Effect of Press-Needle Combined with Eptazocine on Improving Acute Postoperative Pain and Its Influence on Neuroimmune Markers in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma

CHEN Jiang; XIA Huan; ZHI Hangyu; MENG Xin; GUO Mian; YAO Cong

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Journal of Hunan Normal University(Medical Science) ›› 2026, Vol. 23 ›› Issue (3) : 6-10.

Effect of Press-Needle Combined with Eptazocine on Improving Acute Postoperative Pain and Its Influence on Neuroimmune Markers in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma

CHEN Jiang¹, XIA Huan¹, ZHI Hangyu¹, MENG Xin¹, GUO Mian², YAO Cong³

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Abstract

Objective To investigate the clinical effect of press needle combined with eptazocine on acute pain after hepatectomy for liver cancer based on neuroimmune regulation mechanism. Methods Eighty patients undergoing hepatectomy for liver cancer were randomly divided into observation group (press needle + eptazocine) and control group (eptazocine), with 40 cases in each group, treated continuously for 3 days. Serum levels of β-endorphin, substance P, IFN-γ, IL-10, and inflammatory factors (IL-4, IL-6, TNF-α) were measured in both groups. Visual Analogue Scale (VAS) score, Karnofsky Performance Status (KPS) score, cumulative eptazocine consumption, adverse reactions, and total effective rate of analgesia were evaluated within 72 hours postoperatively. Results The levels of β-endorphin in the observation group were higher than those in the control group at 48 h and 72 h postoperatively (P<0.05). At each time point, the levels of substance P, IFN-γ, IL-6, TNF-α and VAS scores in the observation group were lower than those in the control group, while the levels of IL-10, IL-4 and KPS scores were higher than those in the control group (P<0.05). The cumulative eptazocine consumption and incidence of adverse reactions in the observation group were lower than those in the control group, and the total effective rate of analgesia in the observation group (100%) was higher than that in the control group (85%) (P<0.05). Conclusion Press needle combined with eptazocine can enhance the analgesic effect after hepatectomy and reduce the dosage of eptazocine and adverse reactions. The mechanism may be related to the regulation of neuroimmune axis and inhibition of inflammation.

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hepatectomy / multimodal analgesia / neuroimmunity / press needle / eptazocine

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CHEN Jiang, XIA Huan, ZHI Hangyu, MENG Xin, GUO Mian, YAO Cong. Effect of Press-Needle Combined with Eptazocine on Improving Acute Postoperative Pain and Its Influence on Neuroimmune Markers in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma[J]. Journal of Hunan Normal University(Medical Science). 2026, 23(3): 6-10

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