Objective To investigate the correlation between serum biomarker levels and the severity of patients with acute pancreatitis and its predictive value. Methods A total of 209 patients with acute pancreatitis (AP) who were treated in the Third People's Hospital of Chengdu from January 2019 to June 2025 were selected and categorized into mild AP (MAP) group, moderately severe AP (MSAP) group and severe AP (SAP) group according to the severity of the disease. The general data and serum biomarker levels of the three groups were compared and analyzed. Multivariate logistic regression analysis was used to analyze the correlation between each index and the severity of AP patients, and the receiver operating characteristic (ROC) curve was used to verify its predictive performance. Results There were statistically significant differences in neutrophil/lymphocyte ratio (NLR), red blood cell distribution width (RDW), fibrinogen (FIB), D-dimer (D-D), triglyceride (TG), blood calcium (Ca2+), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and C-reactive protein (CRP) levels among the three groups (P<0.05). The levels of NLR, FIB, D-D, TG, AST, LDH and CRP in the SAP group were higher than those in the MAP and MSAP groups, and the levels of Ca2+ were lower than those in the MAP and MSAP groups (P<0.05). The levels of NLR, RDW, FIB, D-D, TG and LDH in the MSAP group were higher than those in the MAP group (P<0.05). NLR (OR=1.451), RDW (OR=1.632), TG (OR=1.355) and AST (OR=1.043) were independent influencing factors for the progression of AP to SAP (P<0.05). The area under the curve of single and combined detection of NLR, RDW, TG and AST in the diagnosis of SAP were 0.787, 0.784, 0.743, 0.778 and 0.941, respectively. Conclusion NLR, RDW, TG and AST are closely related to the severity of AP patients, and the combined prediction efficacy is favorable.
Key words
serum biomarker /
acute pancreatitis /
correlation /
predictive value
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