Analysis of Pathogen Distribution and Drug Sensitivity of Urinary Tract Infection in Elderly Patients in A Hospital in Changsha

TAN Zhixia; WAN Bin; ZENG Zhen; YANG Min; LIU Yuanqi; CAI Xiuyi; YE Xiangli; CAO Jianhua

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Journal of Hunan Normal University(Medical Science) ›› 2025, Vol. 22 ›› Issue (5) : 185-191.

Analysis of Pathogen Distribution and Drug Sensitivity of Urinary Tract Infection in Elderly Patients in A Hospital in Changsha

TAN Zhixia^1,2, WAN Bin¹, ZENG Zhen¹, YANG Min¹, LIU Yuanqi², CAI Xiuyi², YE Xiangli², CAO Jianhua¹

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Abstract

Objective To analyze the pathogenic bacterial distribution and drug resistance of elderly patients with urinary tract infection in Changsha area were analyzed to provide evidence for infection prevention and clinical rational use of antibiotics. Methods From January 2015 to December 2022, The results of bacterial identification and drug sensitivity in urine culture of elderly inpatients aged 61 years and above with urinary tract infection in a hospital in Changsha were retrospectively analyzed. Results 1 409 strains of pathogenic bacteria were isolated and cultured from 3 187 urine samples, the detection rate was 44.21%, among which 1 129 strains of Gram-negative bacillus (80.12%), 195 strains of Gram-positive coccus (13.84%) and 85 strains of fungi (6.03%) were detected. The top 6 bacteria in detection rate were Escherichia coli (41.58%), Proteus Mirabilis (13.13%), Klebsiella pneumoniae (11.28%), Pseudomonas aeruginosa (5.75%), Enterococcus faecalis (5.54%) and Enterococcus faecium (5.32%) respectively. Bacterial distribution: Statistical analysis of the main pathogens detected according to gender distribution showed that the detection rate of Escherichia coli in elderly female patients (22.86%) was higher than that in elderly male patients (14.45%), while the detection rate of Proteus Mirabilis in elderly male patients (6.96%) was higher than that in elderly female patients (4.49%), and there was statistical significance. The stratified logistic regression analysis of the detection rate of pathogenic bacteria by age showed that the detection rate increased with age in women, and increased slightly in men over 71 years old. The number of strains detected was the highest in 81-90 years old age group. The number of strains detected was the highest in 81-90 years old age group. Drug susceptibility analysis: The resistance of Escherichia coli to quinolones and cephalosporins was 56%-71%. Proteus Mirabilis showed obvious resistance to quinolones and aminoglycosides, up to 50%-89%, but no resistance to meropenem was found. Conclusions The pathogenic bacteria of urinary tract infection in elderly patients were mainly Gram-negative bacilli. With the increase of age, the number of strains was more distributed, and the elderly women were more susceptible to Escherichia coli, while the elderly men were more susceptible to Proteus mirabilis. The main Gram-negative bacilli showed obvious resistance to quinolones, cephalosporins and amino sugars.

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elderly patients / urinary tract infection / distribution of bacteria / drug sensitivity analysis

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TAN Zhixia, WAN Bin, ZENG Zhen, YANG Min, LIU Yuanqi, CAI Xiuyi, YE Xiangli, CAO Jianhua. Analysis of Pathogen Distribution and Drug Sensitivity of Urinary Tract Infection in Elderly Patients in A Hospital in Changsha[J]. Journal of Hunan Normal University(Medical Science). 2025, 22(5): 185-191

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