Objective To evaluate the intervention effect of Xingnao Kaiqiao acupuncture combined with flunarizine hydrochloride on clinical symptoms, cerebral hemodynamics and neural vasoactive substances in patients with migraine. Methods A total of 132 patients with migraine admitted to the hospital were enrolled between January 2022 and June 2025. According to different treatment methods, they were divided into flunarizine group (flunarizine hydrochloride), acupuncture group (Xingnao Kaiqiao acupuncture) and combination group (Xingnao Kaiqiao acupuncture combined with flunarizine hydrochloride), 44 cases in each group. The headache control (duration, onset frequency, severity), scores of TCM symptoms, cerebral hemodynamics[anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA), resistance index (RI), pulsatility index (PI) ]and neural vasoactive substances[calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), S100B protein, substance P (SP) ]were compared among the three groups, and adverse reactions in the three groups were observed. Results After treatment, onset frequency and severity of headache were decreased in the three groups, which were lower in combination group, and headache duration was shortened, which was shorter in combination group. After treatment, scores of TCM symptoms, ACA, MCA, PCA, RI, PI, CGRP, PACAP, S100B protein and SP were decreased in the three groups, which were lower in combination group. There was no significant difference in the incidence of adverse reactions among the three groups. Conclusion Xingnao Kaiqiao acupuncture combined with flunarizine hydrochloride can effectively improve headache symptoms in migraine patients, optimize local cerebral blood flow and inhibit neural vasoactive substances, which is worthy of clinical application and reference.
Key words
migraine /
Xingnao Kaiqiao acupuncture /
flunarizine hydrochloride /
cerebral hemodynamics /
neural vasoactive peptide
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