The expression and clinical significance of HOXC8 in colon cancer

WU Jichu; JIANG Xiaoye; SHEN Sizhe

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Journal of Hunan Normal University(Medical Science) ›› 2023, Vol. 20 ›› Issue (6) : 97-104.

Clinical Medicine

The expression and clinical significance of HOXC8 in colon cancer

WU Jichu, JIANG Xiaoye, SHEN Sizhe

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Abstract

Objective To investigate the expression and clinical significance of Homeobox C8 (HOXC8) in colon cancer (CC) . Methods The Cancer Genome Atlas (TCGA) database and GEO database were used to analyze HOXC8 mRNA expression in CC tissues. A total of 100 patients with CC tissue specimens and clinicopathological data were collected from Chongqing Medical University First Affiliated Hospital, and HOXC8 protein was detected by immunohistochemistry. Moreover, the association between HOXC8 expression and clinicopathological characteristics was analyzed. Univariate and multivariate Cox regression models and Kaplan-Meier were used to evaluate the prognostic value of HOXC8 in CC. The GEPIA database was used to evaluate the correlation between HOXC8 and immune cell biomarkers. Results Multi databases analysis and detection of patient tissue samples showed that the mRNA and protein expression level of HOXC8 is increased in cancer tissue (P<0.05, P<0.001) . In addition, the high expression of HOXC8 is related to poor overall survival rate (In TCGA data set, P<0.001; In GEO GSE39582 data set, P=0.008) . Cox regression analysis suggests that HOXC8 is an independent risk factor affecting the prognosis of patients with CC (In TCGA data set, P=0.002; In GEO GSE39582 data set, P= 0.039) . We also studied the potential role of HOXC8 in tumor-immune interactions, and found that HOXC8 may be significantly associated with multiple immune cells in colon cancer (P< 0.001) . Conclusion Our study showed that the expression of HOXC8 is up-regulated in CC, and revealed the prognostic potential of HOXC8 in CC and its potential as an immune-related therapeutic target for CC.

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colon cancer / HOXC8 / prognosis / immunotherapy

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WU Jichu, JIANG Xiaoye, SHEN Sizhe. The expression and clinical significance of HOXC8 in colon cancer[J]. Journal of Hunan Normal University(Medical Science). 2023, 20(6): 97-104

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