A study on the efficacy of huachansu capsule combined with sorafenib in the treatment of patients with hepatocellular carcinoma

ZHANG Qian; ZHOU Jian; WANG Rongrong; CHEN Mao; MAO Tingyu

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Journal of Hunan Normal University(Medical Science) ›› 2025, Vol. 22 ›› Issue (2) : 6-10.

A study on the efficacy of huachansu capsule combined with sorafenib in the treatment of patients with hepatocellular carcinoma

ZHANG Qian¹, ZHOU Jian¹, WANG Rongrong¹, CHEN Mao¹, MAO Tingyu²

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Abstract

Objective To investigate the clinical efficacy and the effect on alpha-fetoprotein (AFP) and vascular endothelial growth factor (VEGF) indexes of huazhuxin capsule combined with sorafenib in the treatment of patients with primary hepatocellular carcinoma. Methods Between June 2021 and June 2024, a total of 126 patients diagnosed with primary hepatocellular carcinoma at Hunan Provincial Hospital of Integrative Medicine were enrolled and randomized into two groups using a random number table. The control group (n=63) received sorafenib therapy, while the observation group (n=63) was administered Huachansu Capsule in addition to the sorafenib treatment received by the control group. Comparison of the two groups after 3 months of treatment in both groups. Results The observation group exhibited a notably higher therapeutic efficacy compared to the control group. Subsequent to therapy, the concentrations of serum albumin (ALB), total bilirubin (TBIL), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were markedly decreased in the observation group when contrasted with the control group. Additionally, the levels of vascular endothelial growth factor (VEGF), alpha-fetoprotein (AFP), and tumor-specific growth factor (TSCF) in the observation group were also significantly reduced compared to the control group. Post-treatment, enhancements were observed across all domains of the European Organisation for Research and Treatment of Cancer's Core Quality of Life Questionnaire-30(EORTC QLQ-C30) in both patient cohorts, albeit with the observation group demonstrating statistically significant superior improvements compared to the control group. There was no statistically significant difference in the incidence of adverse reactions between the two groups. Conclusion To treat patients with primary hepatocellular carcinoma, huazhuxin capsule and sorafenib have better efficacy, which helps to improve patients' liver function indexes, reduce the level of tumor markers, and improve patients' quality of life, without increasing the risk of adverse reactions.

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toadstool capsules / sorafenib / primary hepatocellular carcinoma / clinical efficacy

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ZHANG Qian, ZHOU Jian, WANG Rongrong, CHEN Mao, MAO Tingyu. A study on the efficacy of huachansu capsule combined with sorafenib in the treatment of patients with hepatocellular carcinoma[J]. Journal of Hunan Normal University(Medical Science). 2025, 22(2): 6-10

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