牛奶摄入与儿童过敏性鼻炎发病相关性的meta分析

洪兰; 杨珊伊; 眭维恕; 袁驰与; 袁华兵; 尹美龙; 胡裕章

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湖南师范大学学报医学版 ›› 2023, Vol. 20 ›› Issue (1) : 92-96.

临床医学

牛奶摄入与儿童过敏性鼻炎发病相关性的meta分析

洪兰¹, 杨珊伊², 眭维恕³, 袁驰与³, 袁华兵¹, 尹美龙², 胡裕章²

作者信息 +

Meta-analysis of the relationship between milk intake and the incidence of children with allergic rhinitis

HONG Lan¹, YANG Shanyi², SUI Weishu³, YUAN Chiyu³, YUAN Huabing¹, YIN Meilong², HU Yuzhang²

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文章历史 +

摘要

目的: 探讨牛奶对过敏性鼻炎（AR）发病率的影响。方法: 在PubMed、Embase和 Cochrane Library数据库经过检索式检索,筛取2001-2019年牛奶与AR关系的英文文献,筛选文献并对最终文献进行质量评分和数据提取,应用Stata 12.0统计软件进行荟萃分析。结果: 最终共纳入 12个研究,165966例患者。摄入牛奶与AR有关（RR=1.05,95％ CI：1.01~1.09）,亚组结果显示亚洲儿童服用牛奶（RR=1.24,95% CI：1.04~1.44）与大于七岁的儿童（RR=1.25,95% CI：1.05~1.46）可以增加AR的发病率。Begg's（P=0.950）以及Egger's（P=0.782）说明相关研究未显示发表偏倚。结论: 摄入牛奶与AR发病率增加有关,但还需要进一步的研究进行证明。

Abstract

Objective This study aims to investigate the effect of milk on the incidence of allergic rhinitis (AR). Methods English literature on the relationship between milk and AR from 2001 to 2019 was selected in PubMed, Embase and Cochrane Library. Literature was screened and quality score and data extraction were performed on the final literature. Stata 12.0 statistical software was used for meta-analysis. Results A total of 12 studies and 165, 966 patients were included. Milk intake was associated with AR (RR=1.05, 95% CI: 1.01-1.09), and subgroup results showed that milk intake increased the incidence of AR in Asian children (RR=1.24, 95% CI: 1.04-1.4 4) and in children older than seven years (RR=1.25, 95% CI: 1.05-1.46). Begg's (P=0.950) and Egger's (P=0.782) indicated that the relevant studies did not show publication bias. Conclusion The results of this study suggest that intake of milk is associated with an increased incidence of AR, but further studies are needed to confirm this.

导出引用

洪兰, 杨珊伊, 眭维恕, 袁驰与, 袁华兵, 尹美龙, 胡裕章. 牛奶摄入与儿童过敏性鼻炎发病相关性的meta分析[J]. 湖南师范大学学报医学版. 2023, 20(1): 92-96

HONG Lan, YANG Shanyi, SUI Weishu, YUAN Chiyu, YUAN Huabing, YIN Meilong, HU Yuzhang. Meta-analysis of the relationship between milk intake and the incidence of children with allergic rhinitis[J]. Journal of Hunan Normal University(Medical Science). 2023, 20(1): 92-96

