Objective To analyze the cartilage repair effect of Ruanshang Lotion on patients with knee osteoarthritis (KOA). Methods A total of 152 KOA patients admitted to our hospital from May 2020 to March 2025 were randomly divided into two groups (76 cases each) using a random number table. The control group received conventional KOA treatment, while the observation group received Ruanshang Lotion in addition to the conventional treatment. The clinical efficacy, TCM syndrome scores, levels of inflammatory factors, knee joint recovery, deep cartilage repair, and cartilage tissue indicators were compared between the two groups. Results After treatment, 74 cases were included in the observation group and 72 in the control group. The total effective rate in the observation group (89.19%) was higher than that in the control group (76.39%) (P<0.05). The TCM syndrome scores in both groups decreased compared with those before treatment, and were lower in the observation group than in the control group (P<0.05). After 4 weeks of treatment and at the end of treatment, the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in both groups decreased compared with those before treatment (P<0.05), and were lower in the observation group than in the control group (P<0.05). After 4 weeks of treatment and at the end of treatment, the index of severity for osteoarthritis (ISOA), visual analog scale (VAS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores in both groups decreased compared with those before treatment, and were lower in the observation group than in the control group (P<0.05). Before treatment, there were no statistically significant differences between the two groups in the levels of C-telopeptide of type Ⅱ collagen (CTX-Ⅱ), cartilage oligomeric matrix protein (COMP), matrix metalloproteinase-13 (MMP-13), or a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) (P>0.05). After 4 weeks of treatment and after 8 weeks of treatment, the levels of CTX-Ⅱ, COMP, MMP-13, and ADAMTS4 in both groups decreased compared with those before treatment; however, there were no statistically significant differences between the two groups in CTX-Ⅱ, COMP, or MMP-13 (P>0.05), while ADAMTS4 in the observation group was lower than that in the control group (P<0.05). After 8 weeks of treatment, the levels of CTX-Ⅱ, COMP, MMP-13, and ADAMTS4 in the observation group were lower than those in the control group (P<0.05). During the treatment period, there was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The application of Ruanshang Lotion in the treatment of patients with knee osteoarthritis can reduce the body's inflammatory response, alleviate cartilage damage, relieve clinical symptoms, improve clinical efficacy, and does not increase the incidence of adverse reactions.
Key words
Ruanshang Lotion /
knee osteoarthritis /
cartilage repair /
clinical efficacy
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] GELBER AC. Knee osteoarthritis[J]. Ann Intern Med, 2024, 177(9): ITC129-ITC144.
[2] SONOBE T, OTANI K, SEKIGUCHI M, et al.Influence of knee osteoarthritis severity, knee pain, and depression on physical function: a cross-sectional study[J]. Clin Interv Aging, 2024, 19: 1653-1662.
[3] KOLASINSKI SL, NEOGI T, HOCHBERG MC, et al.2019 American college of rheumatology/arthritis foundation guideline for the management of osteoarthritis of the hand, hip, and knee[J]. Arthritis Care Res, 2020, 72(2): 149-162.
[4] KAN HS, CHAN PK, CHIU KY, et al.Non-surgical treatment of knee osteoarthritis[J]. Hong Kong Med J, 2019, 25(2): 127-133.
[5] 于长禾,周彦吉,安易,等. 基于多阶段优化策略构建中医治疗膝骨关节炎的综合方案[J]. 中华中医药杂志, 2023, 38(7): 3383-3387.
[6] 夏志宏, 李亦凡, 朱泽, 等. 独活寄生汤加减口服联合膝关节镜清理术治疗膝关节骨性关节炎临床疗效及对膝关节液炎症因子的影响[J]. 四川中医, 2021, 39(7): 150-152.
[7] 王琼, 李信明, 任正强, 等. 浮针治疗早中期膝骨关节炎对软骨厚度的影响[J]. 上海针灸杂志, 2024, 43(4): 416-421.
[8] 严命祥, 马天明, 李同军, 等. 经筋手法联合穴位熏蒸治疗膝骨关节炎 (寒湿痹阻证) 的临床观察[J]. 中国中医急症, 2025, 34(5): 828-831.
[9] 王波, 余楠生. 膝骨关节炎阶梯治疗专家共识 (2018年版)[J]. 中华关节外科杂志 (电子版), 2019, 13(1): 124-130.
[10] 陈卫衡, 刘献祥, 童培建, 等. 膝骨关节炎中医诊疗专家共识 (2015年版)[J]. 中医正骨, 2015, 27(7): 4-5.
[11] 中医骨伤科临床诊疗指南·膝痹病 (膝骨关节炎)[J]. 康复学报, 2019, 29(3): 1-7.
