Objective To investigate the predictive efficacy of the non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (NHHR) on the thickening of carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 360 patients with T2DM in our hospital from July 2022 to May 2024 were selected as the research subjects. According to whether they developed thickening of CIMT, they were divided into the simple T2DM group (n=208) and the CIMT thickening group (n=152). Compare the general data and NHHR of the two groups, analyze the correlations between each indicator and the thickening of CIMT, analyze the influencing factors of CIMT thickening in patients with T2DM, and analyze the predictive value of NHHR for CIMT thickening in patients with T2DM. Results The CIMT thickening group had higher levels of total cholesterol (TC), duration of T2DM, non-high-density lipoprotein cholesterol (non-HDL-C), hemoglobin A1c (HbA1c), high-density lipoprotein cholesterol (HDL-C), and NHHR compared to the simple T2DM group, the low-density lipoprotein cholesterol (LDL-C) was lower in the CIMT thickening group than in the simple T2DM group. The course of T2DM, non-HDL-C, HbA1c, NHHR, TC, HDL-C are positively correlated with CIMT thickening, while LDL-C is negatively correlated with CIMT thickening; after adjusting for T2DM duration, non-HDL-C, and HbA1c, NHHR remained an influencing factor for the thickening of CIMT in T2DM patients; the areas under the curve for non-HDL-C, HDL-C, and NHHR in predicting the thickening of CIMT in patients were 0.705, 0.846, and 0.895 respectively, and the predictive efficacy of NHHR was significantly higher than that of HDL-C. Conclusion The increase in NHHR in patients with T2DM is associated with the thickening of CIMT. Compared with non-HDL-C and HDL-C alone, NHHR has a higher predictive efficacy in predicting the thickening of CIMT in patients.
Key words
non-high-density lipoprotein cholesterol /
type 2 diabetes /
high-density lipoprotein cholesterol /
carotid intima-media thickness /
thickening /
prediction
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