Objective To evaluate the application value of low temperature plasma ablation (LTPA) in young and middle-aged patients with sinonasal inverted papilloma (SNIP) based on nasal function and stress response. Methods A retrospective collection of 91 young and middle-aged SNIP patients admitted to Zhangjiagang Hospital of Traditional Chinese Medicine from December 2019 to January 2024 was conducted as the research subjects. They were divided into the control group (45 cases) and the observation group (46 cases) according to different surgical plans. The control group received nasal endoscopic surgery, and the observation group received nasal endoscopic surgery +LTPA. The clinical efficacy, surgical indicators, stress response indicators [epinephrine (E), norepinephrine (NE), cortisol (Cor)], nasal function, sinonasal outcometest-20(SNOT-20) scoring, and the occurrence of postoperative complications and recurrence one year after the operation. Result The total effective rate of the observation group was 95.65%, significantly higher than that of the control group (82.22%). the intraoperative blood loss, postoperative bleeding time and surgical cavity recovery time in the observation group were all lower than those in the control group. On postoperative day 1 and 3, the levels of Cor, E and NE in the observation group were lower than those in the control group. Three months after the operation, the ciliary clearance rate and ciliary clearance speed in the observation group were higher than those in the control group, while the nasal airway resistance, saccharin clearance time and SNOT-20 score were lower than those in the control group. The incidence of complications in the observation group was 6.52%, compared with 13.33% in the control group, and the differences were not statistically significant. The one-year recurrence rate in the observation group was 2.17%, which was lower than that 13.33% in the control group. Conclusion LTPA treatment has a significant effect on young and middle-aged patients with SNIP. It can improve the stress response and nasal function of patients and reduce the recurrence rate one year after the operation.
Key words
nasal function /
stress response /
low-temperature plasma ablation /
middle-aged and young people /
inverted papilloma of the nasal cavity and paranasal sinuses
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