Objective To investigate the relationship between the expression of hypoxia-inducible factor 1α (HIF-1α) /vascular endothelial growth factor (VEGF) and the condition and prognosis of basal ganglia hemorrhage. Methods A total of 106 patients with basal ganglia hemorrhage from January 2019 to January 2022 were selected as the research subjects. The concentrations of serum HIF-1α and VEGF were measured by sandwich enzyme-linked immunosorbent assay with double antibodies. The associations between serum HIF-1α and VEGF concentrations and early neurological deterioration and poor prognosis 3 months after injury were analyzed by multivariate logistic regression, and the predictive power of the variables was assessed by receiver operating characteristic curve. Results The serum HIF-1α and VEGF concentrations at admission were significantly positively correlated with the admission NIHSS score (r=0.6267, 0.8495, both P<0.001). With the increase of baseline hematoma size, the serum HIF-1α and VEGF concentrations were significantly increased after acute ICH (r=0.5352, 0.6418, both P<0.001). Serum HIF-1α concentration (OR=4.054, 95%CI: 1.368-12.009; P=0.012) and serum VEGF concentration (OR=1.821, 95%CI: 1.119-2.965; P=0.016) were independent of END after acute ICH predictor. Serum HIF-1α concentration (OR=4.721, 95%CI: 1.662-13.407; P=0.014) and serum VEGF concentration (OR=2.198, 95%CI: 1.204-4.013, P=0.010) were associated with worse prognosis after acute ICH independent predictors. Serum HIF-1α concentration predicted early neurological deterioration (AUC=0.746, 95%CI: 0.6572-0.8178, P<0.001) and 3-month prognosis (AUC=0.7744, 95%CI: 0.7072-0.8416; P<0.001) was better than the serum VEGF concentrations (AUC=0.6882, 95%CI: 0.6113-0.7650; P<0.001 and AUC=0.7025, 95%CI: 0.6270-0.7780; P<0.001). Conclusion Serum HIF-1α and VEGF concentrations are independently associated with END and poor prognosis 3 months after ICH. In addition, the prognostic value of serum HIF-1α concentration is better than that of serum VEGF.
Key words
hypoxia-inducible factor 1α /
vascular endothelial growth factor /
basal ganglia hemorrhage /
condition /
prognosis
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