Hif-1α/Vegf信号通路活化对基底节出血患者病情的影响

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (2635 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 目的: 探讨缺氧诱导因子1α（hypoxia-inducible factor 1α,HIF-1α）/血管内皮生长因子（vascular endothelial growth factor ,VEGF）表达与脑基底节出血病情及预后的关系。方法: 选择2019年1月至2022年1月106名脑基底节出血患者为研究对象。使用用双抗夹心酶联免疫测量血清HIF-1α、VEGF的水平。通过多变量逻辑回归分析血清HIF-1α、VEGF水平与早期神经功能恶化（early neurologic deterioration,END）以及损伤后3个月不良预后之间的关系,并通过受试者工作特征曲线评估变量的预测能力。结果: 患者入院时血清HIF-1α、VEGF水平与入院NIHSS评分呈显著正相关（r=0.6267、0.8495,均P<0.001）。随着基线血肿大小的增加,入院血清HIF-1α、VEGF水平在急性脑出血（intracerebral hemorrhage,ICH）后显著升高（r=0.5352、0.6418,均P<0.001）。血清HIF-1α水平（OR=4.054,95%CI：1.368~12.009,P=0.012）和血清VEGF水平（OR=1.821,95%CI：1.119~2.965,P=0.016）是急性ICH后END的独立预测因子。血清HIF-1α水平（OR=4.721,95%CI：1.662~13.407,P=0.014）和血清VEGF水平（OR=2.198,95%CI：1.204~4.013,P=0.010）是急性ICH后预后较差的独立预测因子。血清HIF-1α水平预测急性脑出血患者END（AUC=0.7465,95%CI：0.6572~0.8178,P<0.001）和3个月预后（AUC=0.7744,95%CI：0.7072~0.8416,P<0.001）的能力高于血清VEGF水平（AUC=0.6882,95%CI：0.6113~0.7650,P<0.001;AUC=0.7025,95%CI：0.6270~0.7780,P<0.001）。结论: 血清HIF-1α和VEGF水平与ICH后3个月的END和不良预后独立相关,血清HIF-1α水平的预后价值高于血清VEGF。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	赵敏
	杨宇莹
	高晓霞
	李吉明

关键词 ：缺氧诱导因子1α, 血管内皮生长因子, 基底节出血, 病情, 预后

Abstract：Objective To investigate the relationship between the expression of hypoxia-inducible factor 1α (HIF-1α) /vascular endothelial growth factor (VEGF) and the condition and prognosis of basal ganglia hemorrhage. Methods A total of 106 patients with basal ganglia hemorrhage from January 2019 to January 2022 were selected as the research subjects. The concentrations of serum HIF-1α and VEGF were measured by sandwich enzyme-linked immunosorbent assay with double antibodies. The associations between serum HIF-1α and VEGF concentrations and early neurological deterioration and poor prognosis 3 months after injury were analyzed by multivariate logistic regression, and the predictive power of the variables was assessed by receiver operating characteristic curve. Results The serum HIF-1α and VEGF concentrations at admission were significantly positively correlated with the admission NIHSS score (r=0.6267, 0.8495, both P<0.001). With the increase of baseline hematoma size, the serum HIF-1α and VEGF concentrations were significantly increased after acute ICH (r=0.5352, 0.6418, both P<0.001). Serum HIF-1α concentration (OR=4.054, 95%CI: 1.368-12.009; P=0.012) and serum VEGF concentration (OR=1.821, 95%CI: 1.119-2.965; P=0.016) were independent of END after acute ICH predictor. Serum HIF-1α concentration (OR=4.721, 95%CI: 1.662-13.407; P=0.014) and serum VEGF concentration (OR=2.198, 95%CI: 1.204-4.013, P=0.010) were associated with worse prognosis after acute ICH independent predictors. Serum HIF-1α concentration predicted early neurological deterioration (AUC=0.746, 95%CI: 0.6572-0.8178, P<0.001) and 3-month prognosis (AUC=0.7744, 95%CI: 0.7072-0.8416; P<0.001) was better than the serum VEGF concentrations (AUC=0.6882, 95%CI: 0.6113-0.7650; P<0.001 and AUC=0.7025, 95%CI: 0.6270-0.7780; P<0.001). Conclusion Serum HIF-1α and VEGF concentrations are independently associated with END and poor prognosis 3 months after ICH. In addition, the prognostic value of serum HIF-1α concentration is better than that of serum VEGF.

