Objective To investigate the correlation between serum magnesium levels and neonatal bacteria infectious jaundice and its clinical significance in this condition. Methods A total of 136 neonates diagnosed with jaundice at our hospital from May 2022 to May 2025 were enrolled and divided into the non-infectious jaundice group (n=84) and the infectious jaundice group (n=52) based on etiological examinations. Clinical data were collected for univariate analysis, receiver operating characteristic (ROC) curve analysis to evaluate the predictive value of serum magnesium, and Pearson correlation analysis. Results The infectious jaundice group had significantly higher proportions of jaundice resolution time>5 days, liver function injury, moderate and severe disease severity, and levels of serum magnesium, CRP, PCT, and TcB than the non-infectious jaundice group. Serum magnesium showed good predictive value for neonatal bacteria infectious jaundice (AUC=0.801, P<0.05). In neonatal bacteria jaundice, the high-serum-magnesium group had significantly higher proportions of jaundice resolution time>5 days and levels of CRP, PCT, and TcB than the low-serum-magnesium group, and CRP, PCT, and TcB levels were significantly positively correlated with serum magnesium levels. In neonatal infectious jaundice, the high-serum-magnesium group had significantly higher proportions of moderate and severe disease severity and levels of CRP, PCT, and TcB than the low-serum-magnesium group, and only CRP and PCT levels were significantly positively correlated with serum magnesium levels. Conclusion Infants with infectious jaundice have prolonged jaundice resolution time, liver function injury, increased disease severity, and elevated levels of serum magnesium, CRP, PCT, and TcB. Among them, serum magnesium has good predictive value and is positively correlated with CRP and PCT levels in neonatal bacteria infectious jaundice. The results of this study can, to a certain extent, provide a reference for developing early prevention and non-invasive diagnostic tools in clinical practice.
Key words
infectious jaundice /
neonate /
serum magnesium /
clinical significance
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] HALLIDAY H L, SPEER C P.Global Neonatal Research[J]. Neonatol, 2021, 118(3): 257-258.
[2] 郭健, 王文涛, 周启立, 等. 高压氧联合茵栀黄口服液治疗儿童湿热郁蒸证感染性黄疸的临床效果[J]. 中华医院感染学杂志, 2022, 32(04): 590-594.
[3] ZAHED PASHA Y, ALIZADEH-TABARI S, ZAHED PASHA E, et al.Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis[J]. World J Pediatr, 2020, 16(5): 480-493.
[4] BELAY H G, DEBEBE G A, AYELE A D, et al.Determinants of neonatal jaundice in Ethiopia: a systematic review and meta-analysis[J]. World J Pediatr, 2022, 18(11): 725-733.
[5] LIU Y, SUN X, WANG Y, et al.Evaluation of Associated Markers of Neonatal Pathological Jaundice Due to Bacterial Infection[J]. Iran J Public Health, 2021, 50(2): 333-340.
[6] EGHBALIAN F, SHABANI S, FARADMAL J, et al.Effects of Phototherapy on the Serum Magnesium Level in Neonates with Indirect Hyperbilirubinemia: A Prospective Cohort Study[J]. Int J Pediatr, 2022, 2022(1): 5439630.
[7] 杨静丽, 王建辉.2022版美国儿科学会新生儿高胆红素血症管理指南解读[J]. 中国当代儿科杂志, 2023, 25(01): 11-17.
[8] 王卫平. 儿科学[M]. 第8版. 北京: 人民卫生出版社, 2013.
[9] 代东伶, 文飞球, 蔡华波, 等. 儿童重度肝功能损害临床特点分析[J]. 临床儿科杂志, 2015, 33(10): 846-849.
[10] WEISS S L, PETERS M J, ALHAZZANI W, et al.Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children[J]. Pediatr Crit Care Med, 2020, 21(2): e52-e106.
[11] LE RAY I, WANG C, ALMQVIST C, et al.Neonatal jaundice, attention deficit hyperactivity disorder and familial effects: A Swedish register study with sibling analysis[J]. Acta Paediatr, 2021, 110(2): 473-479.
[12] BARBAGALLO M, VERONESE N, DOMINGUEZ L J.Magnesium in Aging, Health and Diseases[J]. Nutrients, 2021, 13(2): 463.
[13] FIORENTINI D, CAPPADONE C, FARRUGGIA G, et al.Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency[J]. Nutrients, 2021, 13(4): 1136.
[14] MA J, LI L, QIE X, et al.Value of Combined Detection of PCT, CRP, and FIB in Differentiating Viral Infection from Bacterial Infection in Severe Pneumonia[J]. Clin Lab, 2023, 69(11).
[15] RIZO-TéLLEZ S A, SEKHERI M, FILEP J G. C-reactive protein: a target for therapy to reduce inflammation[J]. Front Immunol, 2023, 14: 1237729.
[16] GO H, NAGANO N, SATO Y, et al.Procalcitonin-Based Antibiotic Use for Neonatal Early-Onset Bacterial Infections: Pre- and Post-Intervention Clinical Study[J]. Antibiotics (Basel), 2023, 12(9): 1426.
[17] FELDMAN A G, SOKOL R J.Neonatal Cholestasis: Updates on Diagnostics, Therapeutics, and Prevention[J]. Neoreviews, 2021, 22(12): e819-e836.
[18] 章梦岚, 张旭, 马宏榛. 湿热型黄疸新生儿血清S100B和γ-谷氨酰转肽酶表达与疾病严重程度的相关性[J]. 中国妇幼保健, 2021, 36(07): 1561-1563.
[19] GUITART C, RODRíGUEZ-FANJUL J, BOBILLO-PEREZ S, et al. An algorithm combining procalcitonin and lung ultrasound improves the diagnosis of bacterial pneumonia in critically ill children: The PROLUSP study, a randomized clinical trial[J]. Pediatr Pulmonol, 2022, 57(3): 711-723.
[20] SUN P, YANG J, REN H, et al.Asymptomatic epiploic appendage with torsion in laparoscopic surgery: a case report and literature review[J]. Ann Palliat Med, 2021, 10(7): 8384-8390.
[21] TEN KATE L, VAN OORSCHOT T, WOOLDERINK J, et al.Transcutaneous Bilirubin Accuracy Before, During, and After Phototherapy: A Meta-Analysis[J]. Pediatrics, 2023, 152(6): e2023062335.
[22] OKWUNDU C I, OLOWOYEYE A, UTHMAN O A, et al. Transcutaneous bilirubinometry versus total serum bilirubin measurement for newborns[J]. Cochrane Database Syst Rev, 2023, 5(5): Cd012660.
[23] KEMPER A R, NEWMAN T B, SLAUGHTER J L, et al.Clinical Practice Guideline Revision: Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation[J]. Pediatrics, 2022, 150(3): e2022058859.
PDF(2227 KB)
