Enterprise支架联合弹簧圈栓塞用于颅内宽颈动脉瘤介入治疗患者临床效果观察

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摘要 目的: 观察Enterprise支架联合弹簧圈栓塞用于颅内宽颈动脉瘤（wide-necked aneurysms,IWA）介入治疗的临床效果。方法: 对2021年9月―2023年6月本院收治的IWA患者资料进行回顾性分析,根据使用支架不同,分为LVIS组（LVIS支架联合弹簧圈栓塞）和Enterprise组（Enterprise支架联合弹簧圈栓塞）,应用倾向性评分匹配法（卡钳值设置为0.01,以1∶1匹配两组）,最终两组各获得54例基线资料均衡可比的患者。比较两组动脉瘤栓塞效果（术后即刻、术后6个月）、术后并发症（动脉瘤再出血、血管痉挛、支架内血栓形成）、预后情况[Rankin量表（mRs）]、生活质量（SF-36评分）。结果: 术后6个月,LVIS组、Enterprise组栓塞效果与术后即刻比较,差异无统计学意义,术后即刻、术后6个月组间栓塞效果比较,无统计学意义;两组并发症比较差异无统计学意义;出院时,两组预后情况比较,差异无统计学意义,术后6个月,LVIS组、Enterprise组预后情况与出院时比较,均优于出院时预后情况,但术后6个月组间预后情况比较差异无统计学意义;术后6个月,LVIS组、Enterprise组SF-36评分与术前SF-36评分比较,均升高,且术前、术后6个月差值组间比较,无统计学意义。结论: Enterprise支架联合弹簧圈栓塞与LVIS支架联合弹簧圈栓塞IWA效果相当,均能有效改善患者生活质量。

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	张隆辉
	陈敏
	查正江
	罗斌
	程少文
	施正生

关键词 ：颅内宽颈动脉瘤, Enterprise支架, LVIS支架, 弹簧圈栓塞

Abstract：Objective To observe the clinical effect of Enterprise stent combined with coil embolization in the interventional treatment of intracranial wide-necked aneurysms (IWA). Methods The data of patients with IWA admitted to our hospital from September 2021 to June 2023 were retrospectively analyzed. According to the use of stents, they were divided into LVIS group (LVIS stent combined with coil embolization) and Enterprise group (Enterprise stent combined with coil embolization). The propensity score matching method (the caliper value was set to 0.01, and the two groups were matched by 1: 1. Finally, 54 patients with balanced baseline data were obtained in each group. The effect of aneurysm embolization (immediately after operation, 6 months after operation, postoperative complications (aneurysm rebleeding, vasospasm, stent thrombosis), prognosis [modified Rankin scale (mRs) ], quality of life (SF-36) were compared between the both groups. Results At 6 months after surgery, the embolization effect in LVIS group and Enterprise group revealed that there was no statistical difference by rank sum test compared with that immediately after surgery. Rank sum test showed no statistical significance in the embolization effect between groups immediately after surgery and at 6 months after surgery. There were no statistical differences in complications between groups. At discharge, chi-square test revealed no statistical significance in the prognosis between both groups. At 6 months after surgery, the prognosis in LVIS group and Enterprise group was better than that at discharge by chi-square test, but no statistical difference was shown in prognosis between groups at 6 months after surgery. At 6 months after surgery, SF-36 score in LVIS group and Enterprise group was risen compared to before surgery by paired t test, and the difference before surgery and at 6 months after surgery between groups showed no statistical difference by t test. Conclusion The effect of Enterprise stent combined with coil embolization and LVIS stent combined with coil embolization IWA is equivalent, which can significantly advance quality of life of patients, but the short-term effect of Enterprise stent assisted treatment is not as good as LVIS stent.

Key words： intracranial wide-necked aneurysms enterprise stent lVIS stent coil embolization

收稿日期: 2024-04-27

中图分类号:

R543.4

基金资助:安徽高校自然科学研究项目“LncRNA PVT1调控VSMC表型转化在颅内动脉瘤发生及破裂中的作用及机制研究”（2022AH052554）

通讯作者: 张隆辉,E-mail：15110233371@163.com

引用本文:

张隆辉, 陈敏, 查正江, 罗斌, 程少文, 施正生. Enterprise支架联合弹簧圈栓塞用于颅内宽颈动脉瘤介入治疗患者临床效果观察[J]. 湖南师范大学学报(医学版), 2024, 21(3): 59-62. ZHANG Longhui, CHEN Min, ZHA Zhengjiang, LUO Bin, CHENG Shaowen, SHI Zhengsheng. Clinical effect of Enterprise stent combined with coil embolization in the interventional treatment of intracranial wide-necked aneurysms. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(3): 59-62.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2024/V21/I3/59

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