Associations between Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio and Mortality in Patients with Ischemic Stroke Complicated by Pulmonary Infection: Based on the MIMIC-IV Database

YU Pei; XIA Wei; FU Ting; TANG Jialong

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Journal of Hunan Normal University(Medical Science) ›› 2026, Vol. 23 ›› Issue (3) : 80-85.

Associations between Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio and Mortality in Patients with Ischemic Stroke Complicated by Pulmonary Infection: Based on the MIMIC-IV Database

YU Pei¹, XIA Wei², FU Ting¹, TANG Jialong³

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Abstract

Objective To investigate the relationship between NLR, PLR and post-hospital mortality in ischemic stroke patients with pulmonary infection, aiming to provide a basis for clinical treatment strategies. Methods We retrospectively collected data from the MIMIC-Ⅳ 3.0 database of patients with ischemic stroke complicated by pulmonary infection who met the study criteria. Using a tertile method, NLR and PLR were each divided into three groups. NLR and PLR were assessed in relation to patient survival and mortality risk using Kaplan-Meier (K-M) survival curves and Cox risk models. Subgroup analyses were also performed to explore differences between different subgroups. Results A total of 2249 patients with ischemic stroke complicated by pulmonary infection were included. K-M survival curves indicated that patients with NLR of 4.49~39.10 and PLR>810.12 had lower post-hospital mortality rates. Cox model showed that patients with an NLR>39.10 and a PLR between 0.54~138.85 had an increased risk of post-hospital mortality. Subgroup analysis revealed a significant association between NLR and post-hospital mortality in patients with ischemic stroke complicated by pulmonary infection and malignant tumors, and between PLR and post-hospital mortality in patients with ischemic stroke complicated by pulmonary infection and malignant tumors or metastatic solid tumors. Conclusion Combined assessment of the NLR and PLR has a certain predictive value for the risk of mortality in patients with ischemic stroke with pulmonary infection, providing a reference for the diagnosis and treatment of this disease.

Key words

MIMIC-Ⅳ / ischemic stroke complicated by pulmonary infection / mortality / neutrophil/lymphocyte ratio / platelet/lymphocyte ratio

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YU Pei, XIA Wei, FU Ting, TANG Jialong. Associations between Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio and Mortality in Patients with Ischemic Stroke Complicated by Pulmonary Infection: Based on the MIMIC-IV Database[J]. Journal of Hunan Normal University(Medical Science). 2026, 23(3): 80-85

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