Factors Influencing the Outcome of Patients with Previous ACI after Stent Thrombectomy and Their Effects on Vaspin and Apelin Levels

QIN Xingyue; XIAO Hai; CHEN Shengchang; QIN Zhugui; NONG Yuan

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Journal of Hunan Normal University(Medical Science) ›› 2026, Vol. 23 ›› Issue (1) : 66-70.

Factors Influencing the Outcome of Patients with Previous ACI after Stent Thrombectomy and Their Effects on Vaspin and Apelin Levels

QIN Xingyue, XIAO Hai, CHEN Shengchang, QIN Zhugui, NONG Yuan

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Abstract

Objective To explore the factors influencing the prognosis of patients with anterior circulation acute cerebral infarction (ACI) after stent thrombectomy and the effects on the levels of visceral adipose tissue-derived serine proteinase inhibitor (Vaspin) and Apelin. Methods 112 patients with anterior circulation acute cerebral infarction who underwent stent thrombectomy in our hospital from March 2022 to March 2025 were selected as the research subjects. The modified Rankin Scale score was used to evaluate the outcome 3 months after the operation. The patients were divided into the good outcome group (73 cases) and the poor outcome group (39 cases) based on the postoperative outcome. Compare the general data of the two groups, analyze the influencing factors of the outcome after anterior circulation ACI stent thrombectomy, compare the serum levels of Vaspin and Apelin in the two groups, and analyze the predictive efficacy on the postoperative outcome of patients. Results There were statistically significant differences between the two groups in terms of age, NIHSS score at admission, ASPECT score at admission, occlusion site, complete postoperative blood flow reperfusion, and postoperative cerebral hemorrhage. Age and the NIHSS score on admission are risk factors for poor outcomes after stent retriever thrombectomy in patients with anterior circulation acute ischemic stroke. The ASPECT score on admission and complete reperfusion of blood flow post-procedure are protective factors against poor outcomes in these patients; The serum levels of Vaspin and Apelin in the poor outcome group were lower than those in the good outcome group. The receiver operating characteristic curve (ROC) evaluated the predictive performance of the aforementioned factors for poor outcomes after stent retriever thrombectomy in patients with anterior circulation acute cerebral infarction, showing that the combined detection of these factors yielded the largest area under the curve (AUC). Conclusion Factors associated with poor post-procedural outcomes after anterior circulation acute ischemic stroke thrombectomy include age and admission NIHSS score, whereas admission ASPECTS score and complete reperfusion post-procedure are protective factors. Combining these factors with serum Vaspin and Apelin levels can enhance the predictive accuracy for poor post-procedural outcomes in patients.

Key words

anterior circulation / acute cerebral infarction / stent thrombectomy / outcome / fatty-specific serine protease inhibitor / aApelin peptide

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QIN Xingyue, XIAO Hai, CHEN Shengchang, QIN Zhugui, NONG Yuan. Factors Influencing the Outcome of Patients with Previous ACI after Stent Thrombectomy and Their Effects on Vaspin and Apelin Levels[J]. Journal of Hunan Normal University(Medical Science). 2026, 23(1): 66-70

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