黄斑区格栅样光凝联合雷珠单抗对糖尿病性黄斑水肿患者血清VEGF和IL-6水平影响

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摘要 目的: 探究黄斑区格栅样光凝与雷珠单抗联合对糖尿病性黄斑水肿（DME）患者血清血管内皮生长因子（VEGF）和白介素-6（IL-6）水平影响,以期为二者联合治疗DME及其可能作用机制提供参考。方法: 选择2021年1月―2023年1月成都三六三医院收治的DME患者98例,采用随机数字表法将患者单盲随机分为两组,各49例。对照组治疗采用黄斑区格栅样光凝术,观察组治疗采用黄斑区格栅样光凝术联合雷珠单抗。比较两组术前、术后1个月和6个月黄斑体积（TMV）、DME、最佳矫正视力,术前和术后6个月血清VEGF和IL-6水平,及术后6个月疗效。结果: 两组术后1个月和术后6个月TMV、DME较术前降低,且观察组术后1个月和术后6个月TMV、DME低于对照组。两组术后1个月和术后6个月最佳矫正视力较术前增加;且观察组术后1个月和术后6个月最佳矫正视力高于对照组。两组术后6个月血清VEGF和IL-6水平较术前降低;且观察组术后6个月血清VEGF和IL-6水平低于对照组。观察组术后6个月总有效率高于对照组。结论: 黄斑区格栅样光凝联合雷珠单抗对DME患者治疗疗效良好,可有效改善患者视力,减轻患者黄斑水肿程度,降低血清IL-6和VEGF水平,值得临床借鉴。

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	唐会超
	李满
	王冬梅
	周玉
	庞久彦
	杨威
	刘星雨

关键词 ：黄斑区格栅样光凝, 雷珠单抗, 糖尿病性黄斑水肿, 最佳矫正视力, 血管内皮生长因子, 白介素-6

Abstract：Objective To explore the effect of grid like photocoagulation in the macular region combined with Leizumab on serum Vascular endothelial growth factor (VEGF) and interleukin-6(IL-6) levels in patients with diabetes macular edema (DME). Methods Patients with DME 98 cases admitted to Chengdu 363 Hospital from January 2021 to January 2023 were selected and randomly divided into two groups using a single blind randomized control method based on a random number table, with 49 patients in each group. The patients in the control group were treated with macular grid photocoagulation, and the patients in the observation group were treated with macular grid photocoagulation combined with leizumab. There were compared two groups preoperative, postoperative 1 month and 6 TMV, CME and corrected best visual, before operation and 6 months after operation serum VEGF and IL-6, and 6 months after operation curative effect. Results Compared preoperative, TMV and CME of to groups were decreased at postoperative 1 month and 6 months and in the observation group were lower than those in the Compared preoperative, two groups best corrected visual acuity were increased of postoperative 1 month and 6 months; at postoperative 1 month and 6 months, observation group best corrected visual acuity higher control group. Compared preoperative, two groups serum VEGF and IL-6 levels were decreased of postoperative 6 months; at postoperative 6 months, observation group serum VEGF and IL-6 levels lower control group. At postoperative 6 months, observation group total effective rate was higher than control group. Conclusion Macular grid photocoagulation combined with rezumab is effective in treating DME, it can effectively improve vision, and relieve macular edema, and reduce serum IL-6 and VEGF levels.

Key words： macular grid photocoagulation leizumab diabetic macular edema best corrected vision vascular endothelial growth factor interleukin-6

收稿日期: 2024-03-07

中图分类号:

R77

基金资助:四川省卫生和计划生育委员会科研课题“人眼黄斑区色素光密度与神经节细胞-内丛状层厚度的相关性研究”（18PJ090）

通讯作者: 刘星雨,E-mail：18080801656@163.com

引用本文:

唐会超, 李满, 王冬梅, 周玉, 庞久彦, 杨威, 刘星雨. 黄斑区格栅样光凝联合雷珠单抗对糖尿病性黄斑水肿患者血清VEGF和IL-6水平影响[J]. 湖南师范大学学报(医学版), 2024, 21(3): 51-54. TANG Huichao, LI Man, WANG Dongmei, ZHOU Yu, PANG Jiuyan, YANG Wei, LIU Xingyu. Effects of grid like photocoagulation in macular region combined with ranzumab on serum VEGF and IL-6 levels in patients with diabetes macular edema. HuNan ShiFan DaXue XueBao(YiXueBan), 2024, 21(3): 51-54.

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http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2024/V21/I3/51

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