The clinical effect of lamotrigine combined with high-dose diazepam in the treatment of benign epilepsy in children with central temporal spikes and epileptic electrical persistence during sleep

LU Lin; QU Rui; DAI Yuanyuan

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Journal of Hunan Normal University(Medical Science) ›› 2024, Vol. 21 ›› Issue (4) : 93-96.

The clinical effect of lamotrigine combined with high-dose diazepam in the treatment of benign epilepsy in children with central temporal spikes and epileptic electrical persistence during sleep

LU Lin, QU Rui, DAI Yuanyuan

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Abstract

Objective To evaluate the clinical efficacy of lamotrigine combined with high-dose diazepam in the treatment of benign epilepsy in children with central temporal spike wave (BECT) and status epilepticus during sleep (ESES) . Methods Clinical data of 80 children with BECT combined with ESES admitted to Xuzhou Medical University Affiliated Hospital from January 2019 to February 2023 were selected. They were randomly divided into a control group (treated with lamotrigine) and an observation group (treated with lamotrigine combined with high-dose diazepam) using a random number table method, with 40 cases in each group. Both groups were treated for 3 months. Compare the clinical efficacy, frequency and duration of seizures, discharge index, EEG activity, PIQ, VIQ, FIQ scores, serum biomarker levels, and incidence of adverse reactions between two groups. Results The total effective rate of the observation group was higher than that of the control group; The frequency of epileptic seizures in the observation group was lower than that in the control group, and the duration was shorter than that in the control group. The number of epileptiform discharges and the number of involved leads were both lower than those in the control group, and the difference was statistically significant; The scores of VIQ, PIQ, and FIQ, as well as the EEG, improved in both groups compared to before treatment. The PIQ, PIQ, FIQ, and serum biomarker levels in the observation group were higher than those in the control group; The difference was statistically significant; There was no statistically significant difference in the incidence of adverse reactions between the two groups. Conclusion The combination of lamotrigine and high-dose diazepam can improve the efficacy and safety of BECT combined with ESES in children.

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benign temporal epilepsy in childhood / persistent spike discharge during sleep / lamotrigine / high dose diazepam

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LU Lin, QU Rui, DAI Yuanyuan. The clinical effect of lamotrigine combined with high-dose diazepam in the treatment of benign epilepsy in children with central temporal spikes and epileptic electrical persistence during sleep[J]. Journal of Hunan Normal University(Medical Science). 2024, 21(4): 93-96

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