Objective To investigate the effects of arteriovenous fistula (AVF) closure on cardiac structure and function, as well as changes in cardiac biomarkers, in renal transplant recipients. Methods A retrospective analysis of clinical data from 126 patients who underwent renal transplantation at the Nephrology Department of Xinjiang 474 Hospital between June 2021 and April 2024. The study included 66 patients in the AVF closure group and 60 patients in the AVF preservation group. All patients underwent baseline and follow-up ultrasonic cardiogram (UCG) imaging to assess cardiac structure and function. Serum creatinine (SCr), estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), and cardiac biomarkers N-terminal pro-B-type natriuretic peptide (NT-proBNP), cardiac troponin T (cTnT), and cardiac troponin I (cTnI) were measured. Pearson correlation and multiple linear regression analyses were performed to evaluate the associations between NT-proBNP, cTnT, cTnI, and cardiac structure and function post-AVF closure. Results Post-follow-up, in terms of cardiac structure, patients in the AVF closure group exhibited significant reductions in left ventricular (LV) mass, LV mass index, LV end-diastolic volume, LV end-systolic volume, left atrial (LA) volume, LA volume index, and right atrial (RA) area (P<0.05). For cardiac function, LV cardiac output, LV cardiac index, and pulmonary artery flow velocity were significantly reduced (P<0.05), while LV ejection fraction and blood pressure showed no significant changes (P>0.05). Cardiac biomarkers (NT-proBNP, cTnT, cTnI) were significantly reduced (P<0.05), whereas renal biomarkers (SCr, eGFR, BUN) showed no significant changes (P>0.05). Pearson correlation analysis revealed positive correlations between NT-proBNP, cTnT, cTnI, and changes in cardiac structure and function (P<0.05). Multiple linear regression showed that NT-proBNP was an independent correlate of changes in cardiac structure and function. Conclusion The reduction in NT-proBNP levels following AVF closure in renal transplant recipients is closely associated with improvements in cardiac structure and function, suggesting its potential value in the assessment of postoperative cardiac status.
Key words
arteriovenous fistula /
renal transplant /
NT-proBNP /
cardiac structure /
cardiac function
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