The evaluation value of combined detection of uric acid and immune inflammatory index for the degree and prognosis of carotid artery lesions in stroke patients receiving CAS

LIU Huan; FAN Pengfei

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Journal of Hunan Normal University(Medical Science) ›› 2025, Vol. 22 ›› Issue (1) : 99-104.

The evaluation value of combined detection of uric acid and immune inflammatory index for the degree and prognosis of carotid artery lesions in stroke patients receiving CAS

LIU Huan¹, FAN Pengfei^1,2

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Abstract

Objective To explore the relationship between uric acid combined with systemic immune inflammatory index (SII) and the severity and prognosis of carotid artery lesions in high-risk patients with stroke. Methods This single-center retrospective study analyzed 129 patients who received carotid artery stenting (CAS) in our hospital from January 2018 to January 2019. SII was defined as peripheral platelet count × neutrophil/lymphocyte count. The main end point of this study was the incidence of major adverse cerebrovascular events (MACCE) in the long term (from discharge to 5-year follow-up), including all-cause mortality, stroke and myocardial infarction. Secondary end points were the incidence of stroke and all-cause death during hospitalization and long-term follow-up. Results Patients were divided into three groups (Q1, Q2 and Q3) according to the trivalence of SII, and there were significant differences in plaque area, platelet, neutrophil, leukocyte, uric acid and SII levels among the three groups (P<0.05). The incidence of stroke and MACCE in Q1 to Q3 groups increased gradually, and higher SII level was correlated with higher incidence (all P<0.01). Kaplan-Meier curve showed that with the increase of SII, the cumulative incidence of MACCE increased gradually [Log Rank (Mantel-Cox)=13.128, P=0.001]. Cox regression analysis showed that SII [hazard ratio (HR)=1.004, 95%CI: 1.002-1.006], age (HR=1.107, 95%CI: 1.018-1.203), uric acid (HR=1.004, 95%CI: 1.001-1.007). Pearson analysis showed that SII was positively correlated with uric acid level (r=0.226, P=0.011) and plaque size (r=0.274, P=0.003). ROC analysis showed that the AUC of SII was 0.741 (95%CI: 0.616-0.866; P<0.001), and the AUC of uric acid was 0.723 (95%CI: 0.604-0.843; P<0.001), the AUC of the combination of them increased significantly (0.910, 95%CI: 0.843-0.977; P<0.001). Conclusions Increased levels of SII and uric acid are independent predictors of long-term MACCE in high-risk patients with CAS stroke, and their combined application has high application value in identifying long-term MACCE.

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uric acid / systemic immune inflammatory index / high-risk patients with stroke / carotid stent implantation / major adverse cardiovascular eventsts

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LIU Huan, FAN Pengfei. The evaluation value of combined detection of uric acid and immune inflammatory index for the degree and prognosis of carotid artery lesions in stroke patients receiving CAS[J]. Journal of Hunan Normal University(Medical Science). 2025, 22(1): 99-104

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