Objective To investigate the clinical efficacy of ultrasound-guided paravertebral block (UG-PVB) and its regulatory effects on inflammatory factors, including Prostaglandin E2(PGE2), 5-Hydroxytryptamine (5-HT), and Cortisol (Cor), in patients with Lumbar Disc Herniation (LDH) in high-altitude regions. Methods A total of 120 patients with LDH admitted to a hospital in Milin County, Tibet, were enrolled and randomly assigned into an experimental group (n=60) and a control group (n=60) using a random number table. The control group received conventional pharmacological treatment, while the experimental group received additional UG-PVB therapy. Blood levels of PGE2, 5-HT, and Cor were measured before and after treatment in both groups. Visual Analog Scale (VAS), Japanese Orthopaedic Association (JOA) score, and Oswestry Disability Index (ODI) were also evaluated. Results After treatment, the experimental group showed significantly lower VAS scores (3.1±1.2 vs 4.7±1.3) and ODI scores (27.3±5.9 vs 35.9±6.1), and higher JOA scores (22.6±3.5 vs 17.8±3.2) compared to the control group (P<0.001). Reductions in inflammatory markers were more pronounced in the experimental group (ΔPGE2=145.5±68.2 vs 87.3±60.6; Δ5-HT=78.5±42.0 vs 39.6±31.4; ΔCor=144.1±58.9 vs -77.4±56.9, P<0.001). Multiple regression analysis indicated that changes in PGE2 and 5-HT were independently associated with VAS improvement (β=-0.42 and -0.38, respectively; P<0.05). Conclusion UG-PVB is effective in relieving pain caused by LDH in high-altitude environments, potentially through suppression of the PGE2/5-HT-mediated inflammatory pathway.
Key words
high-altitude region /
lumbar disc herniation /
ultrasound-guided intervention /
paravertebral block /
inflammatory markers
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