Anesthetic effects of propofol and etomidate separately combined with remifentanil target controlled infusion in painless rigid bronchoscopy

LI Na; YANG Mingyuan; CHENG Qinghao

PDF(2313 KB)

Journal of Hunan Normal University(Medical Science) ›› 2024, Vol. 21 ›› Issue (2) : 86-88.

Anesthetic effects of propofol and etomidate separately combined with remifentanil target controlled infusion in painless rigid bronchoscopy

LI Na, YANG Mingyuan, CHENG Qinghao

Author information +

History +

Abstract

Objective To investigate the anesthetic effects of propofol and etomidate separately combined with remifentanil target controlled infusion (TCI) in painless rigid bronchoscopy. Methods A total of 60 patients who underwent painless rigid bronchoscopy were divided into propofol (P) group and etomidate (E) group with 30 patients in each group. P group received propofol combined with remifentanil TCI while E group received etomidate combined with remifentanil TCI. The time to fall asleep, wake-up time, vital signs before anesthesia (T₀), immediately after the bronchoscope reaching the glottis (T₁), immediately after the end of examination (T₂) and at 10 min after the end of examination (T₃) were compared between the two groups. Stress status was recorded, and the occurrence of adverse reactions was analyzed. Results There was no significant difference in the time to fall asleep or wake-up time between the two groups. Compared with T₀, there were increases in mean arterial pressure (MAP), pulse oxygen saturation (SpO₂) and heart rate (HR) in both groups at T₁ and T₂, and decreases at T₃. From T₁ to T₃, MAP, SpO₂ and HR in E group were higher than those in P group. The incidence rates of injection pain and hypotension in E group were lower than those in P group. The incidence rates of nausea and vomiting and bradycardia in the two groups were close. Conclusion Applying etomidate combined with remifentanil TCI in painless rigid bronchoscopy can achieve better anesthetic effects. It has obvious advantages in maintaining stable vital signs, and the incidence rates of injection pain and hypotension are lower.

Key words

painless rigid bronchoscopy / propofol / etomidate / remifentanil / target controlled infusion / anesthetic effect

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

LI Na, YANG Mingyuan, CHENG Qinghao. Anesthetic effects of propofol and etomidate separately combined with remifentanil target controlled infusion in painless rigid bronchoscopy[J]. Journal of Hunan Normal University(Medical Science). 2024, 21(2): 86-88

References

[1] 陈玢,马正良,刘涛,等.艾司氯胺酮联合丙泊酚用于无痛支气管镜检查麻醉的临床应用[J].国际麻醉学与复苏杂志,2021,42(12):1277-1280.
[2] SHIN HJ,WOO NAM S,KIM H,et al.Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia:A Randomized Controlled Trial[J].Anesthesiology,2023,138(2):164-171.
[3] 蒋向群,梁民勇,于素云,等.右美托咪啶联合丙泊酚与芬太尼用于无痛纤维支气管镜的临床价值[J].中国社区医师,2019,35(33):11-12.
[4] 李淑蓉,林春兰,吴清华,等.靶控输注联合声门上喷射通气在老年无痛纤维支气管镜检查中的应用[J].临床肺科杂志,2019,24(9):1586-1591.
[5] KHAN A,BASHOUR SI,CASAL RF.Preventing atelectasis during bronchoscopy under general anesthesia[J].J Thorac Dis,2023,15(6):3443-3452.
[6] 张蕾,寇立华,高学.丙泊酚对行无痛气管镜检查患者的阵痛效果评估[J].解放军预防医学杂志,2019,37(5):117-118.
[7] 朱伟伟,钱望月,唐然,等.脑电双频指数监测下盐酸右美托咪定预注在小儿无痛支气管镜诊疗中的价值研究[J].中国医学装备,2022,19(9):90-93.
[8] 刘慧敏,付卫东,罗柳,等.亚麻醉剂量艾司氯胺酮联合应用丙泊酚对老年无痛肠镜检查患者苏醒质量及促炎因子的影响[J].湖南师范大学学报(医学版),2023,20(5):111-116.
[9] 郭丰,于桂杰,王兰,等.依托咪酯联合穴位刺激用于老年患者无痛结肠镜检查的临床观察[J].世界中西医结合杂志,2022,17(3):589-591,596.
[10] 郭春燕,解雅英,于建设,等.靶控输注异丙酚与瑞芬太尼在冠心病病人无痛胃镜检查中最佳配伍研究[J].内蒙古医科大学学报,2020,42(2):148-152.
[11] 顾程翔. 瑞芬太尼靶控输注复合丙泊酚在老年无痛胃镜检查中的麻醉效果[J].中国药物与临床,2019,19(17):2961-2963.
[12] 杨许丽,吴宇,倪坤,等.丙泊酚靶控输注麻醉在机器人辅助前列腺癌根治手术中应用效果观察[J].临床军医杂志,2021,49(3):294-295.
[13] 高鹏,李林.瑞芬太尼靶控输注联合经皮穴位电刺激在输尿管镜碎石术中的应用[J].实用药物与临床,2019,22(11):1148-1152.
[14] 王宁,曹亚楠,朱泽飞,等.盐酸右美托咪定联合依托咪酯麻醉对宫腔镜手术患者血流动力学,炎症反应及氧化应激水平的影响[J].现代生物医学进展,2021,21(19):3694-3699.
[15] 冯松,杨刚,田春林,等.依托咪酯靶控输注联合纳布啡麻醉对子宫肌瘤剔除术患者血流动力学及术后感染的影响[J].中华医院感染学杂志,2020,30(17):2687-2690.
[16] 陈晓芳,张国艳,徐志新.依托咪酯乳剂联合丙泊酚对全麻诱导时血流动力学及红细胞免疫黏附功能功能的影响[J].医学临床研究,2019,36(2),346-347+348.
[17] 高雅,张林忠,张金渊,等.依托咪酯持续输注对老年腰椎手术患者氧化应激及术后恢复质量的影响[J].实用药物与临床,2023,26(3):206-210.
[18] 田浩,张艺,熊永红,等.依托咪酯和丙泊酚用于无痛结肠镜时麻醉效果的Meta分析[J].临床麻醉学杂志,2021,37(11):1182-1189.
[19] 王景华,王璇,王小鹏,等.无痛胃肠镜检查中应用依托咪酯-丙泊酚混合液的麻醉效果[J].武警医学,2020,31(8):688-691+694.
[20] 高玉蓓,李寿春,赵瑞珍,等.依托咪酯联合环泊酚全身麻醉对手术患者血流动力学和应激反应的影响[J].中国医药导刊,2023,25(3):297-302.