Objective To investigate the effects and clinical relevance of Amomum yam and crucian carp soup, a traditional medicinal dietary formula, on the nutrition-inflammation-immune (NII) axis in patients with uremia characterized by spleen-kidney yang deficiency. Methods A total of 91 patients diagnosed with spleen-kidney yang deficiency and uremia with malnutrition were enrolled between July 2021 and July 2024. Using a random number table method, they were assigned to a control group (n=45) or an observation group (n=46). The control group received conventional hemodialysis combined with Jiawei Zhenwu Decoction, while the observation group was treated with Amomum-Yam-Carp Soup in addition to hemodialysis. Follow-up was conducted after three months. Clinical efficacy, Traditional Chinese Medicine syndrome scores, quality of life, inflammatory markers, and nutritional indices were assessed before and after treatment. The incidence of adverse reactions was recorded. Results The overall response rate in the observation group was significantly higher than in the control group (97.83% vs 84.44%). Compared with the control group, the observation group showed significantly lower scores for fatigue, cold extremities, shortness of breath, poor appetite, and lumbar/knee weakness after treatment. Levels of hemoglobin (Hb), albumin (ALb), transferrin (TRF), and blood urea nitrogen (BUN) were significantly increased in the observation group, while total cholesterol (TC) levels showed no significant change. Nutritional indicators, including mid-arm circumference (MAC), triceps skinfold thickness (TSF), and mid-arm muscle circumference (MAMC), were significantly improved. Immunological markers also indicated an increase in CD4+ and CD4+/CD8+ ratios and a decrease in CD8+ levels. Additionally, inflammatory markers such as interleukin-6(IL-6), high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor-alpha (TNF-α) were significantly lower post-treatment. Quality of life scores were significantly higher in the observation group. The incidence of malnutrition after treatment was significantly lower in the observation group compared to the control group (8.70% vs 51.11%). Conclusion The administration of Amomum yam and crucian carp soup alongside hemodialysis significantly improved nutritional status, reduced systemic inflammation, and enhanced immune function in patients with spleen-kidney yang deficiency uremia, ultimately contributing to better quality of life.
Key words
amomum-yam-carp soup /
traditional chinese medicinal diet /
spleen-kidney yang deficiency /
uremia /
hemodialysis
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