Objective To investigate the application effect of an automatic dispenser in the compounding of commonly used Traditional Chinese Medicine (TCM) injections in PIVAS. Methods From May 22 to June 10, 2025, Compound Kushen Injection, Shenkang Injection, and Kangai Injection compounded at the PIVAS of Shenzhen Hospital of Guangzhou University of Chinese Medicine were enrolled. Samples were categorized into a manual group and an ultra-clean dispensing device group according to the preparation technique. The sample sizes comprised 200 prescriptions each for Kangai and Compound Kushen Injections (split evenly into 100 per group) and 80 prescriptions for Shenkang Injection (40 per group). The efficiency of manual versus automatic dispenser, residual drug volume, compounding stability, microbial detection rates in residual solution/syringes and air cleanliness were compared. Results When compounding three types of Traditional Chinese Medicine injections, the average preparation time per bag in the ultra-clean dispensing device group was significantly shorter than that in the manual group for both compound Kushen Injection and Shenkang Injection [(42.40±3.364) s vs (46.65±4.722) s and (55.18±4.299) s vs (63.90±5.891) s, respectively]. However, no significant difference in preparation time was observed between the two groups for Kangai Injection [(60.05±3.886) s vs (60.96±4.829)]. In the present study most coefficients of variation for compounding time and residual volume were small when using the automatic dispenser. No statistically significant differences were observed in residual drug volume. Under the current research conditions, the introduction of the automatic dispenser has no significant impact on the microbial detection of the inner surface of dispensing syringes, residual medication or air cleanliness. Conclusion Taking Kang'ai Injection, Compound Kushen Injection, and Shenkang Injection as examples, the automatic dispenser significantly reduces the compounding time per bag of finished infusion solution and makes it more stable time. No significant adverse effects were observed on the residual drug volume or microbial test results. This provides a promising option for PIVAS to explore standardized procedures and intelligent compounding.