Correlation analysis of risk factors for white matter hyperintensities in cerebral small vessel disease

SU Qiyan; HUANG Biao; HU Aili; PAN Hong; HU Chongyu

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Journal of Hunan Normal University(Medical Science) ›› 2024, Vol. 21 ›› Issue (1) : 66-71.

Clinical Medicine

Correlation analysis of risk factors for white matter hyperintensities in cerebral small vessel disease

SU Qiyan¹, HUANG Biao¹, HU Aili², PAN Hong¹, HU Chongyu¹

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Abstract

Objective To evaluate the risk factors of white matter hyperintensities (WMHs) in Cerebral small vessel disease (CSVD) , and to further establish an early prediction model. Method A total of 233 patients hospitalized in Hunan Provincial People's Hospital were selected for retrospective analysis. According to the T2 sequence of head magnetic resonance plain scan to identify WMHs, they were divided into the observation group of 187 cases with WMHs and the control group of 46 cases without WMHs. The general data and related biochemical indicators of the two groups of patients in the training set were compared between the two groups, and the difference factors were analyzed by multivariate Logistic regression analysis. The receiver operating characteristic (ROC) curve was drawn for single and multiple independent risk factors, and a nomogram was constructed to establish a prediction model, and the predictive efficacy of the model was evaluated. Results There were significant differences in age, hypertension, coronary heart disease, monocyte count, blood urea nitrogen (BUN) , serum creatinine (SCr) , and glomerular filtration rate (eGFR) between the two groups of patients in the training set (P<0.05) . Multivariate regression analysis of 7 indicators showed that hypertension and SCr level were independent risk factors for WMHs. The area under the ROC curve of hypertension, SCr and the two indexes combined to predict WMHs was 0.655, 0.680 and 0.762, respectively. By constructing a nomogram for hypertension and SCr, the efficacy of the prediction model and the ROC curve of WMHs in the hypertension and SCr diagnostic validation set alone was evaluated, and the curve area was 0.763, 0.708, and 0.649, respectively. Conclusions Hypertension and SCr are independent risk factors for WMHs, and have predictive value for WMHs. The combination of hypertension and SCr is better than single index in predicting the risk of WMHs, which has guiding value for the early diagnosis of WMHs.

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white matter hyperintensity / risk factors / serum creatinine / monocyte

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SU Qiyan, HUANG Biao, HU Aili, PAN Hong, HU Chongyu. Correlation analysis of risk factors for white matter hyperintensities in cerebral small vessel disease[J]. Journal of Hunan Normal University(Medical Science). 2024, 21(1): 66-71

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