Correlation between quantitative electroencephalogram parameters and serum NO level in patients with schizophrenia

ZHANG Lei; CHENG Fei; YU Wanqing

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Journal of Hunan Normal University(Medical Science) ›› 2025, Vol. 22 ›› Issue (2) : 1-5.

Clinical Medicine

Correlation between quantitative electroencephalogram parameters and serum NO level in patients with schizophrenia

ZHANG Lei, CHENG Fei, YU Wanqing

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Abstract

Objective To explore the correlation between quantitative electroencephalogram (qEEG) parameters and serum nitric oxide (NO) level in patients with schizophrenia (SZ). Methods From January 2023 to December 2023, 90 patients with SZ were selected as the study group. In the same period, 90 healthy people who came to the hospital for physical examination served as the control group. The study group was divided into group A (n=45, high level) and group B (n=45, low level) according to the median serum NO level. qEEG parameters and serum NO levels were compared between SZ patients and healthy people. Compared the qEEG parameters of SZ patients with different serum NO levels. Spearman correlation analysis of the relationship between qEEG parameters and serum NO level in SZ patients. Results The absolute power of θ, δ and β waves, θ/α power ratio (TAR) and serum NO level in the study group were higher, while the α wave power was lower. The absolute power and TAR of θ, δ and β waves in group A were higher, while the power of α wave was lower. The absolute power of θ, δ, β waves and TAR were positively correlated with the serum NO level of SZ patients. The absolute power of α wave was negatively correlated with serum NO level in SZ patients. Conclusion There is a certain correlation between qEEG parameters and serum NO level in SZ patients, and the change of serum NO level may be related to SZ nerve injury.

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schizophrenia / quantitative electroencephalogram / nitric oxide / correlation

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ZHANG Lei, CHENG Fei, YU Wanqing. Correlation between quantitative electroencephalogram parameters and serum NO level in patients with schizophrenia[J]. Journal of Hunan Normal University(Medical Science). 2025, 22(2): 1-5

