Association study between Metabolic Insulin Resistance Score and New-Onset Stroke in middle-aged and elderly Chinese population

SHA Ou; YU Yang

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Journal of Hunan Normal University(Medical Science) ›› 2023, Vol. 20 ›› Issue (5) : 70-74.

Association study between Metabolic Insulin Resistance Score and New-Onset Stroke in middle-aged and elderly Chinese population

SHA Ou, YU Yang

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Abstract

Objective Stroke is a major cause of cardiovascular mortality and may have a correlative relationship with insulin resistance. To investigate the relationship between the metabolic score for insulin resistance (METS-IR) and new-onset stroke in middle-aged and elderly people based on a large cohort study. Methods Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2018. Regression models were developed to explore the association between METS-IR and new-onset stroke, while restricted cubic spline models were used to examine possible nonlinear associations and subgroup analyses were used to explore possible potential moderating variables. Results A total of 6706 study subjects were included in the study, including 381 with new-onset stroke. The regression model results found a 67.3% increase in the risk of new-onset stroke for each quartile increase in the METS-IR (OR=1.673, 95% CI: 1.440-1.944). A linear relationship between the METS-IR and the prevalence of new-onset stroke was shown using restricted three-sample regression analysis, and stratified analysis revealed that the relationship between METS-IR and new-onset stroke was consistent across subgroups. Conclusion The METS-IR is strongly associated with the prevalence of new-onset stroke, and people with high METS-IR need to be more alert to the risk of stroke.

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METS-IR / stroke / association study / CHARLS

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SHA Ou, YU Yang. Association study between Metabolic Insulin Resistance Score and New-Onset Stroke in middle-aged and elderly Chinese population[J]. Journal of Hunan Normal University(Medical Science). 2023, 20(5): 70-74

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