Objective To evaluate the clinical efficacy and safety of Tangning Tongluo tablets and Tangning Tongluo cream in patients with type 2 diabetic foot ulcer. Methods 100 patients with diabetic foot were randomly divided into 5 groups: control group (routine treatment), oral group (routine treatment+Tangning Tongluo tablet), external application group (routine treatment+Tangning Tongluo ointment), combined group (routine treatment+Tangning Tongluo tablet+Tangning Tongluo ointment) and high-dose oral group (routine treatment+Tangning Tongluo tablet). Finally, 5 cases were excluded. The outcomes of patients treated for 1 month and 3 months, the changes of serological indexes, and the ulcer outcomes with Wagner grade<4 or Wagner grade=4 were compared and observed, and the adverse reactions during the whole treatment period were recorded. Results There was no significant difference in baseline data between the groups. One month after treatment, there was no significant difference in the healing rate between the general population and patients with Wagner grade<4. Three months after treatment, there were significant differences in the healing rate between the general population and patients with Wagner grade<4, and the healing rates of oral group, external application group, combined group and high-dose oral group were significantly higher than those of the control group. Serological indicators, 3 months after treatment, the level of white blood cells in the high-dose oral group decreased significantly; Except for the control group, the neutrophil count in other groups decreased significantly, and the levels of alanine aminotransferase, aspartate aminotransferase, albumin and creatinine in each group did not change significantly before and after treatment. Safety evaluation showed that the patients did not have any adverse reactions during the whole treatment. Conclusion The combined use of Tangning Tongluo Tablet and Tangning Tongluo Cream can effectively reduce wound infection and promote wound healing. Its long-term clinical efficacy is significantly higher than that of conventional treatment, and its safety is good, which improves the clinical prognosis of patients and has high clinical application value.
Key words
Tangning Tongluo /
diabetic foot ulcer /
type 2 diabetes
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