References

[1] 章丽, 胡丽珍, 方云. 积极心理学理论下精神康复护理模式对精神分裂症患者认知及康复水平的影响[J]. 中国医药导报, 2024, 21(13): 158-161.
[2] HARVEY PD, ISNER EC.Cognition, social cognition, and functional capacity in early-onset schizophrenia[J]. Child Adolesc Psychiatr Clin N Am, 2020, 29(1): 171-182.
[3] 杨凡, 徐沛琳, 黄悦勤, 等. 不同首发年龄精神分裂症患者临床特征及影响因素[J]. 中国心理卫生杂志, 2024, 38(1): 16-24.
[4] FONSECA E, QUINTANA M, SEIJO-RAPOSO I, et al.Interictal brain activity changes in temporal lobe epilepsy: a quantitative electroencephalogram analysis[J]. Acta Neurol Scand, 2022, 145(2): 239-248.
[5] SCHULTHEIS C, ROSENBROCK H, MACK SR, et al.Quantitative electroencephalography parameters as neurophysiological biomarkers of schizophrenia-related deficits: a phase II substudy of patients treated with iclepertin (BI 425809)[J]. Transl Psychiatry, 2022, 12(1): 329.
[6] STANCA S, ROSSETTI M, BOKULIC PANICHI L, et al.The cellular dysfunction of the brain-blood barrier from endothelial cells to astrocytes: the pathway towards neurotransmitter impairment in schizophrenia[J]. Int J Mol Sci, 2024, 25(2): 1250.
[7] BIANCIARDI B, MASTEK H, FRANKA M, et al.Effects of N-methyl-d-aspartate receptor antagonists on gamma-band activity during auditory stimulation compared with electro/magneto-encephalographic data in schizophrenia and early-stage psychosis: a systematic review and perspective[J]. Schizophr Bull, 2024, 50(5): 1104-1116.
[8] 裴桐忻, 张克忠, 鲁严. 一氧化氮在神经精神疾病中作用的研究进展[J]. 南京医科大学学报 (自然科学版), 2024, 44(8): 1155-1164.
[9] 杨曼, 杨海东, 闫琳雅, 等. 慢性精神分裂症男性患者血浆一氧化氮及其合成酶活性的临床研究[J]. 神经疾病与精神卫生, 2022, 22(1): 23-28.
[10] 戴云飞, 肖泽萍. 中国精神障碍分类与诊断标准第3版与国际疾病分类第10版的比较[J]. 临床精神医学杂志, 2013, 23(6): 426-427.
[11] 王安珍, 张许来, 严凡凡, 等. 精神分裂症患者不同阶段血清IL-1β、IL-16水平与阴性症状相关性研究[J]. 安徽医科大学学报, 2024, 59(4): 703-708.
[12] PASQUINI S, CONTRI C, MERIGHI S, et al.Adenosine receptors in neuropsychiatric disorders: fine regulators of neurotransmission and potential therapeutic targets[J]. Int J Mol Sci, 2022, 23(3): 1219.
[13] 甘景梨, 段惠峰, 杨富增, 等. 阴性与阳性症状为主的精神分裂症患者脑部质子波谱比较研究[J]. 中华行为医学与脑科学杂志, 2011, 20(1): 37-39.
[14] BYEON J, MOON JY, JE SR, et al.Quantitative electroencephalographic biomarker of pharmacological treatment response in patients with anxiety disorder: a retrospective study[J]. Sci Rep, 2023, 13(1): 3802.
[15] MCVOY M, CHUMACHENKO S, BRIGGS F, et al.A predictive biomarker model using quantitative electroencephalography in adolescent major depressive disorder[J]. J Child Adolesc Psychopharmacol, 2022, 32(9): 460-466.
[16] KOPAŃSKA M, OCHOJSKA D, DEJNOWICZ-VELITCHKOV A, et al. Quantitative electroencephalography (QEEG) as an innovative diagnostic tool in mental disorders[J]. Int J Environ Res Public Health, 2022, 19(4): 2465.
[17] YANG S, KIM JW.Electrophysiological markers predicting antipsychotic treatment response in patients with schizophrenia: a retrospective study[J]. Neuropsychiatr Dis Treat, 2024, 20: 1387-1394.
[18] 王津鑫, 陈衍华, 王娟. 精神分裂症伴抑郁症患者血清iNOS、TBARS水平及其与疾病严重程度的相关性研究[J]. 精神医学杂志, 2023, 36(3): 246-250.
[19] PENG S, LIANG C, DENG S, et al.Study on the clinical correlation between the expression of serum TNF-α and iNOS as well as cognitive impairment and disease burden in patients with schizophrenia[J]. Pak J Med Sci, 2022, 38(7): 1838-1843.
[20] OLTHOF BMJ, GARTSIDE SE, REES A.Puncta of neuronal nitric oxide synthase (nNOS) mediate NMDA receptor signaling in the auditory midbrain[J]. J Neurosci, 2019, 39(5): 876-887.
[21] ŚMIERCIAK N, KRZYŚCIAK W, SZWAJCA M, et al. Improvement in clinical symptoms in patients with the first episode of psychosis is associated with a decrease in systemic nitric oxide availability. a pilot study. Związek poprawy objawów klinicznych u pacjentów z pierwszym epizodem psychozy i jej związek ze spadkiem ogólnoustrojowej dostępności tlenku azotu. Badanie pilotażowe[J]. Psychiatr Pol, 2021, 55(3): 541-554.
[22] DJORDJEVIĆ VV, LAZAREVIĆ D, ĆOSIĆ V, et al.Diagnostic accuracy of brain-derived neurotrophic factor and nitric oxide in patients with schizophrenia: a pilot study[J]. J Med Biochem, 2016, 35(1): 7-16.
[23] 刘学勤, 曹长杰, 王涛, 等. 首发未用药精神分裂症患者血清氧化应激水平与认知功能的关系[J]. 中南医学科学杂志, 2023, 51(6): 883-885.