Objective To investigate the effects of Solitaire stent thrombectomy combined with intravenous thrombolysis (IVT) on the prognosis, cerebral hemodynamic status, and neurological function in patients with anterior circulation acute ischemic stroke (CIS). Methods The clinical data of 122 patients with CIS treated in our hospital from June 2019 to June 2024 were retrospectively analyzed. According to different treatment methods, the patients were divided into two groups: 60 patients who received IVT alone were included in the control group, and 62 patients who received Solitaire stent thrombectomy combined with IVT were included in the treatment group. Vascular recanalization status and perioperative complications were compared between the two groups. Cerebral hemodynamic indicators, serum nerve factors, and neurological function scores were compared before and after treatment. Results The vascular recanalization rate in the treatment group was higher than that in the control group, and the recanalization time was shorter than that in the control group. There was no significant difference in mortality and total incidence of complications between the two groups. At 24 hours after surgery, cerebral blood flow (CBF), mean velocity (Vm), and end-diastolic velocity (Vd) in both groups were higher than those before surgery, and those in the treatment group were significantly higher than the control group. At 72 hours after surgery, the levels of neuron-specific enolase (NSE) in both groups were lower than those before surgery, with the treatment group showing lower levels than the control group; the levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were higher than those before surgery, with the treatment group showing higher levels than the control group. At discharge, the National Institutes of Health Stroke Scale (NIHSS) scores in both groups were lower than those before surgery, and the score in the treatment group was lower than that in the control group. At 90 days after surgery, the modified Rankin Scale (mRS) scores in both groups were lower than those before surgery, and the score in the treatment group was lower than that in the control group. Conclusion Solitaire stent thrombectomy combined with IVT can significantly enhance the vascular recanalization rate, and improve the cerebral hemodynamic status, neurocognitive function and cerebral neuroprotective factors levels in patients with CIS, and it has high safety.
Key words
solitaire stent /
intravenous thrombolysis /
anterior circulation acute ischemic stroke /
neurological function
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