Key words： hypoxia-inducible factor 1α vascular endothelial growth factor basal ganglia hemorrhage condition prognosis

收稿日期: 2023-10-27

中图分类号:

R743.34

基金资助:新疆维吾尔自治区卫生健康委员会科研基金项目“Hif-1α/Vegf信号通路活化对基底节出血患者病情的影响”（20210271）

通讯作者: 李吉明,E-mail：260774208@qq.com

引用本文:

赵敏, 杨宇莹, 高晓霞, 李吉明. Hif-1α/Vegf信号通路活化对基底节出血患者病情的影响[J]. 湖南师范大学学报(医学版), 2024, 21(2): 45-50. ZHAO Min, YANG Yuying, GAO Xiaoxia, LI Jiming. Effect of Hif-1α/Vegf signal pathway activation on the condition of patients with basal ganglia hemorrhage. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(2): 45-50.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2024/V21/I2/45

[1] 陈燕, 张秋, 尤年兴, 等. 急性缺血性脑卒中静脉溶栓后神经功能恢复及脑出血转化发生的影响因素分析[J]. 中华危重病急救医学, 2020, 32(11) : 1340-1345.
[2] 郭永涛, 李明超, 安坤, 等. 脑白质疏松对幕上自发性脑出血预后及血肿扩大的影响[J]. 中华神经医学杂志, 2020, 19(8) : 780-786.
[3] 郑海军, 戴凯茜, 娄晓辉, 等. 缺氧诱导因子-1α/血管内皮生长因子通路表达与高血压脑出血破入脑室患者颅内压及预后的相关性[J]. 中华高血压杂志, 2022, 30(3) : 283-286.
[4] 晋明璐, 陶陶, 邹哲华, 等. 重组腺病毒缺氧诱导因子-1α体外靶向性转染大鼠缺氧脑微血管内皮细胞的研究[J]. 中华老年医学杂志, 2020, 39(5) : 587-590.
[5] YU W, JIN H, SUN W, et al.Connexin43 promotes angiogenesis through activating the HIF-1α/VEGF signaling pathway under chronic cerebral hypoperfusion[J]. J Cereb Blood Flow Metab, 2021, 41(10) : 2656-2675.
[6] SHIM J W, MADSEN J R.VEGF signaling in neurological disorders[J]. Int J Mol Sci, 2018, 19(1) : 275.
[7] BERNSTEIN J E, SAVLA P, DONG F, et al.Inflammatory markers and severity of intracerebral hemorrhage[J]. Cureus, 2018, 13(1) : e12605.
[8] WANG C L, XU Y W, YAN X J, et al.Usability of serum annexin A7 as a biochemical marker of poor outcome and early neurological deterioration after acute primary intracerebral hemorrhage: A prospective cohort study[J]. Front Neurol, 2022, 13: 954631.
[9] RADU R A, TERECOASA E O, TIU C, et al.Clinical Characteristics and Outcomes of Patients with Intracerebral Hemorrhage-A Feasibility Study on Romanian Patients[J]. J Med Life, 2020, 13(2) : 125-131.
[10] 毕胜, 盛宝英, 韩凤, 等. 缺氧诱导因子1α参与大脑中动脉闭塞模型大鼠的脑损伤与脑保护[J]. 中国组织工程研究, 2021, 25(35) : 5644-5649.
[11] 何秀慧. 缺氧诱导因子1α与核因子κB在炎症缺氧环境中相互作用研究进展[J]. 国际生物制品学杂志, 2020, 12(1) : 41-45.
[12] SHEN Y, GU J, LIU Z, et al.Inhibition of HIF-1α reduced blood brain barrier damage by regulating MMP-2 and VEGF during acute cerebral ischemia[J]. Front Cell Neurosci, 2018, 12: 288.
[13] PARK H, CHOI S H, KONG M J, et al.Dysfunction of 67-kDa laminin receptor disrupts BBB integrity via impaired dystrophin/AQP4 complex and p38 MAPK/VEGF activation following status epilepticus[J]. Front Cell Neurosci, 2019, 13: 236.
[14] YANG X, ZHANG Y, GENG K, et al.Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1α/VEGF Signaling and Blood-Brain Barrier Integrity[J]. Cell Mol Neurobiol, 2021, 41(6) : 1203-1215.
[15] LI J, LI C, YUAN W, et al.Targeted temperature management suppresses hypoxia-inducible factor-1α and vascular endothelial growth factor expression in a pig model of cardiac arrest[J]. Neurocritical Care, 2021, 35(2) : 379-388.
[16] 岑丽霞, 靳敏, 袁汝康. 急性脑出血患者血清HIF-1α与VEGF、Hsp70动态表达情况研究[J]. 临床与病理杂志, 2016, 36(8) : 1177-1181.