Abstract：Objective To explore the influencing factors of peripherally inserted central catheter (PICC) -related infections in low birth weight infants in the Neonatal Intensive Care Unit (NICU) and provide a basis for PICC placement in NICUs. Methods We included low birth weight infants who were hospitalized in a tertiary hospital in Changsha City from January 2021 to June 2022 and underwent PICC placement. We retrospectively analyzed their clinical data, used a case-control method, with those who experienced catheter-related infections as the case group and those who did not as the control group. We conducted univariate and multivariate logistic regression analyses to investigate the risk factors for catheter-related bloodstream infections. Results A total of 19 low birth weight infants developed catheter-related bloodstream infections during a total catheterization duration of 3,466 days, with an infection rate of 0.5% per catheter day. The results of logistic regression analysis showed that birth weight<1 000 g (OR=0.266, 95% CI 0.084-0.842) and catheterization age≤7 days (OR=0.193, 95% CI 0.057-0.653) were risk factors. Birth weight and the age at catheter placement, when combined, have a maximum area under the curve of 0.741 and an approximate odds ratio of 0.369. This combination is more effective in predicting Catheter-related bloodstream infection in low birth weight infants compared to individual factors alone. Conclusion For low birth weight infants, especially those with a birth weight of less than 1 000 g and premature infants with catheter placement at ≤7 days of age, increased vigilance and preventive measures should be taken to reduce the occurrence of Catheter-related bloodstream infection.
2024, Vol. 21 
