Study on the Correlation between Changes in Levels of Alpha Fetoprotein and Tumor Necrosis Factor-&#x003b1; and the Efficacy and Prognosis of Transcatheter Arterial Chemoembolization in Advanced Primary Liver Cancer

YANG Guangyao; DAI Bin; WANG Wei; ZHOU Cheng

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Journal of Hunan Normal University(Medical Science) ›› 2026, Vol. 23 ›› Issue (1) : 158-161.

Study on the Correlation between Changes in Levels of Alpha Fetoprotein and Tumor Necrosis Factor-α and the Efficacy and Prognosis of Transcatheter Arterial Chemoembolization in Advanced Primary Liver Cancer

YANG Guangyao, DAI Bin, WANG Wei, ZHOU Cheng

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Abstract

Objective Investigating the correlation between changes in alpha-fetoprotein (AFP) and tumor necrosis factor-α (TNF-α) Levels and the therapeutic efficacy of transarterial chemoembolization (TACE) in Patients with intermediate to advanced primary liver cancer. Methods This study is a retrospective study, with data sourced from the medical records of patients with advanced primary liver cancer who underwent TACE treatment and were admitted to our hospital from March 2022 to April 2023. Patients were categorized into the effective group [complete response (CR) + partial response (PR) + stable disease (SD)] and the ineffective group [progressive disease (PD)] based on treatment efficacy. The relationship between serum AFP, TNF-α expression, and the prognosis of TACE treatment in patients with advanced primary liver cancer was analyzed. Results 82 patients with primary liver cancer were included in TACE treatment and divided into an effective group (CR+PR+SD, 63 cases) and an ineffective group (PD, 19 cases). There was no significant difference in baseline data between groups. The levels of AFP and TNF-α in the effective group were lower than those in the ineffective group. Before treatment, when the clinical stage increases or the tumor boundary is irregular, the serum AFP and TNF-α values increase. ROC analysis showed that the AUC for predicting prognosis by combining AFP and TNF - α was 0.913. Conclusion The changes in serum AFP and TNF-α levels are closely related to the postoperative efficacy of TACE in advanced primary liver cancer and can be used as prognostic indicators.

Key words

intermediate to advanced primary liver cancer / transarterial chemoembolization (TACE) / alpha-fetoprotein (AFP) / tumor necrosis factor-alpha (TNF-α) / therapeutic efficacy

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YANG Guangyao, DAI Bin, WANG Wei, ZHOU Cheng. Study on the Correlation between Changes in Levels of Alpha Fetoprotein and Tumor Necrosis Factor-α and the Efficacy and Prognosis of Transcatheter Arterial Chemoembolization in Advanced Primary Liver Cancer[J]. Journal of Hunan Normal University(Medical Science). 2026, 23(1): 158-161

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