低于二级预防组。结论：软肝降脂胶囊可改善急性冠脉综合征患者中医证候、心功能、血管内皮功能、血小板功能,降低机体炎症反应,促进脂代谢,降低阿司匹林抵抗、氯吡格雷抵抗发生的风险,同时不会增加不良反应的发生,具有较好的治疗效果。

Objective To study the effect of Ruangan Jiangzhi capsule on vascular endothelial function and platelet function in patients with acute coronary syndrome. Methods A total of 120 patients with acute coronary syndrome admitted to Rugao Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Chinese Medicine from July 2021 to July 2022 were divided into the secondary prevention treatment group (60 cases) and combined the combined the Chinese medicine group (60 cases) by random number table method. The secondary prevention and treatment group was treated with standard secondary prevention drugs for coronary heart disease, and the combined Chinese medicine group was treated with Ruganjiangzhi capsule on the basis of the secondary prevention and treatment group, and both groups were treated for 6 months. The traditional Chinese medicine symptom score, cardiac function, serum vascular endothelial function index level, serum inflammatory factors, lipid metabolism index level, platelet function index, aspirin resistance and clopidogrel resistance were compared between the two groups, and the safety of the two groups was counted. Results After 6 months of treatment, compared with before treatment, the score of traditional Chinese medicine symptom, cardiac function and level of serum vascular endothelial function of the two groups were significantly improved, and the improvement degree of the combined Chinese medicine group was better than that of the secondary prevention treatment group . Before treatment and after 1 and 6 months of treatment, the levels of serum inflammatory factors and platelet function indexes in the two groups were significantly improved, and the improvement degree in the combined Chinese medicine group was better than that in the secondary prevention treatment group after 1 and 6 months of treatment . Before treatment and after 1, 3 and 6 months of treatment, the serum lipid metabolism indexes of the two groups were obviously improved, and the improvement degree of the combined Chinese medicine group after 1, 3 and 6 months of treatment was better than that of the secondary prevention treatment group . After 6 months of treatment, the aspirin resistance rate and clopidogrel resistance rate of the two groups increased compared with 1 month of treatment, and the combined Chinese medicine group was lower than the secondary prevention treatment group after 1 and 6 months of treatment . Conclusion Ruangan Jiangzhi Capsule could improve traditional Chinese medicine syndrome, cardiac function, vascular endothelial function and platelet function of patients with acute coronary syndrome, reduce the risk of inflammatory reaction, aspirin resistance and clopidogrel resistance, promote lipid metabolism, and at the same time, it would not increase the occurrence of adverse reactions, with good therapeutic effect.