Relationship between CYP2C19 gene polymorphism and curative effect of butyphthalide in acute cerebral infarction

MA Qingchuan; MU Ni; WU Xi; YAN Liangliang

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Journal of Hunan Normal University(Medical Science) ›› 2024, Vol. 21 ›› Issue (3) : 96-99.

Clinical Medicine

Relationship between CYP2C19 gene polymorphism and curative effect of butyphthalide in acute cerebral infarction

MA Qingchuan¹, MU Ni², WU Xi¹, YAN Liangliang¹

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Abstract

Objective To explore the relationship between gene polymorphism of cytochrome P450 2C19(CYP2C19) and curative effect of butyphthalide in acute cerebral infarction (ACI). Methods A total of 216 patients with ACI were enrolled as the research objects between February and December 2023. All patients were treated with butyphthalide, and blood concentration of butyphthalide was detected after 7d of treatment. According to scores of National Institutes of Health Stroke Scale (NHISS), patients were divided into effective group (NHISS score decreased by ≥45%, n=112) and ineffective group (NHISS score decreased by <45%, n=104). CYP2C19 gene polymorphisms were detected by high-throughput genotyping technique. The effects of CYP2C19 gene polymorphisms on curative effect of butyphthalide in ACI patients were analyzed by multivariate Logistic regression analysis. Results After 7d of treatment, scores of NIHSS and mRS were decreased, and ADL score was increased. After 7d of treatment, blood concentration of fast-metabolism butyphthalide was higher than that in intermediate-metabolism and slow-metabolism butyphthalide. The frequencies of GG gene at CYP2C19*2 and CYP2C19*3 loci in effective group were higher than those in ineffective group. Binary Logistic regression analysis showed that atrial fibrillation (OR=2.366, P=0.019), NIHSS score before treatment (OR=2.358, P=0.016), CYP2C19*2(OR=4.423, P<0.001) and CYP2C19*3(OR=2.316, P=0.028) were all independent risk factors affecting the curative effect of butyphthalide in ACI patients. Conclusion The polymorphisms of CYP2C19 gene are related to the curative effect of butyphthalide in ACI, and curative effect is worse in patients with A allele.

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acute cerebral infarction / cytochrome P450 2C19 / gene polymorphism / butyphthalide

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MA Qingchuan, MU Ni, WU Xi, YAN Liangliang. Relationship between CYP2C19 gene polymorphism and curative effect of butyphthalide in acute cerebral infarction[J]. Journal of Hunan Normal University(Medical Science). 2024, 21(3): 96-99

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