Objective To systematically evaluate the clinical efficacy and safety of Qingrezhike paste combined with acarbose in the treatment of type 2 diabetes mellitus (T2DM) by retrospective case analysis, focusing on its effects on islet function, glucose metabolism level and related parameters of lipid metabolism in patients. Methods The clinical data of 88 T2DM patients treated in our hospital from February 2021 to December 2022 were retrospectively analyzed, and they were divided into Acca group (46 cases) and combined group (42 cases) according to different therapeutic drugs after standard screening. The acca group was treated with acarbose, and the combined group was treated with Qingrezhike ointment combined with acarbose. The levels of glucose metabolism [fasting blood glucose (FBG), 2 h Blood glucose (PBG), glycosylated hemoglobin (HbA1c)], islet function [fasting insulin (INS), insulin resistance index (HOMA-IR), C-peptide (CP)], lipid metabolism-related parameters [total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) LDL-C)], clinical efficacy; Pearson correlation was used to analyze the correlation between glucose metabolism and islet function and lipid metabolism. Results After treatment, the levels of FBG, PBG, and HbA1c in both groups of patients were significantly lower than before treatment, and the levels of FBG, PBG, and HbA1c in the combination group of glucose patients were lower than those in the Acao group. CP in two groups was higher than before treatment, INS and HOMA-IR were lower than before treatment, CP in combination group was higher than that in Acao group, INS and HOMA-IR were lower than that in Acao group. HDL-C in both groups was higher than before treatment, TC, TG and LDL-C were lower than before treatment, HDL-C in combination group was higher than Acca group, TC, TG and LDL-C were lower than Acca group. The total effective rate of combination group was higher than that of acca group. Pearson correlation analysis showed that FBG was positively correlated with INS, HOMA-IR, TG, LDL-C, and negatively correlated with HDL-C. PBG was positively correlated with INS, HOMA-IR, TG, LDL-C, and negatively correlated with HDL-C. HbA1c was positively correlated with HOMA-IR and TG, and negatively correlated with CP. Conclusion Qingrezhike paste combined with acarbose has good clinical effect in the treatment of T2DM, especially in improving glucose metabolism, restoring islet function and regulating lipid metabolism, which is worthy of clinical application.
Key words
qingrezhike ointment /
acarbose /
type 2 diabetes /
curative effect
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