Meta-Analysis of Human Papillomavirus Detection in High-Risk Female Populations for Sexually Transmitted Disease

ZHANG Qiaorou; YANG Ying

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Journal of Hunan Normal University(Medical Science) ›› 2026, Vol. 23 ›› Issue (3) : 161-168.

Preventive Medicine

Meta-Analysis of Human Papillomavirus Detection in High-Risk Female Populations for Sexually Transmitted Disease

ZHANG Qiaorou, YANG Ying

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Abstract

Objective To systematically evaluate the distribution characteristics of human papillomavirus (HPV) infection among in high-risk female populations for sexually transmitted disease. Methods Studies on HPV infection in high-risk female populations for sexually transmitted disease were retrieved from 7 databases (from the establishment of the database to May 2025). The quality of the articles that met the requirements was evaluated. Stata 18.0 and Review Manager 5.4 software were used for Meta-analysis. Results A total of 12 studies were included. Meta-analysis showed that the pooled prevalence of HPV infection among high-risk female populations for sexually transmitted disease was 41.3% (95% CI: 28.1%-54.5%). Low educational level was a significant risk factor for infection (OR=26.28, 95% CI: 7.41-93.62); smoking (OR=0.35, 95% CI: 0.12-0.98), history of other sexually transmitted infections (STI) (OR=0.11, 95% CI: 0.02-0.78), and younger age at first sexual intercourse (OR=0.07, 95% CI: 0.03-0.18) were associated with a risk of infection. No publication bias was detected in the analyses of the infection rate or the above factors. Conclusion The HPV infection rate among high-risk female populations for sexually transmitted disease is relatively high, and it is significantly associated with low educational level, smoking, a history of concurrent STI, and a young age at first sexual intercourse. This group is a key target for cervical cancer prevention and control, and comprehensive intervention measures need to be taken.

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high-risk female populations for sexually transmitted disease / human papillomavirus / risk factors / meta-analysis

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ZHANG Qiaorou, YANG Ying. Meta-Analysis of Human Papillomavirus Detection in High-Risk Female Populations for Sexually Transmitted Disease[J]. Journal of Hunan Normal University(Medical Science). 2026, 23(3): 161-168

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