Clinical Value of Ultrasound-Guided Fine-Needle Aspiration Cytology Combined with BRAFV600E Gene Detection in Early Diagnosis of Thyroid Cancer

WU Liu; ZHAO Ping; ZHANG Chaoyang

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Journal of Hunan Normal University(Medical Science) ›› 2024, Vol. 21 ›› Issue (6) : 89-92.

Clinical Value of Ultrasound-Guided Fine-Needle Aspiration Cytology Combined with BRAF^V600E Gene Detection in Early Diagnosis of Thyroid Cancer

WU Liu, ZHAO Ping, ZHANG Chaoyang

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Abstract

Objective To analyze the clinical value of ultrasound-guided fine needle aspiration (FNA) cytology combined with BRAF^V600E genetic testing in the early diagnosis of thyroid cancer (TC). Methods A total of 150 patients with suspected TC admitted to our hospital from January 2021 to December 2023 were selected as study subjects. All patients underwent ultrasound-guided FNA cytology and BRAF^V600E gene detection. With postoperative pathological diagnosis as the gold standard, the positive detection rates and diagnostic efficacy of ultrasound-guided FNA cytology, BRAF^V600E gene detection alone, and their combination were compared. Receiver operating characteristic (ROC) curves were plotted, and the area under the curve (AUC) was used to analyze the diagnostic value of ultrasound-guided FNA cytology, BRAF^V600E gene detection alone, and their combination. Results Postoperative pathology showed that 92 patients (61.33%) were diagnosed with TC. Ultrasound-guided FNA cytology showed 96 positive cases (64.00%) and 54 negative cases (36.00%). BRAF^V600E gene detection showed 78 positive cases (52.00%) and 72 negative cases (48.00%). When ultrasound-guided FNA cytology was combined with BRAF^V600E gene detection, 99 cases (66.00%) were positive and 51 cases (34.00%) were negative. The diagnostic efficacy of ultrasound-guided FNA cytology combined with BRAF^V600E gene detection was higher than that of ultrasound-guided FNA cytology or BRAF^V600E gene detection alone (P<0.05). The AUC of ultrasound-guided FNA cytology combined with BRAF^V600E gene detection was significantly greater than that of ultrasound-guided FNA cytology or BRAF^V600E gene detection alone. Conclusion Ultrasound-guided FNA cytology combined with BRAF^V600E gene detection has important value in the diagnosis of TC patients, can effectively improve the accuracy of early diagnosis, and has good clinical efficacy.

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BRAF^V600E gene detection / thyroid cancer / ultrasound guidance / fine-needle aspiration / cytology examination

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WU Liu, ZHAO Ping, ZHANG Chaoyang. Clinical Value of Ultrasound-Guided Fine-Needle Aspiration Cytology Combined with BRAF^V600E Gene Detection in Early Diagnosis of Thyroid Cancer[J]. Journal of Hunan Normal University(Medical Science). 2024, 21(6): 89-92

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