中图分类号： R765.21

参考文献

[1] Luthra M, Bist SS, Mishra S, et al.Evaluation of Association of Allergic Rhinitis with Bronchial Asthma[J]. Indian J Otolaryngol Head Neck Surg, 2019, 71(Suppl 3): 1687-1691.
[2] Brozek JL, Bousquet J, Agache I, et al.Allergic rhinitis and its impact on asthma (aria) guidelines-2016 revision[J]. J Allergy Clin Immunol, 2017, 140(4): 950-958.
[3] Tsabouri S, Ntritsos G, Koskeridis F, et al.Omalizumab for the treatment of allergic rhinitis: a systematic review and meta-analysis[J]. Rhinology, 2021, 59(6): 501-510.
[4] Bousquet J, Khaltaev N, Cruz AA, et al. Allergic rhinitis and its impact on asthma (aria) 2008 update
(in collaboration with the world health organization, ga (2) len and allergen[J]. Allergy, 2008, 63(Suppl 86): 8-160.
[5] Pau BC, Ng DK.Prevalence of otitis media with effusion in children with allergic rhinitis, a cross sectional study[J]. Int J Pediatr Otorhinolaryngol, 2016, 84: 156-160.
[6] Saulyte J, Regueira C, Montes-Martinez A, et al.Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: A systematic review and meta-analysis[J]. PLoS Med, 2014, 11(3): e1001611.
[7] Qi S, Barnig C, Charles AL, et al.Effect of nasal allergen challenge in allergic rhinitis on mitochondrial function of peripheral blood mononuclear cells[J]. Ann Allergy Asthma Immunol, 2017, 118(3): 367-369.
[8] Badorrek P, Muller M, Koch W, et al.Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure[J]. Ann Allergy Asthma lmmunol, 2017, 118(3): 290-297.
[9] Ellis AK, Tenn MW.Advances in rhinitis: Models and mechanisms[J]. Ann Allergy Asthma Immunol, 2018, 121(1): 61-64.
[10] Li JY, Zhang Y, Lin XP, et al.Association between DNA hypomethylation at il13 gene and allergic rhinitis in house dust mite-sensitized subjects[J]. Clin Exp Allergy, 2016, 46(2): 298-307.
[11] Greenland S.Quantitative methods in the review of epidemiologic literature[J]. Epidemiol Rev, 1987, 9: 1-30.
[12] von Berg A, Filipiak-Pittroff B, Schulz H, et al. Allergic manifestation 15 years after early intervention with hydrolyzed formulas--the gini study[J]. Allergy, 2016, 71(2): 210-219.
[13] Bedolla-Barajas M, Morales-Romero J, Gaxiola-Arredondo BY, et al.Prolonged breastfeeding and delayed introduction of whole cow's milk into the diet are factors associated with egg sensitization: A matched case-control study[J]. Allergol Immunopathol (Madr), 2018, 46(6): 539-545.
[14] Bertelsen RJ, Brantsaeter AL, Magnus MC, et al.Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases[J]. J Allergy Clin Immunol, 2014, 133(1): 165-171.
[15] Christiansen ES, Kjaer HF, Eller E, et al.Early-life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14 years of age[J]. Pediatr Allergy lmmunol, 2017, 28(8).776-783.
[16] Kusunoki T, Morimoto T, Nishikomori R, et al.Allergic status of schoolchildren with food allergy to eggs, milk or wheat in infancy[J]. Pediatr Allergy Immunol, 2009, 20(7): 642-7.
[17] Loo EX, Llanora GV, Lu Q, et al.Supplementation with probiotics in the first 6 months of life did not protect against eczema and allergy in at-risk asian infants: A 5-year follow-up[J]. Int Arch Allergy Immunol, 2014, 163(1): 25-28.
[18] Maslova E, Halldorsson TI, Strom M, et al.Low-fat yoghurt intake in pregnancy associated with increased child asthma and allergic rhinitis risk: A prospective cohort study[J]. J Nutr Sci, 2012, 1: e5.
[19] Perkin MR, Bader T, Rudnicka AR, et al.Inter-relationship between rhinitis and conjunctivitis in allergic rhinoconjunctivitis and associated risk factors in rural uk children[J]. PloS one, 2015, 10(11): e0143651.
[20] Strinnholm A, Winberg A, West C, et al.Food hypersensitivity is common in swedish schoolchildren, especially oral reactions to fruit and gastrointestinal reactions to milk[J]. Acta Paediatr, 2014, 103(12): 1290-1296.
[21] Wickens K, Lane JM, Fitzharris P, et al.Farm residence and exposures and the risk of allergic diseases in new zealand children[J]. Allergy, 2002, 57(12): 1171-1179.
[22] Winberg A, Strinnholm Å, Hedman L, et al.High incidence and remission of reported food hypersensitivity in swedish children followed from 8 to 12 years of age-a population based cohort study[J]. Clin Transl Allergy, 2014, 4: 32.
[23] Hill DA, Grundmeier RW, Ram G, et al.The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children: A retrospective cohort study[J]. BMC Pediatr, 2016, 16: 133.
[24] Fiocchi A, Brozek J, Schunemann H, et al.World allergy organization (wao) diagnosis and rationale for action against cow's milk allergy (dracma) guidelines[J]. Pediatr Allergy Immunol, 2010, 21(Suppl 21): 1-125.
[25] Soumelis V, Reche PA, Kanzler H, et al.Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP[J]. Nat Immunol, 2002, 3(7): 673-680.
[26] Ruinemans-Koerts J, Schmidt-Hieltjes Y, Jansen A, et al.The Basophil Activation Test reduces the need for a food challenge test in children suspected of IgE-mediated cow's milk allergy[J]. Clin Exp Allergy, 2019, 49(3): 350-356.
[27] Creticos P, Peters S, Adkinson N, et al.Peptide leukotriene release after antigen challenge in patients sensitive to ragweed[J]. N Engl J Med, 1984, 310(25): 1626-1630.
[28] Peters-Golden M, Gleason MM, Togias A.Cysteinyl leukotrienes: multifunctional mediators in allergic rhinitis[J]. Clin Exp Allergy, 2006, 36(6): 689-703.
[29] Choi GS, Park HJ, Hur GY, et al.Vascular endothelial growth factor in allergen-induced nasal inflammation[J]. Clin Exp Allergy, 2009, 39(5): 655-661.