[12] 郑筱萸. 中药新药临床研究指导原则: 试行[M]. 北京: 中国医药科技出版社, 2002.
[13] HOY DG, SMITH E, CROSS M, et al.The global burden of musculoskeletal conditions for 2010: an overview of methods[J]. Ann Rheum Dis, 2014, 73(6): 982-989.
[14] CROSS M, SMITH E, HOY D, et al.The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study[J]. Ann Rheum Dis, 2014, 73(7): 1323-1330.
[15] 严广斌. 视觉模拟评分法[J]. 中华关节外科杂志 (电子版), 2014, 8(2): 273.
[16] 邹金宏, 梁翼, 李敏, 等. “筋骨并重、内外兼治”理论指导下运用中医药辨证治疗膝骨关节炎的临床疗效[J]. 四川中医, 2024, 42(10): 130-133.
[17] 李海冰, 杨雪芬, 李彬, 等. 中西医结合疗法对瘀血阻滞型膝骨关节炎的影响——评《中西医结合治疗骨关节病》[J]. 世界中医药, 2024, 19(14): 2212.
[18] 丁洪磊, 李佃波, 周源, 等. 崔述生从“风痰瘀络”论治膝骨关节炎[J]. 中国中医骨伤科杂志, 2020, 28(11): 79-81.
[19] 许晚舟, 李海婷, 郭珈宜, 等. 中医药调控细胞焦亡治疗膝骨关节炎[J]. 中医学报, 2024, 39(2): 319-324.
[20] 李炜. 中药方剂联合针刀疗法治疗瘀血阻滞型膝骨关节炎的临床研究——评《膝骨性关节炎的中西医结合诊治》[J]. 世界中医药, 2024, 19(12): 1875.
[21] 刘大鹏, 王海波, 陈晨, 等. 崔氏软伤洗剂联合推拿治疗缓解期膝骨关节炎患者的临床疗效[J]. 世界中西医结合杂志, 2024, 19(10): 2067-2071.
[22] 康乾,晋春阳,王若秦,等.膝骨关节炎病因学及发病机制的研究进展[J].临床骨科杂志, 2025, 28(6):899-904.
[23] 王烨航, 宋红, 余王琴. 肾着汤调控PI3K-Akt信号通路抑制软骨细胞凋亡改善膝骨关节炎大鼠炎症水平机制研究[J]. 中国中药杂志, 2025(12): 3389-3398.
[24] 李晓峰, 刘元禄, 关雪峰, 等. 补肾活血方剂治疗膝骨关节炎研究进展[J]. 辽宁中医药大学学报, 2023, 25(10): 142-146.
[25] 王涛, 王钢, 王佳, 等. 中药熏洗联合西药治疗寒湿痹阻型膝骨关节炎的临床观察[J]. 中国骨质疏松杂志, 2017, 23(4): 506-510.
[26] QIAO J, GUO X, ZHANG L, et al.Autologous platelet rich plasma injection can be effective in the management of osteoarthritis of the knee: impact on IL-1β, TNF-α, hs-CRP[J]. J Orthop Surg Res, 2024, 19(1): 703.
[27] ZHANG J, LI K, QIU X.Exploring causal correlations between inflammatory cytokines and knee osteoarthritis: a two-sample Mendelian randomization[J]. Front Immunol, 2024, 15: 1362012.
[28] NEGISHI Y, ADILI A, DE VEGA S, et al.IL-6 reduces spheroid sizes of osteophytic cells derived from osteoarthritis knee joint via induction of apoptosis[J]. Am J Pathol, 2024, 194(1): 135-149.
[29] 侯露瑜. 基于数据挖掘及网络药理学探讨孟祥震教授治疗类风湿关节炎的临床经验及作用机制[D]. 天津: 天津中医药大学, 2025.
[30] 李慧, 马玉环, 许丽梅, 等. 独活寄生汤拆方通过Wnt/β-catenin信号通路抑制软骨细胞炎症反应[J]. 中国组织工程研究, 2020, 24(35): 5589-5594.
[31] 夏雪, 沈霖, 凌家艳, 等. 加味阳和汤治疗寒湿痹阻型膝骨关节炎的疗效及对炎症因子的影响[J]. 中国中医骨伤科杂志, 2024, 32(3): 55-58.
[32] 郭从嘉, 吴国泰, 高慧琴, 等. 秦艽与威灵仙组分配伍对类风湿关节炎大鼠的治疗作用[J]. 中国临床药理学杂志, 2023, 39(21): 3139-3143.
[33] 胡可馨, 周可林, 严雪儿, 等. 基于数据挖掘总结崔述生治疗膝关节骨性关节炎外治用药规律[J]. 北京中医药, 2022, 41(1): 77-81.
PDF(2041 KB)
