Incidence and Risk Factors of Sleep Disorders During Radiotherapy for Lung Cancer

ZHANG Chao; WANG Fengjuan; DU Wen; LIU Qi; LI Xia; LIU Fengjuan

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Journal of Hunan Normal University(Medical Science) ›› 2025, Vol. 22 ›› Issue (6) : 203-207.

Clinical Medicine

Incidence and Risk Factors of Sleep Disorders During Radiotherapy for Lung Cancer

ZHANG Chao¹, WANG Fengjuan², DU Wen², LIU Qi¹, LI Xia³, LIU Fengjuan³

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Abstract

Objective To investigate the incidence and risk factors of sleep disorders during radiotherapy for lung cancer and propose preventive suggestions. Methods A total of 206 patients who underwent radiotherapy for lung cancer from January to April 2025 were enrolled in the study. The Pittsburgh Sleep Quality Index (PSQI) was used to assess the incidence of sleep disorders during radiotherapy. The Visual Analog Scale (VAS) was used to evaluate pain intensity. The Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to evaluate psychological states. Patients were divided into the sleep disorder group and the non-sleep disorder group. Clinical data were compared between groups, and a logistic regression model was used to identify risk factors for sleep disorders during radiotherapy. Results The incidence of sleep disorders was 24.27% (50 cases) before radiotherapy, 33.98% (70 cases) after 2 week of radiotherapy, 35.92% (74 cases) after 4 week of radiotherapy, and 37.86% (78 cases) after 6 weeks of radiotherapy. The proportions of patients ≥60 years old, with diabetes, anxiety, depression, concurrent chemotherapy, and cancer-related fatigue in the sleep disorder group were significantly higher than those in the non-sleep disorder group (P<0.05). Age and pain VAS score of the sleep disorder group were significantly higher than those of the non-sleep disorder group (P<0.05). Logistic regression analysis showed that age ≥60 years, diabetes, anxiety, depression, pain VAS score, concurrent chemotherapy, and cancer-related fatigue were independent risk factors for sleep disorders during radiotherapy for lung cancer (P<0.05). Conclusion Lung cancer patients have a relatively high risk of sleep disorders and radiotherapy increases the incidence of sleep disorders. Advanced age, diabetes, anxiety, depression, VAS score of pain, concurrent chemotherapy, and cancer-related fatigue are main risk factors for sleep disorders. Targeted interventions addressing these factors are recommended for clinical practice.

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lung cancer / radiotherapy / sleep disorder / risk factor

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ZHANG Chao, WANG Fengjuan, DU Wen, LIU Qi, LI Xia, LIU Fengjuan. Incidence and Risk Factors of Sleep Disorders During Radiotherapy for Lung Cancer[J]. Journal of Hunan Normal University(Medical Science). 2025, 22(6): 203-207

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