目的: 观察异维A酸联合臭氧水疗方法对寻常型痤疮患者的临床疗效。方法: 回顾性分析112例寻常型痤疮患者,分为观察组56例和对照组56例。对照组患者行异维A酸胶囊口服干预,观察组在异维A酸胶囊基础上,进行臭氧水疗干预,观察两组患者的临床效果。结果: 观察组患者总有效率为92.86%,明显高于对照组的73.21%。观察组患者白头粉刺、黑头粉刺、皮脂溢出、丘疹、脓疱消退率明显高于对照组。两组患者不良反应发生率无明显差异。结论: 异维A酸联合臭氧水疗能明显提高对寻常型痤疮的疗效,促进皮损的消退,适合临床广泛实施。
Abstract
Objective To observe the clinical effect of isotretinoic acid combined with ozone hydrotherapy on acne vulgaris. Methods 112 patients with acne vulgaris were retrospectively analyzed and divided into observation group (56 cases) and control group (56 cases). The patients in the control group received oral intervention with isotretinoic acid capsules, while the patients in the observation group received ozone hydrotherapy intervention on the basis of isotretinoic acid capsules, and the clinical effects of the two groups were observed. Results The total effective rate of patients in the observation group was 92.86%, significantly higher than 73.21% in the control group. The regression rate of white head acne, black head acne, sebum overflow, papules and pustules in the observation group was significantly higher than that in the control group. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Isoretinoic acid combined with ozone hydrotherapy can significantly improve the efficacy of acne vulgaris and promote the regression of skin lesions, which is suitable for clinical application.
关键词
寻常型痤疮 /
异维A酸 /
臭氧水疗
Key words
acne vulgaris /
isotretinoin capsules /
ozone hydrotherapy
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] 王雪松, 许芳, 石学波. CO2点阵激光联合羟基乙酸治疗面部炎性痤疮疗效观察[J]. 中国美容医学, 2020, 29(12): 23-26.
[2] Moosa AS, Quah JHM, How CH.Primary care approach to managing acne[J]. Singapore Med J, 2021, 62(11): 568-573.
[3] Habeshian KA, Cohen BA.Current Issues in the Treatment of Acne Vulgaris[J]. Pediatrics, 2020, 145(Suppl 2): S225-S230.
[4] 赵辨. 中国临床皮肤病学[M]. 南京: 江苏凤凰科学技术出版社, 2017: 1288-1289.
[5] 夏卉, 赵莉. 口服异维A酸联合光动力治疗重度痤疮疗效分析[J]. 中国美容医学, 2021, 30(5): 86-89.
[6] Han XD, Oon HH, Goh CL.Epidemiology of post‐adolescence acne and adolescence acne in Singapore: a 10-year retrospective and comparative study[J]. J Eur Acad Dermatol Venereol, 2016, 30(10): 1790-1793.
[7] Clark AK, Haas KN, Sivamani RK.Edible Plants and Their Influence on the Gut Microbiome and Acne[J]. Int J Mol Sci, 2017, 18(5): 1070.
[8] Smith RN, Mann NJ, Braue A, et al.The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: A randomized, investigator-masked, controlled trial[J]. J Am Acad Dermatol, 2007, 57(2): 247-256.
[9] Thiboutot DM, Dréno B, Abanmi A, et al. Practical management of acne for clinicians: an international consensus from the Global Alliance to Improve Outcomes in Acne[J]. Am Acad Dermatol, 2018, 78(2 Suppl 1): S1-S23. e1.
[10] 齐艳宁. 臭氧水疗治疗小儿特应性皮炎的疗效观察[J]. 中国中西医结合皮肤性病学杂志, 2021, 20(1): 53-55.
[11] 张英博, 鲁建云, 向亚平, 等. 联合臭氧水治疗特应性皮炎患者的疗效及白细胞介素4, 神经生长因子检测[J]. 中华皮肤科杂志, 2016, 49(10): 736-738.
[12] 秦桂芝, 黄进华, 潘伊枝, 等. 臭氧制剂外用创新性治疗婴幼儿特应性皮炎[J]. 中南大学学报 (医学版), 2018, 43(2): 163-167.
[13] 范亚云, 郭书萍. 医用臭氧在皮肤科疾病治疗中的应用进展[J]. 中国现代医药杂志, 2018, 20(2): 102-105.
[14] 何春峰, 王辉军, 索相旭, 等. 臭氧水疗联合红光以及甲硝唑凝胶治疗玫瑰痤疮的临床疗效和安全性研究[J]. 中国激光医学杂志, 2018, 27(6): 389-393+422.