Objective To investigate the influence of low-temperature plasma radiofrequency ablation (TCAR) combined with collagenase injection on cervical pain and function in patients with cervical spondylotic radiculopathy (CSR). Methods The clinical data of CSR patients admitted from September 2021 to September 2023 were retrospectively analysed, and according to the treatment method of the patients, 46 cases were randomly selected from those who underwent collagenase injection treatment to be included in the control group, and 46 cases were randomly selected from those who underwent TCAR combined with collagenase injection treatment to be included in the combined group. The clinical efficacy at 12 months after treatment and pain degree [visual analogue scale (VAS)], cervical spine function (NDI), cervical spine activities, serum indicators [cyclooxygenase-2 (COX-2), neuropeptide Y (NPY), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] at different time points after treatment were compared between groups. Results After 12 months of treatment, the total effective rate of clinical efficacy in combined group was higher than that in control group. The VAS、NDI score in the two groups at 6 months and 12 months after treatment was reduced compared with that before treatment, and the score in the same group at 12 months after treatment was lower than that at 6 months after treatment, and the score at each time point after treatment was lower in combined group than that in control group. At 6 months after treatment, the cervical spine activities were increased in the two groups, and the indicators in combined group were higher compared to control group. The levels of COX-2, NPY, IL-6 and TNF-α in both groups were decreased, and the above levels were lower in combined group than those in control group. Conclusion The application of TCAR combined with collagenase injection can significantly improve the severity of cervical pain in patients with CSR, restore the cervical spine function, and help to enhance the clinical efficacy of patients.
Key words
cervical spondylotic radiculopathy /
low-temperature plasma radiofrequency ablation /
collagenase injection therapy /
cervical pain /
cervical spine function
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